Zinc in PDB 4a0x: Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus

The structure of Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus, PDB code: 4a0x was solved by D.Albanesi, M.E.Guerin, A.Buschiazzo, D.De Mendoza, P.M.Alzari, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	78.09 / 2.40
Space group	H 3 2
Cell size a, b, c (Å), α, β, γ (°)	116.580, 116.580, 123.230, 90.00, 90.00, 120.00
R / Rfree (%)	19.643 / 24.617

The binding sites of Zinc atom in the Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus (pdb code 4a0x). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus, PDB code: 4a0x:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:51.0 occ:1.00 OE2 A:GLU64 2.0 59.1 1.0 OE2 A:GLU75 2.1 52.7 1.0 OE1 A:GLU75 2.7 53.6 1.0 CD A:GLU75 2.7 51.7 1.0 CD A:GLU64 2.8 59.2 1.0 OE1 A:GLU64 2.9 57.3 1.0 CG A:GLU75 4.2 50.9 1.0 CG A:GLU64 4.3 61.6 1.0

Zinc binding site 2 out of 5 in the Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn202 b:54.5 occ:1.00 O A:ACT211 1.8 61.6 1.0 NE2 A:HIS112 2.2 43.4 1.0 C A:ACT211 2.6 61.0 1.0 OXT A:ACT211 2.8 61.4 1.0 CD2 A:HIS112 3.2 42.7 1.0 CE1 A:HIS112 3.3 43.0 1.0 CH3 A:ACT211 4.0 60.1 1.0 CG A:HIS112 4.3 43.1 1.0 ND1 A:HIS112 4.3 44.0 1.0 CG2 A:VAL113 4.5 38.9 1.0

Zinc binding site 3 out of 5 in the Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn203 b:75.3 occ:1.00 ND1 A:HIS134 2.0 71.0 1.0 NE2 A:HIS163 2.3 70.6 1.0 O A:HOH2020 2.4 20.2 1.0 O A:HOH2016 2.7 17.3 1.0 CE1 A:HIS134 2.9 72.3 1.0 CG A:HIS134 3.0 65.5 1.0 CD2 A:HIS163 3.2 65.1 1.0 CE1 A:HIS163 3.3 71.5 1.0 CB A:HIS134 3.4 59.9 1.0 NE2 A:HIS134 3.9 70.5 1.0 CD2 A:HIS134 4.0 66.9 1.0 CE A:LYS183 4.3 64.4 1.0 CG A:HIS163 4.3 66.6 1.0 ND1 A:HIS163 4.4 70.9 1.0 CD1 A:PHE185 4.5 71.8 1.0 NZ A:LYS183 4.5 68.7 1.0 CB A:PHE185 4.7 66.0 1.0 CD A:LYS183 4.8 62.2 1.0 CA A:HIS134 4.9 57.2 1.0 CG A:PHE185 5.0 69.3 1.0

Zinc binding site 4 out of 5 in the Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn204 b:52.7 occ:0.30 OE2 A:GLU31 1.9 71.0 1.0 NE2 A:HIS174 2.3 79.7 1.0 O A:HOH2004 2.6 47.3 1.0 CD A:GLU31 2.9 69.9 1.0 OE1 A:GLU31 3.1 70.3 1.0 CE1 A:HIS174 3.2 83.5 1.0 CD2 A:HIS174 3.2 74.6 1.0 ND1 A:HIS174 4.3 82.0 1.0 CG A:GLU31 4.3 69.3 1.0 CG A:HIS174 4.3 75.0 1.0 ND2 A:ASN24 4.7 67.1 1.0 O A:HOH2019 4.8 45.5 1.0

Zinc binding site 5 out of 5 in the Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Structure of the Global Transcription Regulator Fapr From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn205 b:66.2 occ:0.30 O A:HOH2003 2.2 15.3 1.0 OD2 A:ASP34 2.3 85.0 1.0 O A:HOH2002 2.5 27.2 1.0 NE2 A:HIS30 2.5 84.5 1.0 CE1 A:HIS30 3.2 86.5 1.0 CG A:ASP34 3.3 84.1 1.0 OD1 A:ASP34 3.6 88.1 1.0 CD2 A:HIS30 3.7 81.2 1.0 ND1 A:HIS30 4.4 85.0 1.0 CB A:ASP34 4.6 79.8 1.0 CG A:HIS30 4.7 80.7 1.0

D.Albanesi, G.Reh, M.E.Guerin, F.Schaeffer, M.Debarbouille, A.Buschiazzo, G.E.Schujman, D.De Mendoza, P.M.Alzari. Structural Basis For Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus Aureus. Plos Pathog. V. 9 3108 2013.
ISSN: ISSN 1553-7366
PubMed: 23300457
DOI: 10.1371/JOURNAL.PPAT.1003108