Atomistry » Zinc » PDB 4are-4b3r » 4ax1
Atomistry »
  Zinc »
    PDB 4are-4b3r »
      4ax1 »

Zinc in PDB 4ax1: Q157N Mutant. Crystal Structure of the Mobile Metallo-Beta-Lactamase Aim-1 From Pseudomonas Aeruginosa: Insights Into Antibiotic Binding and the Role of GLN157

Protein crystallography data

The structure of Q157N Mutant. Crystal Structure of the Mobile Metallo-Beta-Lactamase Aim-1 From Pseudomonas Aeruginosa: Insights Into Antibiotic Binding and the Role of GLN157, PDB code: 4ax1 was solved by H.-K.S.Leiros, P.S.Borra, B.O.Brandsdal, K.S.W.Edvardsen, J.Spencer, T.R.Walsh, O.Samuelsen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 1.40
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 77.992, 77.992, 239.766, 90.00, 90.00, 120.00
R / Rfree (%) 13 / 15

Other elements in 4ax1:

The structure of Q157N Mutant. Crystal Structure of the Mobile Metallo-Beta-Lactamase Aim-1 From Pseudomonas Aeruginosa: Insights Into Antibiotic Binding and the Role of GLN157 also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Calcium (Ca) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Q157N Mutant. Crystal Structure of the Mobile Metallo-Beta-Lactamase Aim-1 From Pseudomonas Aeruginosa: Insights Into Antibiotic Binding and the Role of GLN157 (pdb code 4ax1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Q157N Mutant. Crystal Structure of the Mobile Metallo-Beta-Lactamase Aim-1 From Pseudomonas Aeruginosa: Insights Into Antibiotic Binding and the Role of GLN157, PDB code: 4ax1:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4ax1

Go back to Zinc Binding Sites List in 4ax1
Zinc binding site 1 out of 2 in the Q157N Mutant. Crystal Structure of the Mobile Metallo-Beta-Lactamase Aim-1 From Pseudomonas Aeruginosa: Insights Into Antibiotic Binding and the Role of GLN157


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Q157N Mutant. Crystal Structure of the Mobile Metallo-Beta-Lactamase Aim-1 From Pseudomonas Aeruginosa: Insights Into Antibiotic Binding and the Role of GLN157 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn3228

b:11.1
occ:1.00
O B:HOH2149 1.9 15.8 1.0
NE2 B:HIS196 2.0 9.2 1.0
NE2 B:HIS116 2.1 9.2 1.0
ND1 B:HIS118 2.1 11.4 1.0
CD2 B:HIS196 2.9 9.3 1.0
CD2 B:HIS116 3.0 8.9 1.0
O B:HOH2150 3.0 14.1 1.0
CE1 B:HIS118 3.0 11.0 1.0
CE1 B:HIS116 3.0 11.3 1.0
CG B:HIS118 3.1 10.8 1.0
CE1 B:HIS196 3.1 10.3 1.0
ZN B:ZN3229 3.5 12.8 1.0
CB B:HIS118 3.5 10.1 1.0
O B:HOH2408 3.9 38.1 1.0
ND1 B:HIS116 4.1 10.5 1.0
CD2 B:HIS121 4.1 10.7 1.0
CG B:HIS116 4.1 9.4 1.0
OD1 B:ASP120 4.1 11.7 1.0
CG B:HIS196 4.1 10.1 1.0
NE2 B:HIS118 4.2 11.4 1.0
ND1 B:HIS196 4.2 11.3 1.0
NE2 B:HIS121 4.2 9.5 1.0
CD2 B:HIS118 4.3 11.5 1.0
O B:HOH2163 4.4 30.9 1.0
OG B:SER221 4.8 10.7 1.0
OD2 B:ASP120 4.8 12.3 1.0
O B:HOH2293 4.8 17.9 1.0
CG B:ASP120 4.9 11.2 1.0
CB B:SER221 4.9 9.4 1.0
CG2 B:THR197 5.0 13.7 1.0
CA B:HIS118 5.0 9.8 1.0

Zinc binding site 2 out of 2 in 4ax1

Go back to Zinc Binding Sites List in 4ax1
Zinc binding site 2 out of 2 in the Q157N Mutant. Crystal Structure of the Mobile Metallo-Beta-Lactamase Aim-1 From Pseudomonas Aeruginosa: Insights Into Antibiotic Binding and the Role of GLN157


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Q157N Mutant. Crystal Structure of the Mobile Metallo-Beta-Lactamase Aim-1 From Pseudomonas Aeruginosa: Insights Into Antibiotic Binding and the Role of GLN157 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn3229

b:12.8
occ:1.00
O B:HOH2149 2.0 15.8 1.0
NE2 B:HIS263 2.0 9.3 1.0
NE2 B:HIS121 2.0 9.5 1.0
OD2 B:ASP120 2.1 12.3 1.0
O B:HOH2150 2.3 14.1 1.0
CG B:ASP120 3.0 11.2 1.0
CD2 B:HIS121 3.0 10.7 1.0
CD2 B:HIS263 3.0 9.9 1.0
CE1 B:HIS121 3.0 10.1 1.0
CE1 B:HIS263 3.1 11.4 1.0
OD1 B:ASP120 3.3 11.7 1.0
ZN B:ZN3228 3.5 11.1 1.0
O B:HOH2408 3.6 38.1 1.0
ND1 B:HIS121 4.1 11.2 1.0
ND1 B:HIS263 4.1 10.6 1.0
NE2 B:HIS116 4.1 9.2 1.0
CG B:HIS121 4.2 9.9 1.0
CG B:HIS263 4.2 10.3 1.0
O B:HOH2293 4.3 17.9 1.0
CE1 B:HIS116 4.3 11.3 1.0
CB B:ASP120 4.3 12.3 1.0
O B:HOH2143 4.5 44.1 1.0
OG B:SER221 4.5 10.7 1.0
O B:HOH2163 4.7 30.9 1.0
CD1 B:ILE68 4.8 12.6 1.0
NE2 B:HIS196 4.8 9.2 1.0

Reference:

H.-K.S.Leiros, P.S.Borra, B.O.Brandsdal, K.S.W.Edvardsen, J.Spencer, T.R.Walsh, O.Samuelsen. Crystal Structure of the Mobile Metallo-Beta-Lactamase Aim-1 From Pseudomonas Aeruginosa: Insights Into Antibiotic Binding and the Role of GLN157 Antimicrob.Agents Chemother. V. 56 4341 2012.
ISSN: ISSN 0066-4804
PubMed: 22664968
DOI: 10.1128/AAC.00448-12
Page generated: Sat Oct 26 19:27:04 2024

Last articles

Zn in 9FD2
Zn in 9GUW
Zn in 9GUX
Zn in 9F7C
Zn in 9GUR
Zn in 9F7A
Zn in 9DDE
Zn in 9DBY
Zn in 9EBZ
Zn in 9DGG
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy