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Atomistry » Zinc » PDB 3qzc-3rj7 » 3r17 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 3qzc-3rj7 » 3r17 » |
Zinc in PDB 3r17: Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) AcetamideEnzymatic activity of Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide
All present enzymatic activity of Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide:
4.2.1.1; Protein crystallography data
The structure of Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide, PDB code: 3r17
was solved by
S.Biswas,
R.Mckenna,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3r17:
The structure of Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide
(pdb code 3r17). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide, PDB code: 3r17: Zinc binding site 1 out of 1 in 3r17Go back to Zinc Binding Sites List in 3r17
Zinc binding site 1 out
of 1 in the Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide
Mono view Stereo pair view
Reference:
S.Biswas,
M.Aggarwal,
O.Guzel,
A.Scozzafava,
R.Mckenna,
C.T.Supuran.
Conformational Variability of Different Sulfonamide Inhibitors with Thienyl-Acetamido Moieties Attributes to Differential Binding in the Active Site of Cytosolic Human Carbonic Anhydrase Isoforms. Bioorg.Med.Chem. V. 19 3732 2011.
Page generated: Wed Dec 16 04:46:40 2020
ISSN: ISSN 0968-0896 PubMed: 21620713 DOI: 10.1016/J.BMC.2011.05.006 |
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