Zinc in PDB 3od4: Crystal Structure of Factor Inhibiting Hif-1 Alpha Complexed with Inhibitor

All present enzymatic activity of Crystal Structure of Factor Inhibiting Hif-1 Alpha Complexed with Inhibitor:
1.14.11.16;

The structure of Crystal Structure of Factor Inhibiting Hif-1 Alpha Complexed with Inhibitor, PDB code: 3od4 was solved by O.N.F.King, R.Bashford-Rogers, D.J.Maloney, A.Jadhav, T.D.Heightman, A.Simeonov, I.J.Clifton, M.A.Mcdonough, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.64 / 2.20
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	86.400, 86.400, 147.200, 90.00, 90.00, 90.00
R / Rfree (%)	17.6 / 21.2

The binding sites of Zinc atom in the Crystal Structure of Factor Inhibiting Hif-1 Alpha Complexed with Inhibitor (pdb code 3od4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Factor Inhibiting Hif-1 Alpha Complexed with Inhibitor, PDB code: 3od4:

Zinc binding site 1 out of 1 in the Crystal Structure of Factor Inhibiting Hif-1 Alpha Complexed with Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Factor Inhibiting Hif-1 Alpha Complexed with Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1350 b:48.5 occ:1.00 OD2 A:ASP201 2.0 31.2 1.0 OAC A:8XQ350 2.2 46.7 1.0 NE2 A:HIS199 2.2 44.7 1.0 NAI A:8XQ350 2.2 50.7 1.0 O A:HOH490 2.3 55.5 1.0 CG A:ASP201 2.8 37.9 1.0 CAK A:8XQ350 2.8 39.9 1.0 CAN A:8XQ350 2.9 43.1 1.0 OD1 A:ASP201 3.0 41.3 1.0 CD2 A:HIS199 3.1 41.2 1.0 CE1 A:HIS199 3.2 41.5 1.0 CAE A:8XQ350 3.2 46.4 1.0 NE2 A:HIS279 3.5 37.0 1.0 CZ2 A:TRP296 4.1 57.6 1.0 CAF A:8XQ350 4.2 43.9 1.0 CAM A:8XQ350 4.2 40.6 1.0 CE1 A:HIS279 4.2 33.6 1.0 ND1 A:HIS199 4.3 39.2 1.0 CG A:HIS199 4.3 42.6 1.0 CB A:ASP201 4.3 35.2 1.0 O A:HOH389 4.4 45.3 1.0 CAD A:8XQ350 4.5 45.1 1.0 CD2 A:HIS279 4.5 37.8 1.0 CH2 A:TRP296 4.8 62.7 1.0 CAH A:8XQ350 4.9 40.5 1.0 O2 A:GOL355 4.9 85.3 1.0

O.N.F.King, R.Bashford-Rogers, D.J.Maloney, A.Jadhav, T.D.Heightman, A.Simeonov, I.J.Clifton, M.A.Mcdonough, C.J.Schofield. Crystal Structure of Factor Inhibiting Hif-1 Alpha Complexed with Inhibitor To Be Published.