Zinc in PDB 4cos: Crystal Structure of the Phd-Bromo-Pwwp Cassette of Human PRKCBP1

The structure of Crystal Structure of the Phd-Bromo-Pwwp Cassette of Human PRKCBP1, PDB code: 4cos was solved by T.Krojer, P.Savitsky, J.A.Newman, C.D.O.Cooper, F.Von Delft, C.H.Arrowsmith, C.Bountra, A.Edwards, P.Filippakopoulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.20 / 1.67
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	66.955, 68.835, 70.350, 90.00, 90.00, 90.00
R / Rfree (%)	17.589 / 21.039

The binding sites of Zinc atom in the Crystal Structure of the Phd-Bromo-Pwwp Cassette of Human PRKCBP1 (pdb code 4cos). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of the Phd-Bromo-Pwwp Cassette of Human PRKCBP1, PDB code: 4cos:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Crystal Structure of the Phd-Bromo-Pwwp Cassette of Human PRKCBP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Phd-Bromo-Pwwp Cassette of Human PRKCBP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1400 b:22.4 occ:1.00 NE2 A:HIS278 2.1 21.9 1.0 SG A:CYS258 2.3 28.2 1.0 SG A:CYS255 2.3 22.6 1.0 SG A:CYS274 2.3 25.8 1.0 CD2 A:HIS278 2.9 21.2 1.0 CE1 A:HIS278 3.2 23.1 1.0 CB A:CYS255 3.3 23.2 1.0 CB A:CYS274 3.3 26.1 1.0 CB A:CYS258 3.4 24.5 1.0 N A:CYS258 3.6 22.2 1.0 CA A:CYS258 3.9 23.3 1.0 CG A:HIS278 4.1 21.0 1.0 ND1 A:HIS278 4.2 22.3 1.0 O A:HOH2215 4.2 46.9 1.0 O A:HOH2224 4.3 23.4 1.0 CB A:GLU257 4.5 27.1 1.0 C A:GLU257 4.5 21.8 1.0 CA A:CYS255 4.7 22.9 1.0 CA A:CYS274 4.8 26.7 1.0 O A:HOH2223 4.8 41.4 1.0 CA A:GLU257 4.9 23.7 1.0 O A:CYS255 5.0 22.7 1.0 C A:CYS255 5.0 23.1 1.0

Zinc binding site 2 out of 3 in the Crystal Structure of the Phd-Bromo-Pwwp Cassette of Human PRKCBP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Phd-Bromo-Pwwp Cassette of Human PRKCBP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1401 b:23.8 occ:1.00 ND1 A:HIS111 2.1 24.2 1.0 SG A:CYS94 2.3 25.9 1.0 SG A:CYS114 2.3 27.5 1.0 SG A:CYS91 2.3 24.0 1.0 CE1 A:HIS111 3.0 25.4 1.0 CB A:CYS91 3.1 21.8 1.0 CG A:HIS111 3.1 23.6 1.0 CB A:CYS94 3.3 25.3 1.0 CB A:CYS114 3.4 26.5 1.0 CB A:HIS111 3.5 23.7 1.0 N A:CYS94 3.8 22.3 1.0 O A:HOH2035 4.1 44.3 1.0 CA A:CYS94 4.1 24.4 1.0 N A:HIS111 4.2 22.6 1.0 NE2 A:HIS111 4.2 24.1 1.0 CD2 A:HIS111 4.2 24.8 1.0 CA A:HIS111 4.4 22.9 1.0 CA A:CYS91 4.5 22.4 1.0 CB A:VAL93 4.6 24.4 1.0 CA A:CYS114 4.7 27.4 1.0 O A:HOH2036 4.7 30.7 1.0 C A:VAL93 4.8 24.7 1.0 C A:CYS94 4.9 23.0 1.0 C A:CYS91 5.0 22.7 1.0

Zinc binding site 3 out of 3 in the Crystal Structure of the Phd-Bromo-Pwwp Cassette of Human PRKCBP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the Phd-Bromo-Pwwp Cassette of Human PRKCBP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1402 b:28.5 occ:1.00 SG A:CYS106 2.3 29.9 1.0 SG A:CYS127 2.3 29.4 1.0 SG A:CYS103 2.3 31.6 1.0 SG A:CYS130 2.3 33.0 1.0 CB A:CYS103 3.3 33.0 1.0 CB A:CYS130 3.3 32.8 1.0 CB A:CYS106 3.4 32.8 1.0 CB A:CYS127 3.4 30.9 1.0 N A:CYS127 3.8 36.0 1.0 N A:CYS106 3.8 34.8 1.0 N A:CYS130 4.1 30.1 1.0 CA A:CYS106 4.2 33.4 1.0 CA A:CYS127 4.2 32.5 1.0 CA A:CYS130 4.3 33.0 1.0 NH1 A:ARG108 4.6 23.5 1.0 CB A:LEU105 4.6 44.5 1.0 C A:CYS106 4.7 30.5 1.0 C A:LEU105 4.7 41.8 1.0 O A:CYS127 4.7 32.8 1.0 CA A:CYS103 4.7 32.5 1.0 O A:CYS106 4.7 32.4 1.0 C A:CYS127 4.7 32.6 1.0 CB A:ARG108 4.8 24.2 1.0 CD A:ARG108 4.9 22.4 1.0 C A:PHE126 4.9 37.8 1.0 N A:LEU105 5.0 45.5 1.0 CA A:LEU105 5.0 42.0 1.0

P.Filippakopoulos, T.Krojer, P.Savitsky, J.A.Newman, C.D.O.Cooper, F.Von Delft, C.H.Arrowsmith, C.Bountra, A.Edwards, P.Filippakopoulos. N/A N/A.