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Atomistry » Zinc » PDB 4cxv-4d7v » 4d09 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4cxv-4d7v » 4d09 » |
Zinc in PDB 4d09: PDE2A Catalytic Domain in Complex with A Brain Penetrant InhibitorEnzymatic activity of PDE2A Catalytic Domain in Complex with A Brain Penetrant Inhibitor
All present enzymatic activity of PDE2A Catalytic Domain in Complex with A Brain Penetrant Inhibitor:
3.1.4.17; Protein crystallography data
The structure of PDE2A Catalytic Domain in Complex with A Brain Penetrant Inhibitor, PDB code: 4d09
was solved by
P.Buijnsters,
J.I.Andres,
M.Deangelis,
X.Langlois,
F.Rombouts,
W.Sanderson,
G.Tresadern,
A.Trabanco,
G.Vanhoof,
Y.Vanroosbroeck,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4d09:
The structure of PDE2A Catalytic Domain in Complex with A Brain Penetrant Inhibitor also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the PDE2A Catalytic Domain in Complex with A Brain Penetrant Inhibitor
(pdb code 4d09). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the PDE2A Catalytic Domain in Complex with A Brain Penetrant Inhibitor, PDB code: 4d09: Jump to Zinc binding site number: 1; 2; 3; 4; Zinc binding site 1 out of 4 in 4d09Go back to Zinc Binding Sites List in 4d09
Zinc binding site 1 out
of 4 in the PDE2A Catalytic Domain in Complex with A Brain Penetrant Inhibitor
Mono view Stereo pair view
Zinc binding site 2 out of 4 in 4d09Go back to Zinc Binding Sites List in 4d09
Zinc binding site 2 out
of 4 in the PDE2A Catalytic Domain in Complex with A Brain Penetrant Inhibitor
Mono view Stereo pair view
Zinc binding site 3 out of 4 in 4d09Go back to Zinc Binding Sites List in 4d09
Zinc binding site 3 out
of 4 in the PDE2A Catalytic Domain in Complex with A Brain Penetrant Inhibitor
Mono view Stereo pair view
Zinc binding site 4 out of 4 in 4d09Go back to Zinc Binding Sites List in 4d09
Zinc binding site 4 out
of 4 in the PDE2A Catalytic Domain in Complex with A Brain Penetrant Inhibitor
Mono view Stereo pair view
Reference:
P.Buijnsters,
M.De Angelis,
X.Langlois,
F.J.R.Rombouts,
W.Sanderson,
G.Tresadern,
A.Ritchie,
A.A.Trabanco,
G.Vanhoof,
Y.V.Roosbroeck,
J.Andres.
Structure-Based Design of A Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target Engagement. Acs Med.Chem.Lett. V. 5 1049 2014.
Page generated: Sat Oct 26 21:12:12 2024
ISSN: ISSN 1948-5875 PubMed: 25221665 DOI: 10.1021/ML500262U |
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