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Zinc in PDB 3uxh: Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2
Enzymatic activity of Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2
All present enzymatic activity of Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2:
1.10.99.2;
1.10.99.2;
Protein crystallography data
The structure of Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2, PDB code: 3uxh
was solved by
M.Cushman,
A.D.Mesecar,
P.E.Fanwick,
R.Narasimha,
K.C.Jensen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 39.11 / 1.53 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 56.455, 84.064, 106.663, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 16.2 / 18.4 |
Other elements in 3uxh:
The structure of Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2 also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2
(pdb code 3uxh). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2, PDB code: 3uxh:
Jump to Zinc binding site number: 1; 2;
In total 2 binding sites of Zinc where determined in the Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2, PDB code: 3uxh:
Jump to Zinc binding site number: 1; 2;
Zinc binding site 1 out of 2 in 3uxh
Go back to
Zinc Binding Sites List in 3uxh
Zinc binding site 1 out
of 2 in the Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2 within 5.0Å range:
|
Zinc binding site 2 out of 2 in 3uxh
Go back to
Zinc Binding Sites List in 3uxh
Zinc binding site 2 out
of 2 in the Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2 within 5.0Å range:
|
Reference:
P.V.Reddy,
K.C.Jensen,
A.D.Mesecar,
P.E.Fanwick,
M.Cushman.
Design, Synthesis, and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2. J.Med.Chem. V. 55 367 2012.
ISSN: ISSN 0022-2623
PubMed: 22206487
DOI: 10.1021/JM201251C
Page generated: Sat Oct 26 17:30:54 2024
ISSN: ISSN 0022-2623
PubMed: 22206487
DOI: 10.1021/JM201251C
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