Atomistry » Zinc » PDB 4fkd-4fvo » 4fvn
Atomistry »
  Zinc »
    PDB 4fkd-4fvo »
      4fvn »

Zinc in PDB 4fvn: Carbonic Anhydrase II in Complex with N-(Tetrahydropyrimidin-2(1H)- Ylidene)Sulfuric Diamide

Enzymatic activity of Carbonic Anhydrase II in Complex with N-(Tetrahydropyrimidin-2(1H)- Ylidene)Sulfuric Diamide

All present enzymatic activity of Carbonic Anhydrase II in Complex with N-(Tetrahydropyrimidin-2(1H)- Ylidene)Sulfuric Diamide:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase II in Complex with N-(Tetrahydropyrimidin-2(1H)- Ylidene)Sulfuric Diamide, PDB code: 4fvn was solved by A.Di Pizio, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 1.05
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.197, 41.420, 72.086, 90.00, 104.22, 90.00
R / Rfree (%) 13.9 / 16.5

Other elements in 4fvn:

The structure of Carbonic Anhydrase II in Complex with N-(Tetrahydropyrimidin-2(1H)- Ylidene)Sulfuric Diamide also contains other interesting chemical elements:

Mercury (Hg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Carbonic Anhydrase II in Complex with N-(Tetrahydropyrimidin-2(1H)- Ylidene)Sulfuric Diamide (pdb code 4fvn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase II in Complex with N-(Tetrahydropyrimidin-2(1H)- Ylidene)Sulfuric Diamide, PDB code: 4fvn:

Zinc binding site 1 out of 1 in 4fvn

Go back to Zinc Binding Sites List in 4fvn
Zinc binding site 1 out of 1 in the Carbonic Anhydrase II in Complex with N-(Tetrahydropyrimidin-2(1H)- Ylidene)Sulfuric Diamide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Carbonic Anhydrase II in Complex with N-(Tetrahydropyrimidin-2(1H)- Ylidene)Sulfuric Diamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn302

b:5.5
occ:1.00
 N9 A:0VW303 1.9 3.8 0.6
NE2 A:HIS94 2.0 5.3 1.0
NE2 A:HIS96 2.0 5.7 1.0
ND1 A:HIS119 2.0 5.4 1.0
CE1 A:HIS119 2.9 4.7 1.0
CD2 A:HIS94 3.0 5.7 1.0
CD2 A:HIS96 3.0 5.1 1.0
CE1 A:HIS94 3.0 5.5 1.0
CE1 A:HIS96 3.0 6.6 1.0
S8 A:0VW303 3.1 8.3 0.6
CG A:HIS119 3.1 4.9 1.0
O10 A:0VW303 3.2 7.9 0.6
CB A:HIS119 3.6 5.3 1.0
O A:HOH693 3.8 17.1 1.0
OG1 A:THR199 3.9 6.2 1.0
O11 A:0VW303 4.0 10.5 0.6
OE1 A:GLU106 4.0 5.8 1.0
NE2 A:HIS119 4.1 5.1 1.0
CG A:HIS94 4.1 5.1 1.0
ND1 A:HIS96 4.2 6.7 1.0
ND1 A:HIS94 4.2 6.0 1.0
CG A:HIS96 4.2 5.3 1.0
CD2 A:HIS119 4.2 5.4 1.0
N2 A:0VW303 4.4 12.3 0.6
O A:HOH699 4.6 33.7 1.0
CD A:GLU106 4.9 5.5 1.0

Reference:

A.Di Pizio, J.Schulze Wischeler, M.Haake, A.Heine, C.Supuran, G.Klebe. High Resolution Crystal Structures of Carbonic Anhydrase II in Complex with Novel Sulfamide Binders To Be Published.
Page generated: Sat Oct 26 22:56:44 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy