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Zinc in PDB 3ua7: Crystal Structure of the Human Fyn SH3 Domain in Complex with A Peptide From the Hepatitis C Virus NS5A-Protein

Enzymatic activity of Crystal Structure of the Human Fyn SH3 Domain in Complex with A Peptide From the Hepatitis C Virus NS5A-Protein

All present enzymatic activity of Crystal Structure of the Human Fyn SH3 Domain in Complex with A Peptide From the Hepatitis C Virus NS5A-Protein:
2.7.10.2;

Protein crystallography data

The structure of Crystal Structure of the Human Fyn SH3 Domain in Complex with A Peptide From the Hepatitis C Virus NS5A-Protein, PDB code: 3ua7 was solved by J.M.Martin-Garcia, J.Ruiz-Sanz, I.Luque, A.Camara-Artigas, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 1.50
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 51.390, 51.390, 185.590, 90.00, 90.00, 90.00
R / Rfree (%) 18.5 / 23.1

Other elements in 3ua7:

The structure of Crystal Structure of the Human Fyn SH3 Domain in Complex with A Peptide From the Hepatitis C Virus NS5A-Protein also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Sodium (Na) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Human Fyn SH3 Domain in Complex with A Peptide From the Hepatitis C Virus NS5A-Protein (pdb code 3ua7). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Human Fyn SH3 Domain in Complex with A Peptide From the Hepatitis C Virus NS5A-Protein, PDB code: 3ua7:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 3ua7

Go back to Zinc Binding Sites List in 3ua7
Zinc binding site 1 out of 2 in the Crystal Structure of the Human Fyn SH3 Domain in Complex with A Peptide From the Hepatitis C Virus NS5A-Protein


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Human Fyn SH3 Domain in Complex with A Peptide From the Hepatitis C Virus NS5A-Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1

b:17.9
occ:1.00
O2 C:FMT144 1.9 23.4 1.0
OE2 C:GLU107 2.0 19.2 1.0
ND1 C:HIS104 2.1 16.6 1.0
C C:FMT144 2.7 25.6 1.0
CD C:GLU107 2.8 15.8 1.0
CE1 C:HIS104 2.9 25.4 1.0
OE1 C:GLU107 3.0 19.7 1.0
O1 C:FMT144 3.0 29.0 1.0
CG C:HIS104 3.2 16.4 1.0
CB C:HIS104 3.6 15.1 1.0
N C:HIS104 3.7 15.4 1.0
O C:HOH6 4.0 19.3 1.0
O C:HOH154 4.1 23.9 1.0
NE2 C:HIS104 4.1 24.2 1.0
CG C:GLU107 4.2 15.0 1.0
CD2 C:HIS104 4.2 20.4 1.0
C C:PHE103 4.3 15.8 1.0
CA C:HIS104 4.3 17.4 1.0
CA C:PHE103 4.3 15.4 1.0
CG2 C:THR127 4.9 19.2 1.0

Zinc binding site 2 out of 2 in 3ua7

Go back to Zinc Binding Sites List in 3ua7
Zinc binding site 2 out of 2 in the Crystal Structure of the Human Fyn SH3 Domain in Complex with A Peptide From the Hepatitis C Virus NS5A-Protein


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Human Fyn SH3 Domain in Complex with A Peptide From the Hepatitis C Virus NS5A-Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn2

b:18.5
occ:1.00
O1 D:FMT1 1.9 21.9 1.0
OE2 D:GLU107 2.0 18.5 1.0
ND1 D:HIS104 2.1 19.5 1.0
C D:FMT1 2.8 21.9 1.0
CD D:GLU107 2.8 15.6 1.0
CE1 D:HIS104 2.9 25.8 1.0
O2 D:FMT1 3.0 25.3 1.0
OE1 D:GLU107 3.0 18.2 1.0
CG D:HIS104 3.2 19.0 1.0
CB D:HIS104 3.6 15.5 1.0
N D:HIS104 3.7 17.6 1.0
NE2 D:HIS104 4.0 26.8 1.0
O D:HOH34 4.1 21.5 1.0
C D:PHE103 4.2 17.2 1.0
CA D:PHE103 4.2 17.1 1.0
O D:HOH75 4.2 19.9 1.0
CD2 D:HIS104 4.2 21.9 1.0
CG D:GLU107 4.2 13.7 1.0
CA D:HIS104 4.3 16.4 1.0
CG2 D:THR127 4.7 17.9 1.0

Reference:

J.M.Martin-Garcia, I.Luque, J.Ruiz-Sanz, A.Camara-Artigas. The Promiscuous Binding of the Fyn SH3 Domain to A Peptide From the NS5A Protein. Acta Crystallogr.,Sect.D V. 68 1030 2012.
ISSN: ISSN 0907-4449
PubMed: 22868769
DOI: 10.1107/S0907444912019798
Page generated: Wed Dec 16 04:53:57 2020

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