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Zinc in PDB 3o56: Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with A 5- Heterocycle Pyrazolopyridine Inhibitor

Enzymatic activity of Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with A 5- Heterocycle Pyrazolopyridine Inhibitor

All present enzymatic activity of Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with A 5- Heterocycle Pyrazolopyridine Inhibitor:
3.1.4.17;

Protein crystallography data

The structure of Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with A 5- Heterocycle Pyrazolopyridine Inhibitor, PDB code: 3o56 was solved by D.O.Somers, M.Neu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.42
Space group I 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 88.531, 94.592, 105.089, 90.00, 90.00, 90.00
R / Rfree (%) 19.6 / 26

Other elements in 3o56:

The structure of Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with A 5- Heterocycle Pyrazolopyridine Inhibitor also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Arsenic (As) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with A 5- Heterocycle Pyrazolopyridine Inhibitor (pdb code 3o56). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with A 5- Heterocycle Pyrazolopyridine Inhibitor, PDB code: 3o56:

Zinc binding site 1 out of 1 in 3o56

Go back to Zinc Binding Sites List in 3o56
Zinc binding site 1 out of 1 in the Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with A 5- Heterocycle Pyrazolopyridine Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with A 5- Heterocycle Pyrazolopyridine Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1

b:35.6
occ:1.00
 OD2 A:ASP275 1.9 22.8 1.0
OD1 A:ASP392 2.0 32.6 1.0
O A:HOH51 2.1 32.9 1.0
NE2 A:HIS238 2.1 13.3 1.0
NE2 A:HIS274 2.3 22.0 1.0
O A:HOH81 2.8 33.4 1.0
CG A:ASP392 2.9 36.2 1.0
CD2 A:HIS238 3.0 17.3 1.0
CG A:ASP275 3.1 27.1 1.0
CE1 A:HIS274 3.1 21.3 1.0
CE1 A:HIS238 3.2 19.1 1.0
CD2 A:HIS274 3.2 29.3 1.0
OD2 A:ASP392 3.3 31.7 1.0
OD1 A:ASP275 3.6 24.0 1.0
NE2 A:HIS234 4.1 43.4 1.0
MG A:MG504 4.1 44.5 1.0
CD2 A:HIS234 4.1 41.1 1.0
CG A:HIS238 4.2 9.8 1.0
ND1 A:HIS274 4.2 42.0 1.0
O A:HOH80 4.2 42.9 1.0
ND1 A:HIS238 4.3 13.7 1.0
CB A:ASP275 4.3 25.3 1.0
CG A:HIS274 4.3 36.8 1.0
O A:HOH53 4.3 58.8 1.0
CB A:ASP392 4.3 33.8 1.0
CG2 A:VAL242 4.6 41.1 1.0
O A:HOH52 4.7 32.8 1.0
CA A:ASP392 4.9 37.2 1.0

Reference:

C.J.Mitchell, S.P.Ballantine, D.M.Coe, C.M.Cook, C.J.Delves, M.D.Dowle, C.D.Edlin, J.N.Hamblin, S.Holman, M.R.Johnson, P.S.Jones, S.E.Keeling, M.Kranz, M.Lindvall, F.S.Lucas, M.Neu, Y.E.Solanke, D.O.Somers, N.A.Trivedi, J.O.Wiseman. Pyrazolopyridines As Potent PDE4B Inhibitors: 5-Heterocycle Sar. Bioorg.Med.Chem.Lett. V. 20 5803 2010.
ISSN: ISSN 0960-894X
PubMed: 20732811
DOI: 10.1016/J.BMCL.2010.07.136
Page generated: Sat Oct 26 10:45:39 2024

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