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Zinc in PDB 4e45: Crystal Structure of the HMHF1/HMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase Hfancm

Enzymatic activity of Crystal Structure of the HMHF1/HMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase Hfancm

All present enzymatic activity of Crystal Structure of the HMHF1/HMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase Hfancm:
3.6.4.13;

Protein crystallography data

The structure of Crystal Structure of the HMHF1/HMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase Hfancm, PDB code: 4e45 was solved by D.Fox Iii, Y.Zhao, W.Yang, W.Weidong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.51 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 110.980, 69.970, 116.050, 90.00, 91.60, 90.00
R / Rfree (%) 20.2 / 24.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the HMHF1/HMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase Hfancm (pdb code 4e45). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of the HMHF1/HMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase Hfancm, PDB code: 4e45:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in 4e45

Go back to Zinc Binding Sites List in 4e45
Zinc binding site 1 out of 3 in the Crystal Structure of the HMHF1/HMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase Hfancm


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the HMHF1/HMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase Hfancm within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn101

b:38.7
occ:0.50
 OD1 D:ASP80 2.0 26.2 1.0
SG E:CYS755 2.3 26.1 1.0
ND1 E:HIS751 2.3 28.0 1.0
OD2 D:ASP80 2.4 31.8 1.0
CG D:ASP80 2.4 28.4 1.0
O D:GLN76 2.5 28.7 1.0
CB E:CYS755 3.1 24.8 1.0
CE1 E:HIS751 3.2 28.1 1.0
CG E:HIS751 3.2 27.4 1.0
C D:GLN76 3.3 27.7 1.0
CB D:GLN76 3.5 24.4 1.0
CB E:HIS751 3.6 25.9 1.0
CA D:GLN76 3.6 25.2 1.0
CA E:HIS751 3.8 23.2 1.0
CB D:ASP80 3.8 27.5 1.0
NH1 D:ARG52 4.1 23.0 1.0
N D:ASP80 4.2 24.0 1.0
NE2 E:HIS751 4.2 29.8 1.0
CD2 E:HIS751 4.3 29.0 1.0
N E:SER752 4.4 24.1 1.0
CA D:ASP80 4.4 27.6 1.0
CG D:GLN76 4.4 21.2 1.0
N D:LEU77 4.4 22.0 1.0
CA E:CYS755 4.5 23.6 1.0
OE1 D:GLN76 4.7 22.4 1.0
C E:HIS751 4.7 25.7 1.0
N E:HIS751 4.8 24.1 1.0
NH2 D:ARG52 4.8 20.5 1.0
C D:LEU79 4.8 23.5 1.0
CB D:LEU79 4.9 19.6 1.0
CA D:LEU77 4.9 22.7 1.0
CZ D:ARG52 4.9 20.9 1.0

Zinc binding site 2 out of 3 in 4e45

Go back to Zinc Binding Sites List in 4e45
Zinc binding site 2 out of 3 in the Crystal Structure of the HMHF1/HMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase Hfancm


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the HMHF1/HMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase Hfancm within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Zn901

b:37.8
occ:0.50
 OD1 I:ASP80 1.8 31.3 1.0
ND1 J:HIS751 2.2 33.7 1.0
CG I:ASP80 2.3 34.1 1.0
SG J:CYS755 2.3 27.3 1.0
OD2 I:ASP80 2.3 31.2 1.0
O I:GLN76 2.5 29.7 1.0
CB J:CYS755 3.0 26.5 1.0
CG J:HIS751 3.0 34.8 1.0
CE1 J:HIS751 3.2 37.8 1.0
CB J:HIS751 3.3 32.2 1.0
C I:GLN76 3.4 25.0 1.0
CA J:HIS751 3.5 31.0 1.0
CB I:ASP80 3.6 33.2 1.0
CB I:GLN76 3.7 22.8 1.0
CA I:GLN76 3.7 24.0 1.0
N I:ASP80 4.1 29.3 1.0
N J:SER752 4.2 30.3 1.0
NH1 I:ARG52 4.2 30.1 1.0
CA I:ASP80 4.2 31.6 1.0
CD2 J:HIS751 4.2 36.5 1.0
NE2 J:HIS751 4.3 39.2 1.0
C J:HIS751 4.4 31.7 1.0
CA J:CYS755 4.5 25.9 1.0
N I:LEU77 4.5 23.5 1.0
CG I:GLN76 4.6 22.9 1.0
N J:HIS751 4.6 31.3 1.0
C I:LEU79 4.7 27.3 1.0
NH2 I:ARG52 4.8 26.7 1.0
OE1 I:GLN76 4.8 26.3 1.0
OG J:SER752 4.9 25.8 1.0
CB I:LEU79 4.9 25.1 1.0
CZ I:ARG52 5.0 27.1 1.0
CA I:LEU77 5.0 23.5 1.0

Zinc binding site 3 out of 3 in 4e45

Go back to Zinc Binding Sites List in 4e45
Zinc binding site 3 out of 3 in the Crystal Structure of the HMHF1/HMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase Hfancm


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the HMHF1/HMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase Hfancm within 5.0Å range:
probe atom residue distance (Å) B Occ
N:Zn101

b:44.4
occ:0.50
 OD1 N:ASP80 1.9 31.9 1.0
OD2 N:ASP80 2.2 41.0 1.0
CG N:ASP80 2.3 34.9 1.0
SG O:CYS755 2.3 32.3 1.0
O N:GLN76 2.4 32.6 1.0
ND1 O:HIS751 2.5 38.1 1.0
CB O:CYS755 3.1 29.9 1.0
C N:GLN76 3.3 30.6 1.0
CG O:HIS751 3.4 36.6 1.0
CE1 O:HIS751 3.4 38.5 1.0
CB O:HIS751 3.6 38.0 1.0
CB N:GLN76 3.6 32.1 1.0
CA N:GLN76 3.6 31.3 1.0
CA O:HIS751 3.7 39.5 1.0
CB N:ASP80 3.7 35.5 1.0
N N:ASP80 4.2 31.1 1.0
NH1 N:ARG52 4.2 35.0 1.0
N O:SER752 4.3 35.8 1.0
CA N:ASP80 4.3 35.7 1.0
CG N:GLN76 4.4 30.2 1.0
N N:LEU77 4.5 32.5 1.0
CA O:CYS755 4.5 28.4 1.0
CD2 O:HIS751 4.5 36.4 1.0
NE2 O:HIS751 4.5 37.7 1.0
C O:HIS751 4.5 36.9 1.0
N O:HIS751 4.7 41.4 1.0
OE1 N:GLN76 4.8 30.1 1.0
C N:LEU79 4.8 31.3 1.0
CB N:LEU79 4.9 27.6 1.0
CA N:LEU77 4.9 29.4 1.0
NH2 N:ARG52 4.9 32.9 1.0

Reference:

D.Fox Iii, Z.Yan, C.Ling, Y.Zhao, D.Y.Lee, W.Yang, W.Weidong. Crystal Structures Reveal That Fancm Remodels the Mhf Tetramer in Favor of Binding Branched Dna To Be Published.
Page generated: Wed Dec 16 05:15:39 2020

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