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Zinc in PDB 4d7o: Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(4-(((3-Fluorophenethyl)Amino)Methyl) Phenyl)-4-Methylpyridin-2-Amine

Enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(4-(((3-Fluorophenethyl)Amino)Methyl) Phenyl)-4-Methylpyridin-2-Amine

All present enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(4-(((3-Fluorophenethyl)Amino)Methyl) Phenyl)-4-Methylpyridin-2-Amine:
1.14.13.39;

Protein crystallography data

The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(4-(((3-Fluorophenethyl)Amino)Methyl) Phenyl)-4-Methylpyridin-2-Amine, PDB code: 4d7o was solved by H.Li, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 92.07 / 1.78
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 51.770, 110.600, 165.162, 90.00, 90.00, 90.00
R / Rfree (%) 17.942 / 20.921

Other elements in 4d7o:

The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(4-(((3-Fluorophenethyl)Amino)Methyl) Phenyl)-4-Methylpyridin-2-Amine also contains other interesting chemical elements:

Fluorine (F) 2 atoms
Iron (Fe) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(4-(((3-Fluorophenethyl)Amino)Methyl) Phenyl)-4-Methylpyridin-2-Amine (pdb code 4d7o). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(4-(((3-Fluorophenethyl)Amino)Methyl) Phenyl)-4-Methylpyridin-2-Amine, PDB code: 4d7o:

Zinc binding site 1 out of 1 in 4d7o

Go back to Zinc Binding Sites List in 4d7o
Zinc binding site 1 out of 1 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(4-(((3-Fluorophenethyl)Amino)Methyl) Phenyl)-4-Methylpyridin-2-Amine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(4-(((3-Fluorophenethyl)Amino)Methyl) Phenyl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn900

b:27.1
occ:1.00
 SG B:CYS326 2.4 30.7 1.0
SG A:CYS331 2.4 29.3 1.0
SG B:CYS331 2.4 29.0 1.0
SG A:CYS326 2.4 31.1 1.0
CB A:CYS331 3.3 30.6 1.0
CB B:CYS331 3.3 30.2 1.0
CB A:CYS326 3.4 34.3 1.0
CB B:CYS326 3.4 35.4 1.0
CA B:CYS331 3.6 30.4 1.0
CA A:CYS331 3.6 32.2 1.0
N A:MET332 3.9 33.0 1.0
N B:MET332 3.9 29.1 1.0
N A:GLY333 4.1 29.1 1.0
N B:GLY333 4.1 27.3 1.0
C B:CYS331 4.2 29.9 1.0
C A:CYS331 4.2 32.5 1.0
CA A:GLY333 4.5 28.5 1.0
CA B:GLY333 4.5 27.4 1.0
CA B:CYS326 4.7 36.6 1.0
CA A:CYS326 4.7 36.5 1.0
N B:CYS331 4.8 31.9 1.0
N A:CYS331 4.9 33.2 1.0
C B:MET332 4.9 29.5 1.0
O B:ILE330 4.9 35.2 1.0
C A:MET332 4.9 31.4 1.0

Reference:

J.K.Holden, S.Kang, F.C.Beasley, M.A.Cinelli, H.Li, S.G.Roy, D.Dejam, A.L.Edinger, V.Nizet, R.B.Silverman, T.L.Poulos. Nitric Oxide Synthase As A Target For Methicillin-Resistant Staphylococcus Aureus Chem.Biol. V. 22 785 2015.
ISSN: ISSN 1074-5521
PubMed: 26091171
DOI: 10.1016/J.CHEMBIOL.2015.05.013
Page generated: Sat Oct 26 21:20:35 2024

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