Zinc in PDB 3pfs: Pwwp Domain of Human Bromodomain and Phd Finger-Containing Protein 3

The structure of Pwwp Domain of Human Bromodomain and Phd Finger-Containing Protein 3, PDB code: 3pfs was solved by R.Lam, H.Zeng, J.Kania, C.Bountra, J.Weigelt, C.H.Arrowsmith, A.M.Edwards, J.Min, H.Wu, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.63 / 1.90
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	68.412, 134.522, 30.226, 90.00, 90.00, 90.00
R / Rfree (%)	21.1 / 25.9

The binding sites of Zinc atom in the Pwwp Domain of Human Bromodomain and Phd Finger-Containing Protein 3 (pdb code 3pfs). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Pwwp Domain of Human Bromodomain and Phd Finger-Containing Protein 3, PDB code: 3pfs:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Pwwp Domain of Human Bromodomain and Phd Finger-Containing Protein 3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Pwwp Domain of Human Bromodomain and Phd Finger-Containing Protein 3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1200 b:20.5 occ:1.00 SG A:CYS1084 2.2 17.7 1.0 CB A:CYS1084 3.2 16.7 1.0 OE1 A:GLN1146 3.7 23.1 1.0 CE2 A:PHE1138 3.7 11.0 1.0 CG A:GLN1146 4.0 17.9 1.0 CD A:GLN1146 4.0 21.3 1.0 CZ A:PHE1138 4.0 10.9 1.0 CB A:GLN1146 4.4 15.5 1.0 CA A:CYS1084 4.6 16.5 1.0 CD2 A:PHE1138 4.6 10.9 1.0 O A:HOH9 4.9 13.8 1.0 NE2 A:GLN1146 4.9 24.2 1.0 CD2 A:TYR1087 4.9 15.9 1.0 CE2 A:TYR1087 4.9 17.0 1.0

Zinc binding site 2 out of 2 in the Pwwp Domain of Human Bromodomain and Phd Finger-Containing Protein 3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Pwwp Domain of Human Bromodomain and Phd Finger-Containing Protein 3 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1200 b:25.5 occ:1.00 SG B:CYS1084 2.1 23.0 1.0 CB B:CYS1084 3.2 21.4 1.0 CE2 B:PHE1138 3.7 10.7 1.0 NE2 B:GLN1146 3.8 20.1 1.0 CG B:GLN1146 4.0 18.1 1.0 CZ B:PHE1138 4.0 10.5 1.0 CD B:GLN1146 4.2 20.9 1.0 CB B:GLN1146 4.2 16.1 1.0 CA B:CYS1084 4.7 20.7 1.0 CD2 B:PHE1138 4.7 10.7 1.0 O B:HOH3 4.9 16.6 1.0

H.Wu, H.Zeng, R.Lam, W.Tempel, M.F.Amaya, C.Xu, L.Dombrovski, W.Qiu, Y.Wang, J.Min. Structural and Histone Binding Ability Characterizations of Human Pwwp Domains. Plos One V. 6 18919 2011.
ISSN: ESSN 1932-6203
PubMed: 21720545
DOI: 10.1371/JOURNAL.PONE.0018919