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Atomistry » Zinc » PDB 3rj8-3rx7 » 3rqk » |
Zinc in PDB 3rqk: Structure of the Neuronal Nitric Oxide Synthase Heme Domain in Complex with 4-Methyl-6-{[(3R,4R)-4-(2-{[(1R,2S)-2-(3-Methylphenyl) Cyclopropyl]Amino}Ethoxy)Pyrrolidin-3-Yl]Methyl}Pyridin-2-Amine and Its IsomerEnzymatic activity of Structure of the Neuronal Nitric Oxide Synthase Heme Domain in Complex with 4-Methyl-6-{[(3R,4R)-4-(2-{[(1R,2S)-2-(3-Methylphenyl) Cyclopropyl]Amino}Ethoxy)Pyrrolidin-3-Yl]Methyl}Pyridin-2-Amine and Its Isomer
All present enzymatic activity of Structure of the Neuronal Nitric Oxide Synthase Heme Domain in Complex with 4-Methyl-6-{[(3R,4R)-4-(2-{[(1R,2S)-2-(3-Methylphenyl) Cyclopropyl]Amino}Ethoxy)Pyrrolidin-3-Yl]Methyl}Pyridin-2-Amine and Its Isomer:
1.14.13.39; Protein crystallography data
The structure of Structure of the Neuronal Nitric Oxide Synthase Heme Domain in Complex with 4-Methyl-6-{[(3R,4R)-4-(2-{[(1R,2S)-2-(3-Methylphenyl) Cyclopropyl]Amino}Ethoxy)Pyrrolidin-3-Yl]Methyl}Pyridin-2-Amine and Its Isomer, PDB code: 3rqk
was solved by
H.Li,
S.L.Delker,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3rqk:
The structure of Structure of the Neuronal Nitric Oxide Synthase Heme Domain in Complex with 4-Methyl-6-{[(3R,4R)-4-(2-{[(1R,2S)-2-(3-Methylphenyl) Cyclopropyl]Amino}Ethoxy)Pyrrolidin-3-Yl]Methyl}Pyridin-2-Amine and Its Isomer also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of the Neuronal Nitric Oxide Synthase Heme Domain in Complex with 4-Methyl-6-{[(3R,4R)-4-(2-{[(1R,2S)-2-(3-Methylphenyl) Cyclopropyl]Amino}Ethoxy)Pyrrolidin-3-Yl]Methyl}Pyridin-2-Amine and Its Isomer
(pdb code 3rqk). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of the Neuronal Nitric Oxide Synthase Heme Domain in Complex with 4-Methyl-6-{[(3R,4R)-4-(2-{[(1R,2S)-2-(3-Methylphenyl) Cyclopropyl]Amino}Ethoxy)Pyrrolidin-3-Yl]Methyl}Pyridin-2-Amine and Its Isomer, PDB code: 3rqk: Zinc binding site 1 out of 1 in 3rqkGo back to Zinc Binding Sites List in 3rqk
Zinc binding site 1 out
of 1 in the Structure of the Neuronal Nitric Oxide Synthase Heme Domain in Complex with 4-Methyl-6-{[(3R,4R)-4-(2-{[(1R,2S)-2-(3-Methylphenyl) Cyclopropyl]Amino}Ethoxy)Pyrrolidin-3-Yl]Methyl}Pyridin-2-Amine and Its Isomer
Mono view Stereo pair view
Reference:
H.Li,
F.Xue,
J.M.Kraus,
H.Ji,
K.J.Labby,
J.Mataka,
S.L.Delker,
P.Martasek,
L.J.Roman,
T.L.Poulos,
R.B.Silverman.
Cyclopropyl- and Methyl-Containing Inhibitors of Neuronal Nitric Oxide Synthase. Bioorg.Med.Chem. V. 21 1333 2013.
Page generated: Sat Oct 26 15:02:02 2024
ISSN: ISSN 0968-0896 PubMed: 23352768 DOI: 10.1016/J.BMC.2012.12.019 |
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