Zinc in PDB 3v43: Crystal Structure of Moz

All present enzymatic activity of Crystal Structure of Moz:
2.3.1.48;

The structure of Crystal Structure of Moz, PDB code: 3v43 was solved by Y.Qiu, F.Li, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.13 / 1.47
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	35.080, 57.630, 76.510, 90.00, 90.00, 90.00
R / Rfree (%)	15.3 / 17.6

The binding sites of Zinc atom in the Crystal Structure of Moz (pdb code 3v43). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Moz, PDB code: 3v43:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Crystal Structure of Moz


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Moz within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:10.8 occ:1.00 SG A:CYS310 2.3 13.2 1.0 SG A:CYS307 2.3 10.7 1.0 SG A:CYS281 2.3 10.7 1.0 SG A:CYS284 2.3 10.7 1.0 CB A:CYS281 3.2 10.4 1.0 CB A:CYS310 3.3 14.3 1.0 CB A:CYS284 3.4 10.0 1.0 CB A:CYS307 3.5 12.4 1.0 N A:CYS284 3.8 10.3 1.0 OG A:SER283 3.8 10.3 0.2 N A:CYS307 3.9 12.8 1.0 N A:CYS310 4.0 14.0 1.0 CA A:CYS284 4.1 9.8 1.0 CA A:CYS307 4.2 12.7 1.0 CA A:CYS310 4.3 14.5 1.0 NH1 A:ARG286 4.4 13.7 1.0 CB A:SER283 4.6 13.0 0.5 C A:SER283 4.6 11.3 1.0 CB A:SER283 4.6 11.8 0.2 O A:HOH11 4.6 16.8 1.0 CA A:CYS281 4.6 10.3 1.0 C A:CYS307 4.7 13.3 1.0 O A:CYS307 4.7 14.5 1.0 CB A:SER283 4.8 11.4 0.2 C A:CYS284 4.8 9.2 1.0 N A:SER283 4.9 11.6 1.0 CA A:SER283 4.9 12.0 0.5 CA A:SER283 4.9 11.4 0.2 CA A:SER283 5.0 11.3 0.2 N A:ASP285 5.0 8.8 1.0

Zinc binding site 2 out of 4 in the Crystal Structure of Moz


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Moz within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2 b:15.2 occ:1.00 ND1 A:HIS238 2.1 14.2 1.0 SG A:CYS241 2.3 16.7 1.0 SG A:CYS212 2.3 15.7 1.0 SG A:CYS209 2.3 13.5 1.0 CE1 A:HIS238 3.0 14.3 1.0 CB A:CYS209 3.1 14.2 1.0 CG A:HIS238 3.2 13.0 1.0 CB A:CYS241 3.3 15.7 1.0 CB A:CYS212 3.3 15.3 1.0 CB A:HIS238 3.6 12.5 1.0 N A:CYS212 3.8 15.7 1.0 N A:HIS238 4.1 12.3 1.0 CA A:CYS212 4.1 15.3 1.0 NE2 A:HIS238 4.2 14.4 1.0 CD2 A:HIS238 4.3 13.8 1.0 CA A:HIS238 4.4 12.4 1.0 CA A:CYS209 4.5 13.4 1.0 O A:HOH29 4.6 26.6 1.0 CA A:CYS241 4.6 15.6 1.0 CA A:ASN219 4.6 21.6 1.0 C A:PHE211 4.8 16.1 1.0 CB A:PHE211 4.8 16.0 1.0 C A:CYS212 4.8 15.6 1.0 N A:ARG220 4.8 24.1 1.0 CG A:ARG220 4.9 28.1 1.0 N A:CYS241 4.9 15.4 1.0 CB A:ASN219 5.0 21.3 1.0 C A:ASN219 5.0 22.7 1.0

Zinc binding site 3 out of 4 in the Crystal Structure of Moz


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Moz within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn3 b:14.5 occ:1.00 SG A:CYS233 2.3 15.6 1.0 SG A:CYS262 2.3 15.8 1.0 SG A:CYS259 2.3 13.9 1.0 SG A:CYS230 2.3 13.1 1.0 CB A:CYS230 3.2 11.8 1.0 CB A:CYS262 3.2 13.8 1.0 CB A:CYS233 3.3 15.9 1.0 CB A:CYS259 3.5 12.2 1.0 N A:CYS233 3.7 16.8 1.0 N A:CYS259 4.0 11.1 1.0 CA A:CYS233 4.0 16.1 1.0 N A:CYS262 4.2 14.5 1.0 O A:HOH33 4.2 32.2 1.0 CA A:CYS259 4.3 11.9 1.0 CA A:CYS262 4.3 14.1 1.0 O A:HOH346 4.6 44.9 1.0 CA A:CYS230 4.7 12.0 1.0 CB A:ASP232 4.7 17.1 1.0 C A:ASP232 4.7 17.5 1.0 C A:CYS233 4.7 15.8 1.0 CB A:ASN235 4.8 14.2 1.0 O A:HOH106 4.8 19.8 1.0 N A:GLY234 4.8 15.5 1.0 C A:CYS259 4.8 12.2 1.0 O A:CYS259 5.0 12.4 1.0 N A:ASN235 5.0 13.3 1.0

Zinc binding site 4 out of 4 in the Crystal Structure of Moz


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Moz within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn4 b:14.1 occ:1.00 ND1 A:HIS289 2.1 14.4 1.0 SG A:CYS268 2.3 14.5 1.0 SG A:CYS292 2.3 16.5 1.0 SG A:CYS265 2.3 11.4 1.0 CB A:CYS265 3.0 11.1 1.0 CE1 A:HIS289 3.0 15.9 1.0 CG A:HIS289 3.2 14.7 1.0 CB A:CYS292 3.3 18.0 1.0 CB A:CYS268 3.3 12.9 1.0 CB A:HIS289 3.5 13.6 1.0 N A:CYS268 3.8 11.8 1.0 N A:HIS289 4.1 12.8 1.0 CA A:CYS268 4.1 12.3 1.0 NE2 A:HIS289 4.2 15.8 1.0 CD2 A:HIS289 4.2 15.6 1.0 CA A:HIS289 4.4 13.8 1.0 O A:HOH64 4.5 21.8 1.0 CA A:CYS265 4.5 10.2 1.0 CB A:SER267 4.6 12.0 1.0 CA A:CYS292 4.7 18.7 1.0 C A:SER267 4.9 11.4 1.0 C A:CYS268 4.9 13.4 1.0 N A:ARG269 4.9 13.9 1.0

Y.Qiu, L.Liu, C.Zhao, C.Han, F.Li, J.Zhang, Y.Wang, G.Li, Y.Mei, M.Wu, J.Wu, Y.Shi. Combinatorial Readout of Unmodified H3R2 and Acetylated H3K14 By the Tandem Phd Finger of Moz Reveals A Regulatory Mechanism For HOXA9 Transcription Genes Dev. V. 26 1376 2012.
ISSN: ISSN 0890-9369
PubMed: 22713874
DOI: 10.1101/GAD.188359.112