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Atomistry » Zinc » PDB 4dz9-4eex » 4e90 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4dz9-4eex » 4e90 » |
Zinc in PDB 4e90: Human Phosphodiesterase 9 in Complex with InhibitorsEnzymatic activity of Human Phosphodiesterase 9 in Complex with Inhibitors
All present enzymatic activity of Human Phosphodiesterase 9 in Complex with Inhibitors:
3.1.4.35; Protein crystallography data
The structure of Human Phosphodiesterase 9 in Complex with Inhibitors, PDB code: 4e90
was solved by
S.Liu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4e90:
The structure of Human Phosphodiesterase 9 in Complex with Inhibitors also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Human Phosphodiesterase 9 in Complex with Inhibitors
(pdb code 4e90). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Phosphodiesterase 9 in Complex with Inhibitors, PDB code: 4e90: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 4e90Go back to Zinc Binding Sites List in 4e90
Zinc binding site 1 out
of 2 in the Human Phosphodiesterase 9 in Complex with Inhibitors
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 4e90Go back to Zinc Binding Sites List in 4e90
Zinc binding site 2 out
of 2 in the Human Phosphodiesterase 9 in Complex with Inhibitors
Mono view Stereo pair view
Reference:
M.M.Claffey,
C.J.Helal,
P.R.Verhoest,
Z.Kang,
K.S.Fors,
S.Jung,
J.Zhong,
M.W.Bundesmann,
X.Hou,
S.Lui,
R.J.Kleiman,
M.Vanase-Frawley,
A.W.Schmidt,
F.Menniti,
C.J.Schmidt,
W.E.Hoffman,
M.Hajos,
L.Mcdowell,
R.E.O'connor,
M.Macdougall-Murphy,
K.R.Fonseca,
S.L.Becker,
F.R.Nelson,
S.Liras.
Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, in Vivo Active Phosphodiesterase 9A Inhibitors. J.Med.Chem. V. 55 9055 2012.
Page generated: Sat Oct 26 21:56:12 2024
ISSN: ISSN 0022-2623 PubMed: 23025719 DOI: 10.1021/JM3009635 |
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