Zinc in PDB 3qmh: Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Tcga) By the Cxxc Domain of CFP1

The structure of Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Tcga) By the Cxxc Domain of CFP1, PDB code: 3qmh was solved by C.Xu, C.Bian, F.Mackenzie, C.Bountra, J.Weigelt, C.H.Arrowsmith, A.M.Edwards, J.Min, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.98 / 2.50
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	30.458, 73.956, 124.062, 90.00, 90.00, 90.00
R / Rfree (%)	20.6 / 23.1

The binding sites of Zinc atom in the Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Tcga) By the Cxxc Domain of CFP1 (pdb code 3qmh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Tcga) By the Cxxc Domain of CFP1, PDB code: 3qmh:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Tcga) By the Cxxc Domain of CFP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Tcga) By the Cxxc Domain of CFP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn300 b:46.2 occ:1.00 SG A:CYS172 2.1 52.8 1.0 SG A:CYS208 2.2 51.0 1.0 SG A:CYS169 2.3 54.3 1.0 SG A:CYS175 2.4 47.1 1.0 CB A:CYS208 3.2 46.6 1.0 CB A:CYS172 3.3 51.6 1.0 CB A:CYS169 3.4 54.3 1.0 CB A:CYS175 3.5 49.7 1.0 N A:CYS169 3.5 50.8 1.0 CA A:CYS208 3.6 44.6 1.0 N A:CYS172 3.7 54.6 1.0 N A:GLY170 3.8 53.2 1.0 N A:GLN209 3.9 48.4 1.0 CA A:CYS169 3.9 53.3 1.0 CA A:CYS172 4.1 53.6 1.0 C A:CYS208 4.2 46.5 1.0 N A:GLU171 4.2 56.4 1.0 C A:CYS169 4.3 54.2 1.0 N A:CYS175 4.3 46.1 1.0 CA A:CYS175 4.4 47.2 1.0 N A:LEU210 4.6 54.7 1.0 C A:MET168 4.6 50.4 1.0 C A:GLU171 4.8 57.4 1.0 C A:CYS172 4.8 52.0 1.0 CA A:GLY170 4.8 55.1 1.0 CA A:MET168 4.9 47.2 1.0 CB A:LEU210 4.9 58.0 1.0 N A:CYS208 5.0 41.5 1.0

Zinc binding site 2 out of 2 in the Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Tcga) By the Cxxc Domain of CFP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Tcga) By the Cxxc Domain of CFP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:41.2 occ:1.00 SG A:CYS181 2.1 45.6 1.0 SG A:CYS203 2.2 33.3 1.0 SG A:CYS184 2.2 45.1 1.0 SG A:CYS187 2.2 39.2 1.0 CB A:CYS187 3.2 42.2 1.0 CB A:CYS203 3.2 29.1 1.0 CB A:CYS184 3.5 45.3 1.0 CB A:CYS181 3.5 43.9 1.0 CA A:CYS203 3.5 29.8 1.0 N A:CYS181 3.6 42.3 1.0 N A:GLY182 3.8 43.0 1.0 N A:CYS184 3.8 47.3 1.0 N A:ARG204 3.8 32.1 1.0 CA A:CYS181 4.0 43.5 1.0 C A:CYS203 4.1 31.2 1.0 N A:CYS187 4.2 42.1 1.0 CA A:CYS184 4.2 48.1 1.0 CA A:CYS187 4.2 42.0 1.0 N A:HIS183 4.3 47.8 1.0 C A:CYS181 4.3 44.8 1.0 C A:ASP180 4.6 42.0 1.0 N A:CYS203 4.7 29.3 1.0 CA A:GLY182 4.8 42.9 1.0 C A:CYS184 4.9 49.4 1.0 O A:CYS184 4.9 49.9 1.0 N A:LEU205 4.9 36.1 1.0 CA A:ASP180 4.9 42.3 1.0 C A:HIS183 4.9 50.9 1.0 CB A:ASP180 5.0 42.7 1.0

C.Xu, C.Bian, R.Lam, A.Dong, J.Min. The Structural Basis For Selective Binding of Non-Methylated Cpg Islands By the CFP1 Cxxc Domain. Nat Commun V. 2 227 2011.
ISSN: ESSN 2041-1723
PubMed: 21407193
DOI: 10.1038/NCOMMS1237