Zinc in PDB 3qmg: Structural Basis of Selective Binding of Non-Methylated Cpg Islands By the Cxxc Domain of CFP1

The structure of Structural Basis of Selective Binding of Non-Methylated Cpg Islands By the Cxxc Domain of CFP1, PDB code: 3qmg was solved by C.Xu, C.Bian, F.Mackenzie, C.Bountra, J.Weigelt, C.H.Arrowsmith, A.M.Edwards, J.Min, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	62.88 / 2.30
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	30.436, 74.910, 125.755, 90.00, 90.00, 90.00
R / Rfree (%)	21.6 / 27.9

The binding sites of Zinc atom in the Structural Basis of Selective Binding of Non-Methylated Cpg Islands By the Cxxc Domain of CFP1 (pdb code 3qmg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structural Basis of Selective Binding of Non-Methylated Cpg Islands By the Cxxc Domain of CFP1, PDB code: 3qmg:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structural Basis of Selective Binding of Non-Methylated Cpg Islands By the Cxxc Domain of CFP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Basis of Selective Binding of Non-Methylated Cpg Islands By the Cxxc Domain of CFP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn300 b:7.0 occ:1.00 SG A:CYS208 2.2 8.3 1.0 SG A:CYS172 2.2 10.2 1.0 SG A:CYS169 2.3 8.9 1.0 SG A:CYS175 2.4 8.1 1.0 CB A:CYS208 3.2 8.1 1.0 CB A:CYS172 3.3 5.5 1.0 CB A:CYS169 3.4 10.9 1.0 CB A:CYS175 3.4 11.4 1.0 N A:CYS169 3.5 11.9 1.0 CA A:CYS208 3.6 7.0 1.0 N A:CYS172 3.8 8.4 1.0 N A:GLY170 3.8 10.3 1.0 CA A:CYS169 3.9 10.5 1.0 CA A:CYS172 4.1 7.2 1.0 N A:GLN209 4.1 8.2 1.0 N A:CYS175 4.2 12.1 1.0 C A:CYS169 4.3 11.3 1.0 C A:CYS208 4.3 7.0 1.0 N A:GLU171 4.3 10.6 1.0 CA A:CYS175 4.4 11.2 1.0 C A:MET168 4.6 12.7 1.0 N A:LEU210 4.8 11.8 1.0 C A:CYS172 4.8 8.3 1.0 CA A:GLY170 4.8 10.3 1.0 O A:CYS172 4.8 7.3 1.0 CA A:MET168 4.9 12.8 1.0 N A:CYS208 4.9 7.4 1.0 C A:GLU171 4.9 8.5 1.0

Zinc binding site 2 out of 2 in the Structural Basis of Selective Binding of Non-Methylated Cpg Islands By the Cxxc Domain of CFP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structural Basis of Selective Binding of Non-Methylated Cpg Islands By the Cxxc Domain of CFP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:4.6 occ:1.00 SG A:CYS203 2.2 2.0 1.0 SG A:CYS187 2.3 6.0 1.0 SG A:CYS181 2.3 9.5 1.0 SG A:CYS184 2.3 6.0 1.0 CB A:CYS203 3.1 2.0 1.0 CB A:CYS187 3.3 4.9 1.0 CB A:CYS181 3.4 11.9 1.0 CB A:CYS184 3.5 6.9 1.0 N A:CYS181 3.5 13.2 1.0 CA A:CYS203 3.5 3.0 1.0 N A:ARG204 3.8 3.4 1.0 N A:GLY182 3.8 8.6 1.0 CA A:CYS181 3.9 11.5 1.0 N A:CYS184 3.9 10.1 1.0 C A:CYS203 4.1 2.0 1.0 N A:CYS187 4.2 5.7 1.0 C A:CYS181 4.2 8.8 1.0 CA A:CYS184 4.3 7.2 1.0 CA A:CYS187 4.3 5.3 1.0 N A:HIS183 4.3 8.4 1.0 C A:ASP180 4.6 12.3 1.0 N A:LEU205 4.7 6.0 1.0 N A:CYS203 4.8 3.3 1.0 CA A:ARG204 4.9 7.0 1.0 CA A:GLY182 4.9 5.1 1.0 C A:CYS184 4.9 8.1 1.0 O A:CYS184 4.9 10.0 1.0 CB A:ARG204 4.9 7.2 1.0 CA A:ASP180 5.0 12.4 1.0

C.Xu, C.Bian, R.Lam, A.Dong, J.Min. The Structural Basis For Selective Binding of Non-Methylated Cpg Islands By the CFP1 Cxxc Domain. Nat Commun V. 2 227 2011.
ISSN: ESSN 2041-1723
PubMed: 21407193
DOI: 10.1038/NCOMMS1237