Zinc in PDB 4bup: A Novel Route to Product Specificity in the SUV4-20 Family of Histone H4K20 Methyltransferases

All present enzymatic activity of A Novel Route to Product Specificity in the SUV4-20 Family of Histone H4K20 Methyltransferases:
2.1.1.43;

The structure of A Novel Route to Product Specificity in the SUV4-20 Family of Histone H4K20 Methyltransferases, PDB code: 4bup was solved by S.M.Southall, N.B.Cronin, J.R.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.640 / 2.17
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	46.310, 50.010, 129.400, 90.00, 92.82, 90.00
R / Rfree (%)	19.8 / 25.94

The binding sites of Zinc atom in the A Novel Route to Product Specificity in the SUV4-20 Family of Histone H4K20 Methyltransferases (pdb code 4bup). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the A Novel Route to Product Specificity in the SUV4-20 Family of Histone H4K20 Methyltransferases, PDB code: 4bup:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the A Novel Route to Product Specificity in the SUV4-20 Family of Histone H4K20 Methyltransferases


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of A Novel Route to Product Specificity in the SUV4-20 Family of Histone H4K20 Methyltransferases within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn400 b:22.1 occ:1.00 SG A:CYS313 2.3 18.1 1.0 SG A:CYS311 2.4 16.8 1.0 SG A:CYS267 2.4 21.0 1.0 SG A:CYS316 2.4 25.9 1.0 CB A:CYS316 3.3 25.7 1.0 CB A:CYS311 3.3 19.2 1.0 CB A:CYS267 3.4 24.4 1.0 CB A:CYS313 3.5 17.5 1.0 N A:CYS267 4.0 15.6 1.0 N A:CYS316 4.0 21.8 1.0 O A:HOH2091 4.1 32.3 1.0 N A:CYS313 4.1 17.5 1.0 CA A:CYS316 4.2 24.8 1.0 NE2 A:HIS265 4.2 18.1 1.0 CA A:CYS267 4.3 18.1 1.0 CA A:CYS313 4.3 20.9 1.0 CD2 A:HIS265 4.4 17.5 1.0 CA A:CYS311 4.6 21.6 1.0 C A:CYS311 4.6 21.8 1.0 O A:CYS311 4.8 25.1 1.0 C A:CYS313 4.8 22.6 1.0 O A:CYS313 4.9 18.0 1.0 C A:ASP266 4.9 16.2 1.0

Zinc binding site 2 out of 2 in the A Novel Route to Product Specificity in the SUV4-20 Family of Histone H4K20 Methyltransferases


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of A Novel Route to Product Specificity in the SUV4-20 Family of Histone H4K20 Methyltransferases within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn400 b:27.6 occ:1.00 SG B:CYS313 2.2 19.8 1.0 SG B:CYS267 2.3 27.0 1.0 SG B:CYS311 2.4 24.6 1.0 SG B:CYS316 2.6 26.9 1.0 CB B:CYS316 3.2 29.6 1.0 CB B:CYS267 3.3 28.7 1.0 CB B:CYS311 3.4 27.0 1.0 CB B:CYS313 3.4 24.1 1.0 N B:CYS267 3.9 21.1 1.0 N B:CYS316 4.0 28.9 1.0 N B:CYS313 4.1 24.2 1.0 CA B:CYS316 4.1 32.2 1.0 CA B:CYS267 4.2 20.9 1.0 CA B:CYS313 4.2 26.7 1.0 NE2 B:HIS265 4.3 19.6 1.0 CD2 B:HIS265 4.4 23.5 1.0 O B:HOH2080 4.5 33.6 1.0 O B:CYS313 4.6 27.0 1.0 O B:HOH2096 4.6 27.0 1.0 CA B:CYS311 4.6 24.8 1.0 C B:CYS311 4.6 25.4 1.0 C B:CYS313 4.7 26.6 1.0 O B:CYS311 4.8 27.5 1.0 C B:ASP266 4.9 21.6 1.0 NH2 B:ARG319 5.0 37.9 1.0

S.M.Southall, N.B.Cronin, J.R.Wilson. A Novel Route to Product Specificity in the SUV4-20 Family of Histone H4K20 Methyltransferases. Nucleic Acids Res. V. 42 661 2014.
ISSN: ISSN 0305-1048
PubMed: 24049080
DOI: 10.1093/NAR/GKT776