Atomistry » Zinc » PDB 3sbh-3siq » 3sfy
Atomistry »
  Zinc »
    PDB 3sbh-3siq »
      3sfy »

Zinc in PDB 3sfy: Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Ethylenediamine Inhibitor 2

Protein crystallography data

The structure of Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Ethylenediamine Inhibitor 2, PDB code: 3sfy was solved by M.A.Hast, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.57 / 2.10
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 141.159, 141.159, 129.635, 90.00, 90.00, 90.00
R / Rfree (%) 17.8 / 20.3

Other elements in 3sfy:

The structure of Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Ethylenediamine Inhibitor 2 also contains other interesting chemical elements:

Bromine (Br) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Ethylenediamine Inhibitor 2 (pdb code 3sfy). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Ethylenediamine Inhibitor 2, PDB code: 3sfy:

Zinc binding site 1 out of 1 in 3sfy

Go back to Zinc Binding Sites List in 3sfy
Zinc binding site 1 out of 1 in the Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Ethylenediamine Inhibitor 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Ethylenediamine Inhibitor 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn521

b:28.3
occ:1.00
NAW B:3FY525 2.0 37.2 0.9
NE2 B:HIS410 2.1 23.6 1.0
OD2 B:ASP323 2.1 25.4 1.0
SG B:CYS325 2.3 24.8 1.0
OD1 B:ASP323 2.6 25.5 1.0
CG B:ASP323 2.7 25.9 1.0
CAP B:3FY525 2.8 41.4 0.9
CD2 B:HIS410 2.9 21.8 1.0
CAO B:3FY525 3.1 41.9 0.9
CE1 B:HIS410 3.1 23.5 1.0
CB B:CYS325 3.3 22.7 1.0
CE2 B:TYR409 3.8 27.1 1.0
O B:HOH2742 3.9 31.8 1.0
NBH B:3FY525 4.0 46.5 0.9
CG B:HIS410 4.1 22.9 1.0
CBC B:3FY525 4.1 44.4 0.9
CB B:ASP323 4.1 23.6 1.0
N B:CYS325 4.2 23.1 1.0
ND1 B:HIS410 4.2 21.4 1.0
CB B:ASP400 4.2 26.6 1.0
O B:HOH2092 4.3 15.7 1.0
CA B:CYS325 4.3 23.6 1.0
CG B:ASP400 4.5 28.2 1.0
OH B:TYR409 4.5 25.7 1.0
CA B:ASP400 4.7 26.3 1.0
CZ B:TYR409 4.7 26.3 1.0
CD2 B:TYR409 4.7 24.6 1.0
OD2 B:ASP400 4.8 31.8 1.0
OD1 B:ASP400 4.8 29.7 1.0

Reference:

M.A.Hast, C.B.Nichols, S.M.Armstrong, S.M.Kelly, H.W.Hellinga, J.A.Alspaugh, L.S.Beese. Structures of Cryptococcus Neoformans Protein Farnesyltransferase Reveal Strategies For Developing Inhibitors That Target Fungal Pathogens. J.Biol.Chem. V. 286 35149 2011.
ISSN: ISSN 0021-9258
PubMed: 21816822
DOI: 10.1074/JBC.M111.250506
Page generated: Wed Dec 16 04:50:09 2020

Last articles

Zn in 7M6U
Zn in 7NNG
Zn in 7NEE
Zn in 7NEU
Zn in 7M3K
Zn in 7KWD
Zn in 7KYH
Zn in 7KNG
Zn in 7KY2
Zn in 7KYF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy