Zinc in PDB 3o35: Crystal Structure of TRIM24 Phd-Bromo Complexed with H3(23-31)K27AC Peptide

The structure of Crystal Structure of TRIM24 Phd-Bromo Complexed with H3(23-31)K27AC Peptide, PDB code: 3o35 was solved by Z.Wang, D.J.Patel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.76
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	89.632, 36.498, 128.824, 90.00, 109.99, 90.00
R / Rfree (%)	20.6 / 22.5

The binding sites of Zinc atom in the Crystal Structure of TRIM24 Phd-Bromo Complexed with H3(23-31)K27AC Peptide (pdb code 3o35). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of TRIM24 Phd-Bromo Complexed with H3(23-31)K27AC Peptide, PDB code: 3o35:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Crystal Structure of TRIM24 Phd-Bromo Complexed with H3(23-31)K27AC Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of TRIM24 Phd-Bromo Complexed with H3(23-31)K27AC Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:25.6 occ:1.00 SG A:CYS852 2.3 22.0 1.0 ND1 A:HIS849 2.3 32.9 1.0 SG A:CYS832 2.4 20.4 1.0 SG A:CYS829 2.4 19.6 1.0 CB A:CYS829 3.0 21.2 1.0 CB A:CYS852 3.2 21.6 1.0 CE1 A:HIS849 3.2 23.4 1.0 CG A:HIS849 3.2 26.1 1.0 CB A:CYS832 3.4 23.8 1.0 CB A:HIS849 3.5 25.5 1.0 N A:CYS832 3.8 23.4 1.0 N A:HIS849 4.1 20.3 1.0 CA A:CYS832 4.2 23.0 1.0 NE2 A:HIS849 4.3 27.6 1.0 CD2 A:HIS849 4.4 30.6 1.0 CA A:HIS849 4.5 20.3 1.0 CA A:CYS829 4.5 22.7 1.0 CB A:VAL831 4.6 18.0 1.0 CA A:CYS852 4.6 18.6 1.0 C A:VAL831 4.9 22.4 1.0 C A:CYS832 5.0 23.1 1.0 O A:HOH160 5.0 34.6 1.0 O A:HOH216 5.0 29.8 1.0

Zinc binding site 2 out of 4 in the Crystal Structure of TRIM24 Phd-Bromo Complexed with H3(23-31)K27AC Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of TRIM24 Phd-Bromo Complexed with H3(23-31)K27AC Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2 b:20.6 occ:1.00 SG A:CYS870 2.3 24.2 1.0 SG A:CYS841 2.4 23.1 1.0 SG A:CYS844 2.4 23.8 1.0 SG A:CYS867 2.4 18.4 1.0 CB A:CYS841 3.3 25.0 1.0 CB A:CYS844 3.3 28.4 1.0 CB A:CYS870 3.3 18.3 1.0 CB A:CYS867 3.5 19.9 1.0 N A:CYS844 3.8 31.1 1.0 N A:CYS870 4.0 14.2 1.0 N A:CYS867 4.1 18.1 1.0 CA A:CYS844 4.1 30.2 1.0 CA A:CYS867 4.3 16.4 1.0 CA A:CYS870 4.3 17.9 1.0 C A:LYS843 4.5 25.1 1.0 O A:CYS867 4.6 15.1 1.0 CB A:PHE869 4.6 16.8 1.0 C A:CYS867 4.7 16.8 1.0 C A:CYS844 4.7 29.9 1.0 CA A:CYS841 4.7 26.8 1.0 N A:LYS843 4.8 26.0 1.0 O A:CYS844 4.8 28.4 1.0 CB A:LYS843 4.9 26.3 1.0 CA A:LYS843 4.9 25.5 1.0 C A:PHE869 4.9 18.3 1.0

Zinc binding site 3 out of 4 in the Crystal Structure of TRIM24 Phd-Bromo Complexed with H3(23-31)K27AC Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of TRIM24 Phd-Bromo Complexed with H3(23-31)K27AC Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1 b:32.8 occ:1.00 ND1 B:HIS849 2.2 29.2 1.0 SG B:CYS852 2.4 24.8 1.0 SG B:CYS832 2.4 25.8 1.0 SG B:CYS829 2.4 24.3 1.0 CB B:CYS829 3.0 26.1 1.0 CE1 B:HIS849 3.1 23.0 1.0 CG B:HIS849 3.2 30.0 1.0 CB B:CYS852 3.2 24.1 1.0 CB B:CYS832 3.4 29.8 1.0 CB B:HIS849 3.5 29.0 1.0 N B:CYS832 3.8 26.7 1.0 N B:HIS849 4.1 25.9 1.0 CA B:CYS832 4.2 27.9 1.0 NE2 B:HIS849 4.3 27.9 1.0 CD2 B:HIS849 4.3 28.9 1.0 CA B:HIS849 4.5 26.0 1.0 CA B:CYS829 4.5 28.4 1.0 CB B:VAL831 4.6 28.0 1.0 CA B:CYS852 4.7 20.8 1.0 C B:VAL831 4.9 28.6 1.0 C B:CYS832 4.9 30.0 1.0

Zinc binding site 4 out of 4 in the Crystal Structure of TRIM24 Phd-Bromo Complexed with H3(23-31)K27AC Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of TRIM24 Phd-Bromo Complexed with H3(23-31)K27AC Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2 b:32.8 occ:1.00 SG B:CYS841 2.4 35.6 1.0 SG B:CYS870 2.4 33.3 1.0 SG B:CYS867 2.4 24.1 1.0 SG B:CYS844 2.4 35.1 1.0 CB B:CYS844 3.2 39.9 1.0 CB B:CYS841 3.3 38.8 1.0 CB B:CYS870 3.4 28.1 1.0 CB B:CYS867 3.6 24.1 1.0 N B:CYS844 3.8 49.3 1.0 N B:CYS867 4.0 24.4 1.0 N B:CYS870 4.0 24.7 1.0 CA B:CYS844 4.1 47.9 1.0 CA B:CYS867 4.3 21.9 1.0 CA B:CYS870 4.4 25.8 1.0 C B:LYS843 4.4 46.8 1.0 O B:CYS867 4.7 20.6 1.0 CB B:LYS843 4.7 48.3 1.0 CB B:PHE869 4.7 20.0 1.0 C B:CYS867 4.7 22.0 1.0 C B:CYS844 4.7 47.9 1.0 CA B:CYS841 4.8 41.7 1.0 N B:LYS843 4.8 48.0 1.0 CA B:LYS843 4.8 46.5 1.0 O B:CYS844 4.9 48.5 1.0 C B:PHE869 5.0 23.5 1.0

W.W.Tsai, Z.Wang, T.T.Yiu, K.C.Akdemir, W.Xia, S.Winter, C.Y.Tsai, X.Shi, D.Schwarzer, W.Plunkett, B.Aronow, O.Gozani, W.Fischle, M.C.Hung, D.J.Patel, M.C.Barton. TRIM24 Links A Non-Canonical Histone Signature to Breast Cancer. Nature V. 468 927 2010.
ISSN: ISSN 0028-0836
PubMed: 21164480
DOI: 10.1038/NATURE09542