Zinc in PDB 4aa6: The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation

Protein crystallography data

The structure of The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation, PDB code: 4aa6 was solved by J.W.Schwabe, L.Chapman, D.Rhodes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 7.00 / 2.60
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 121.677, 113.093, 62.363, 90.00, 117.45, 90.00
R / Rfree (%) 22.2 / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation (pdb code 4aa6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation, PDB code: 4aa6:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Zinc binding site 1 out of 8 in 4aa6

Go back to Zinc Binding Sites List in 4aa6
Zinc binding site 1 out of 8 in the The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn253

b:15.3
occ:1.00
 SG A:CYS205 2.2 8.6 1.0
SG A:CYS185 2.3 17.1 1.0
SG A:CYS188 2.3 15.6 1.0
SG A:CYS202 2.3 16.1 1.0
H A:CYS202 3.0 15.0 1.0
H A:CYS188 3.1 15.0 1.0
H A:CYS205 3.2 15.0 1.0
CB A:CYS185 3.2 13.5 1.0
CB A:CYS205 3.3 12.6 1.0
CB A:CYS188 3.4 11.8 1.0
CB A:CYS202 3.5 12.3 1.0
HH11 A:ARG234 3.5 15.0 1.0
HH21 A:ARG241 3.7 15.0 1.0
N A:CYS188 3.8 14.0 1.0
N A:CYS202 3.9 17.2 1.0
N A:CYS205 3.9 11.9 1.0
H A:ASP190 4.0 15.0 1.0
NH1 A:ARG234 4.1 11.1 1.0
CA A:CYS188 4.2 7.7 1.0
H1 A:HOH2009 4.2 20.0 1.0
CA A:CYS205 4.2 10.4 1.0
HH12 A:ARG234 4.3 15.0 1.0
CA A:CYS202 4.3 14.8 1.0
H A:VAL187 4.3 15.0 1.0
CB A:VAL187 4.5 5.9 1.0
HE A:ARG241 4.6 15.0 1.0
CA A:CYS185 4.7 16.3 1.0
H A:ASN189 4.7 15.0 1.0
CB A:ASP190 4.7 10.1 1.0
NH2 A:ARG241 4.7 6.8 1.0
C A:VAL187 4.7 12.8 1.0
C A:CYS188 4.8 10.8 1.0
C A:CYS202 4.9 14.9 1.0
O A:CYS202 4.9 14.2 1.0
CD A:ARG234 4.9 9.2 1.0
N A:ASP190 4.9 10.9 1.0
CA A:VAL187 5.0 9.0 1.0
N A:ASN189 5.0 8.8 1.0
N A:VAL187 5.0 14.6 1.0

Zinc binding site 2 out of 8 in 4aa6

Go back to Zinc Binding Sites List in 4aa6
Zinc binding site 2 out of 8 in the The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn254

b:15.5
occ:1.00
 SG A:CYS227 2.2 6.6 1.0
SG A:CYS221 2.3 12.5 1.0
SG A:CYS237 2.3 14.1 1.0
SG A:CYS240 2.3 19.5 1.0
CB A:CYS221 3.3 12.9 1.0
CB A:CYS227 3.3 14.8 1.0
CB A:CYS237 3.3 17.0 1.0
H A:CYS227 3.4 15.0 1.0
CB A:CYS240 3.4 11.8 1.0
H A:CYS240 3.4 15.0 1.0
H1 A:HOH2020 3.5 20.0 1.0
H A:ASN225 3.7 15.0 1.0
H2 A:HOH2023 3.8 20.0 1.0
H A:GLN226 3.9 15.0 1.0
H A:ALA223 3.9 15.0 1.0
CA A:CYS221 4.0 14.5 1.0
CD A:PRO222 4.0 9.8 1.0
O A:HOH2020 4.1 15.7 1.0
N A:CYS227 4.1 7.8 1.0
N A:CYS240 4.2 6.8 1.0
HH12 A:ARG243 4.2 15.0 1.0
H1 A:HOH2023 4.2 20.0 1.0
CA A:ASN225 4.2 7.3 1.0
CA A:CYS227 4.3 10.8 1.0
N A:ASN225 4.3 11.9 1.0
CA A:CYS240 4.4 12.8 1.0
N A:GLN226 4.5 2.0 1.0
O A:HOH2023 4.5 10.8 1.0
N A:PRO222 4.6 13.4 1.0
CA A:CYS237 4.7 17.2 1.0
C A:CYS221 4.7 14.0 1.0
C A:ASN225 4.8 6.0 1.0
CG A:PRO222 4.8 10.9 1.0
N A:ALA223 4.9 18.1 1.0
HH11 A:ARG243 4.9 15.0 1.0
NH1 A:ARG243 4.9 5.2 1.0
H2 A:HOH2020 4.9 20.0 1.0

Zinc binding site 3 out of 8 in 4aa6

Go back to Zinc Binding Sites List in 4aa6
Zinc binding site 3 out of 8 in the The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn253

b:22.6
occ:1.00
 SG B:CYS205 2.3 18.2 1.0
SG B:CYS188 2.3 21.8 1.0
SG B:CYS185 2.3 27.1 1.0
SG B:CYS202 2.3 25.9 1.0
H B:CYS188 2.9 15.0 1.0
H B:CYS202 3.1 15.0 1.0
H B:CYS205 3.2 15.0 1.0
CB B:CYS205 3.3 15.0 1.0
CB B:CYS185 3.4 19.7 1.0
CB B:CYS188 3.4 19.0 1.0
CB B:CYS202 3.5 20.9 1.0
HH21 B:ARG241 3.6 15.0 1.0
HH11 B:ARG234 3.7 15.0 1.0
N B:CYS188 3.7 15.9 1.0
H B:ASP190 3.9 15.0 1.0
N B:CYS205 4.0 14.4 1.0
N B:CYS202 4.0 25.4 1.0
NH1 B:ARG234 4.1 21.9 1.0
CA B:CYS188 4.1 17.1 1.0
CA B:CYS205 4.3 13.6 1.0
HH12 B:ARG234 4.3 15.0 1.0
CA B:CYS202 4.3 19.2 1.0
H B:VAL187 4.4 15.0 1.0
CB B:VAL187 4.4 14.0 1.0
H B:ASN189 4.5 15.0 1.0
NH2 B:ARG241 4.6 12.6 1.0
CB B:ASP190 4.6 20.6 1.0
C B:VAL187 4.7 17.9 1.0
C B:CYS188 4.7 20.5 1.0
CD B:ARG234 4.8 12.8 1.0
HE B:ARG241 4.8 15.0 1.0
CA B:CYS185 4.8 23.0 1.0
N B:ASP190 4.8 25.4 1.0
N B:ASN189 4.8 26.6 1.0
CZ B:ARG234 4.9 11.8 1.0
CA B:VAL187 4.9 17.9 1.0
C B:CYS202 4.9 17.5 1.0
CG1 B:VAL187 4.9 10.4 1.0
HH22 B:ARG241 5.0 15.0 1.0

Zinc binding site 4 out of 8 in 4aa6

Go back to Zinc Binding Sites List in 4aa6
Zinc binding site 4 out of 8 in the The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn254

b:17.0
occ:1.00
 SG B:CYS227 2.2 6.2 1.0
SG B:CYS221 2.3 12.6 1.0
SG B:CYS237 2.3 15.2 1.0
SG B:CYS240 2.3 15.0 1.0
H B:CYS227 3.2 15.0 1.0
H1 B:HOH2012 3.3 20.0 1.0
CB B:CYS227 3.3 16.4 1.0
CB B:CYS237 3.3 12.8 1.0
CB B:CYS221 3.3 17.8 1.0
CB B:CYS240 3.4 12.1 1.0
H B:CYS240 3.4 15.0 1.0
H2 B:HOH2013 3.5 20.0 1.0
H B:GLN226 3.8 15.0 1.0
H B:ASN225 3.8 15.0 1.0
N B:CYS227 3.9 8.1 1.0
CA B:CYS221 4.0 14.4 1.0
O B:HOH2012 4.0 24.9 1.0
N B:CYS240 4.1 12.6 1.0
H1 B:HOH2013 4.2 20.0 1.0
H B:ALA223 4.2 15.0 1.0
CD B:PRO222 4.2 4.0 1.0
CA B:CYS227 4.2 12.3 1.0
CA B:ASN225 4.3 10.1 1.0
O B:HOH2013 4.3 21.5 1.0
CA B:CYS240 4.3 13.3 1.0
N B:GLN226 4.4 5.9 1.0
N B:ASN225 4.4 11.4 1.0
HH12 B:ARG243 4.5 15.0 1.0
N B:PRO222 4.6 5.4 1.0
C B:CYS221 4.7 10.8 1.0
H2 B:HOH2012 4.7 20.0 1.0
C B:ASN225 4.7 9.3 1.0
CA B:CYS237 4.7 15.7 1.0
CG B:PRO222 5.0 3.4 1.0
C B:GLN226 5.0 6.2 1.0
CB B:ALA239 5.0 2.0 1.0
N B:ALA223 5.0 10.1 1.0

Zinc binding site 5 out of 8 in 4aa6

Go back to Zinc Binding Sites List in 4aa6
Zinc binding site 5 out of 8 in the The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn253

b:22.3
occ:1.00
 SG E:CYS205 2.3 12.3 1.0
SG E:CYS188 2.3 23.8 1.0
SG E:CYS185 2.3 22.9 1.0
SG E:CYS202 2.3 22.2 1.0
H E:CYS188 3.1 15.0 1.0
H E:CYS202 3.1 15.0 1.0
H2 E:HOH2002 3.2 20.0 1.0
H E:CYS205 3.3 15.0 1.0
H1 E:HOH2002 3.3 20.0 1.0
CB E:CYS205 3.3 16.5 1.0
CB E:CYS185 3.3 22.1 1.0
CB E:CYS188 3.4 21.5 1.0
CB E:CYS202 3.5 12.2 1.0
H1 E:HOH2003 3.5 20.0 1.0
HH21 E:ARG241 3.7 15.0 1.0
N E:CYS188 3.7 21.4 1.0
O E:HOH2002 3.8 24.2 1.0
N E:CYS202 4.0 21.1 1.0
N E:CYS205 4.0 19.0 1.0
H2 E:HOH2003 4.1 20.0 1.0
H E:ASP190 4.1 15.0 1.0
CA E:CYS188 4.1 17.4 1.0
CA E:CYS205 4.3 15.4 1.0
O E:HOH2003 4.3 19.9 1.0
CA E:CYS202 4.3 14.9 1.0
H E:VAL187 4.5 15.0 1.0
CB E:VAL187 4.5 19.3 1.0
NH2 E:ARG241 4.6 2.0 1.0
CB E:ASP190 4.7 27.5 1.0
C E:CYS188 4.7 18.1 1.0
C E:VAL187 4.7 24.2 1.0
CA E:CYS185 4.7 27.3 1.0
H E:ASN189 4.7 15.0 1.0
HE E:ARG241 4.8 15.0 1.0
C E:CYS202 4.9 15.6 1.0
N E:ASP190 5.0 28.5 1.0
O E:CYS202 5.0 16.7 1.0
N E:ASN189 5.0 19.9 1.0

Zinc binding site 6 out of 8 in 4aa6

Go back to Zinc Binding Sites List in 4aa6
Zinc binding site 6 out of 8 in the The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn254

b:15.3
occ:1.00
 SG E:CYS227 2.3 7.4 1.0
SG E:CYS221 2.3 12.9 1.0
SG E:CYS237 2.3 16.8 1.0
SG E:CYS240 2.3 15.6 1.0
CB E:CYS227 3.3 13.2 1.0
H E:CYS227 3.3 15.0 1.0
CB E:CYS237 3.3 14.0 1.0
CB E:CYS221 3.4 13.1 1.0
CB E:CYS240 3.4 12.9 1.0
H E:CYS240 3.4 15.0 1.0
H1 E:HOH2014 3.5 20.0 1.0
H1 E:HOH2016 3.6 20.0 1.0
H E:ASN225 3.9 15.0 1.0
H E:ALA223 4.0 15.0 1.0
N E:CYS227 4.1 9.4 1.0
H E:GLN226 4.1 15.0 1.0
N E:CYS240 4.1 5.0 1.0
CA E:CYS221 4.1 16.8 1.0
O E:HOH2014 4.2 15.2 1.0
CA E:CYS227 4.3 8.9 1.0
CD E:PRO222 4.3 11.4 1.0
CA E:ASN225 4.3 11.1 1.0
CA E:CYS240 4.3 12.0 1.0
O E:HOH2016 4.4 2.0 1.0
N E:ASN225 4.5 17.8 1.0
N E:GLN226 4.6 6.8 1.0
HH12 E:ARG243 4.7 15.0 1.0
CA E:CYS237 4.8 10.6 1.0
C E:ASN225 4.8 9.0 1.0
N E:PRO222 4.8 11.5 1.0
C E:CYS221 4.9 16.2 1.0
CB E:ALA239 4.9 13.6 1.0
N E:ALA223 4.9 9.9 1.0
H2 E:HOH2016 5.0 20.0 1.0

Zinc binding site 7 out of 8 in 4aa6

Go back to Zinc Binding Sites List in 4aa6
Zinc binding site 7 out of 8 in the The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Zn253

b:21.1
occ:1.00
 SG F:CYS205 2.3 11.6 1.0
SG F:CYS185 2.3 20.8 1.0
SG F:CYS188 2.3 27.1 1.0
SG F:CYS202 2.3 18.4 1.0
H F:CYS188 2.9 15.0 1.0
HH11 F:ARG234 3.0 15.0 1.0
H F:CYS202 3.0 15.0 1.0
H F:CYS205 3.2 15.0 1.0
CB F:CYS185 3.3 14.7 1.0
CB F:CYS205 3.3 15.8 1.0
CB F:CYS188 3.4 23.5 1.0
CB F:CYS202 3.5 19.2 1.0
N F:CYS188 3.7 17.1 1.0
NH1 F:ARG234 3.7 54.8 1.0
HH21 F:ARG241 3.8 15.0 1.0
HH12 F:ARG234 3.9 15.0 1.0
H F:ASP190 3.9 15.0 1.0
N F:CYS202 3.9 22.1 1.0
N F:CYS205 4.0 14.5 1.0
CA F:CYS188 4.1 19.4 1.0
H2 F:HOH2002 4.2 20.0 1.0
CA F:CYS205 4.3 15.2 1.0
CA F:CYS202 4.3 16.4 1.0
H F:VAL187 4.3 15.0 1.0
H F:ASN189 4.4 15.0 1.0
CB F:VAL187 4.5 11.7 1.0
CD F:ARG234 4.6 51.1 1.0
CB F:ASP190 4.6 22.5 1.0
CA F:CYS185 4.7 15.3 1.0
C F:CYS188 4.7 21.8 1.0
C F:VAL187 4.8 18.4 1.0
HE F:ARG241 4.8 15.0 1.0
N F:ASN189 4.8 27.9 1.0
CZ F:ARG234 4.8 54.4 1.0
NH2 F:ARG241 4.8 8.6 1.0
N F:ASP190 4.8 30.7 1.0
C F:CYS202 4.9 16.1 1.0

Zinc binding site 8 out of 8 in 4aa6

Go back to Zinc Binding Sites List in 4aa6
Zinc binding site 8 out of 8 in the The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Zn254

b:16.1
occ:1.00
 SG F:CYS227 2.3 9.4 1.0
SG F:CYS221 2.3 9.2 1.0
SG F:CYS237 2.3 13.0 1.0
SG F:CYS240 2.3 12.1 1.0
CB F:CYS227 3.3 16.5 1.0
H F:CYS227 3.3 15.0 1.0
CB F:CYS221 3.3 16.6 1.0
CB F:CYS237 3.3 16.2 1.0
CB F:CYS240 3.4 11.3 1.0
H F:CYS240 3.6 15.0 1.0
H2 E:HOH2016 3.6 20.0 1.0
H1 F:HOH2010 3.6 20.0 1.0
H1 F:HOH2013 3.7 20.0 1.0
H F:ASN225 3.9 15.0 1.0
CA F:CYS221 4.0 14.3 1.0
H F:GLN226 4.0 15.0 1.0
N F:CYS227 4.1 9.4 1.0
H F:ALA223 4.1 15.0 1.0
N F:CYS240 4.2 9.0 1.0
H2 F:HOH2008 4.2 20.0 1.0
CA F:CYS227 4.3 11.9 1.0
H2 F:HOH2013 4.3 20.0 1.0
O F:HOH2010 4.3 21.7 1.0
CD F:PRO222 4.3 8.1 1.0
CA F:ASN225 4.4 15.4 1.0
O E:HOH2016 4.4 2.0 1.0
CA F:CYS240 4.4 12.0 1.0
O F:HOH2013 4.5 13.4 1.0
N F:ASN225 4.5 18.6 1.0
N F:GLN226 4.6 11.3 1.0
CA F:CYS237 4.7 25.6 1.0
N F:PRO222 4.8 5.4 1.0
C F:CYS221 4.8 10.3 1.0
C F:ASN225 4.8 13.6 1.0
CB F:ALA239 4.9 2.0 1.0

Reference:

J.W.Schwabe, L.Chapman, D.Rhodes. The Oestrogen Receptor Recognizes An Imperfectly Palindromic Response Element Through An Alternative Side-Chain Conformation. Structure V. 3 201 1995.
ISSN: ISSN 0969-2126
PubMed: 7735836
DOI: 10.1016/S0969-2126(01)00150-2
Page generated: Wed Dec 16 05:02:55 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy