Zinc in PDB 3u47: Human Carbonic Anhydrase II V143L

All present enzymatic activity of Human Carbonic Anhydrase II V143L:
4.2.1.1;

The structure of Human Carbonic Anhydrase II V143L, PDB code: 3u47 was solved by D.West, R.Mckenna, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	22.89 / 1.60
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	42.271, 41.585, 72.292, 90.00, 104.53, 90.00
R / Rfree (%)	17.9 / 21.1

The binding sites of Zinc atom in the Human Carbonic Anhydrase II V143L (pdb code 3u47). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Carbonic Anhydrase II V143L, PDB code: 3u47:

Zinc binding site 1 out of 1 in the Human Carbonic Anhydrase II V143L


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Carbonic Anhydrase II V143L within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn262 b:9.0 occ:1.00 O A:HOH268 2.0 8.0 1.0 NE2 A:HIS96 2.0 6.1 1.0 NE2 A:HIS94 2.1 8.0 1.0 ND1 A:HIS119 2.1 6.4 1.0 CD2 A:HIS94 2.9 7.1 1.0 CE1 A:HIS119 2.9 6.7 1.0 CE1 A:HIS96 3.0 8.3 1.0 CD2 A:HIS96 3.0 8.6 1.0 CE1 A:HIS94 3.1 9.5 1.0 CG A:HIS119 3.2 5.6 1.0 CB A:HIS119 3.6 6.8 1.0 O A:HOH289 3.7 10.8 1.0 OG1 A:THR199 3.8 7.3 1.0 OE1 A:GLU106 4.0 8.6 1.0 NE2 A:HIS119 4.1 7.6 1.0 CG A:HIS94 4.1 6.9 1.0 ND1 A:HIS96 4.1 7.8 1.0 O A:HOH414 4.1 8.3 0.5 CG A:HIS96 4.2 8.8 1.0 ND1 A:HIS94 4.2 7.8 1.0 O A:HOH414 4.2 10.7 0.5 CD2 A:HIS119 4.2 7.5 1.0 O A:HOH334 4.3 17.9 1.0 CD A:GLU106 4.9 9.3 1.0

D.West, R.Mckenna, A.Robbins, C.Tu, C.Kim, J.Gordon, D.Silverman. Structural Modification of the Hydrophobic Pocket of Human Carbonic Anhydrase II To Be Published.