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Atomistry » Zinc » PDB 4csh-4cxp » 4ctz » |
Zinc in PDB 4ctz: Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (S)-6-(2-Amino-2-(3-(2-(4-Methylpyridin-2-Yl) Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-AmineEnzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (S)-6-(2-Amino-2-(3-(2-(4-Methylpyridin-2-Yl) Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine
All present enzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (S)-6-(2-Amino-2-(3-(2-(4-Methylpyridin-2-Yl) Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine:
1.14.13.39; Protein crystallography data
The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (S)-6-(2-Amino-2-(3-(2-(4-Methylpyridin-2-Yl) Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine, PDB code: 4ctz
was solved by
G.Chreifi,
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4ctz:
The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (S)-6-(2-Amino-2-(3-(2-(4-Methylpyridin-2-Yl) Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (S)-6-(2-Amino-2-(3-(2-(4-Methylpyridin-2-Yl) Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine
(pdb code 4ctz). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (S)-6-(2-Amino-2-(3-(2-(4-Methylpyridin-2-Yl) Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine, PDB code: 4ctz: Zinc binding site 1 out of 1 in 4ctzGo back to Zinc Binding Sites List in 4ctz
Zinc binding site 1 out
of 1 in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (S)-6-(2-Amino-2-(3-(2-(4-Methylpyridin-2-Yl) Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine
Mono view Stereo pair view
Reference:
S.Kang,
W.Tang,
H.Li,
G.Chreifi,
P.Martasek,
L.J.Roman,
T.L.Poulos,
R.B.Silverman.
Nitric Oxide Synthase Inhibitors That Interact with Both A Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity. J.Med.Chem. V. 57 4382 2014.
Page generated: Wed Dec 16 05:09:34 2020
ISSN: ISSN 0022-2623 PubMed: 24758147 DOI: 10.1021/JM5004182 |
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