Zinc in PDB 3o33: Crystal Structure of TRIM24 Phd-Bromo in the Free State

The structure of Crystal Structure of TRIM24 Phd-Bromo in the Free State, PDB code: 3o33 was solved by Z.Wang, D.J.Patel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.69 / 2.00
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	36.482, 48.498, 122.729, 86.45, 81.46, 67.84
R / Rfree (%)	22.1 / 24.4

The binding sites of Zinc atom in the Crystal Structure of TRIM24 Phd-Bromo in the Free State (pdb code 3o33). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the Crystal Structure of TRIM24 Phd-Bromo in the Free State, PDB code: 3o33:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Zinc binding site 1 out of 8 in the Crystal Structure of TRIM24 Phd-Bromo in the Free State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of TRIM24 Phd-Bromo in the Free State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:30.6 occ:1.00 ND1 A:HIS849 2.2 34.3 1.0 SG A:CYS832 2.2 34.2 1.0 SG A:CYS852 2.3 33.5 1.0 SG A:CYS829 2.3 28.4 1.0 CB A:CYS829 3.1 30.3 1.0 CE1 A:HIS849 3.1 32.3 1.0 CG A:HIS849 3.1 33.4 1.0 CB A:CYS852 3.2 32.7 1.0 CB A:CYS832 3.4 31.9 1.0 CB A:HIS849 3.4 31.1 1.0 N A:CYS832 3.7 31.4 1.0 CA A:CYS832 4.1 32.5 1.0 N A:HIS849 4.2 29.9 1.0 NE2 A:HIS849 4.2 31.9 1.0 CD2 A:HIS849 4.3 31.4 1.0 CA A:HIS849 4.4 30.1 1.0 CA A:CYS829 4.6 33.9 1.0 CB A:VAL831 4.6 34.3 1.0 CA A:CYS852 4.6 26.7 1.0 C A:VAL831 4.8 33.3 1.0 N A:GLN833 4.9 31.6 1.0 C A:CYS832 4.9 33.5 1.0

Zinc binding site 2 out of 8 in the Crystal Structure of TRIM24 Phd-Bromo in the Free State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of TRIM24 Phd-Bromo in the Free State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2 b:41.8 occ:1.00 SG A:CYS870 2.1 43.5 1.0 SG A:CYS841 2.2 38.0 1.0 SG A:CYS844 2.5 40.2 1.0 SG A:CYS867 2.5 36.6 1.0 CB A:CYS844 3.1 39.6 1.0 CB A:CYS870 3.2 39.1 1.0 CB A:CYS841 3.3 43.5 1.0 CB A:CYS867 3.6 35.1 1.0 N A:CYS844 3.7 51.7 1.0 CA A:CYS844 4.0 50.1 1.0 N A:CYS870 4.0 33.1 1.0 N A:CYS867 4.1 34.9 1.0 CA A:CYS870 4.2 35.3 1.0 CA A:CYS867 4.3 32.4 1.0 C A:LYS843 4.5 58.0 1.0 CB A:LYS843 4.6 67.2 1.0 C A:CYS844 4.6 49.6 1.0 CA A:CYS841 4.7 46.0 1.0 CB A:PHE869 4.7 28.3 1.0 O A:CYS867 4.8 29.8 1.0 O A:CYS844 4.8 49.9 1.0 C A:CYS867 4.8 30.5 1.0 N A:LYS843 4.9 58.6 1.0 CA A:LYS843 4.9 58.5 1.0 C A:PHE869 5.0 31.1 1.0

Zinc binding site 3 out of 8 in the Crystal Structure of TRIM24 Phd-Bromo in the Free State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of TRIM24 Phd-Bromo in the Free State within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1 b:25.9 occ:1.00 ND1 B:HIS849 2.1 35.2 1.0 SG B:CYS829 2.2 22.9 1.0 SG B:CYS852 2.3 25.5 1.0 SG B:CYS832 2.4 26.0 1.0 CB B:CYS829 3.0 22.5 1.0 CE1 B:HIS849 3.1 27.4 1.0 CG B:HIS849 3.2 30.9 1.0 CB B:CYS852 3.2 23.4 1.0 CB B:CYS832 3.4 27.3 1.0 CB B:HIS849 3.5 30.1 1.0 N B:CYS832 3.7 27.4 1.0 N B:HIS849 4.1 27.3 1.0 CA B:CYS832 4.1 27.5 1.0 NE2 B:HIS849 4.2 32.1 1.0 CD2 B:HIS849 4.3 37.6 1.0 CA B:HIS849 4.4 26.1 1.0 CA B:CYS829 4.5 22.9 1.0 CB B:VAL831 4.6 25.0 1.0 CA B:CYS852 4.6 22.2 1.0 C B:VAL831 4.8 31.1 1.0 C B:CYS832 4.9 26.7 1.0

Zinc binding site 4 out of 8 in the Crystal Structure of TRIM24 Phd-Bromo in the Free State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of TRIM24 Phd-Bromo in the Free State within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2 b:26.9 occ:1.00 SG B:CYS870 2.1 28.4 1.0 SG B:CYS841 2.2 26.7 1.0 SG B:CYS844 2.3 30.4 1.0 SG B:CYS867 2.4 20.9 1.0 CB B:CYS844 3.2 31.7 1.0 CB B:CYS841 3.2 25.7 1.0 CB B:CYS870 3.3 19.1 1.0 CB B:CYS867 3.5 20.6 1.0 N B:CYS844 3.8 34.7 1.0 N B:CYS870 4.1 20.7 1.0 CA B:CYS844 4.1 33.3 1.0 N B:CYS867 4.1 24.2 1.0 CA B:CYS867 4.3 21.4 1.0 CA B:CYS870 4.3 24.9 1.0 C B:LYS843 4.5 33.0 1.0 CB B:PHE869 4.6 20.2 1.0 CA B:CYS841 4.7 34.2 1.0 C B:CYS844 4.7 32.2 1.0 O B:CYS844 4.7 31.7 1.0 O B:CYS867 4.7 19.2 1.0 C B:CYS867 4.8 18.5 1.0 N B:LYS843 4.8 31.2 1.0 CB B:LYS843 4.9 35.1 1.0 CA B:LYS843 4.9 32.7 1.0 C B:PHE869 5.0 24.9 1.0

Zinc binding site 5 out of 8 in the Crystal Structure of TRIM24 Phd-Bromo in the Free State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Crystal Structure of TRIM24 Phd-Bromo in the Free State within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1 b:26.5 occ:1.00 SG C:CYS870 2.2 27.9 1.0 SG C:CYS841 2.3 27.4 1.0 SG C:CYS844 2.4 29.7 1.0 SG C:CYS867 2.4 22.6 1.0 CB C:CYS841 3.2 24.6 1.0 CB C:CYS844 3.2 29.2 1.0 CB C:CYS870 3.3 17.7 1.0 CB C:CYS867 3.5 22.0 1.0 N C:CYS844 3.8 33.4 1.0 N C:CYS867 4.1 23.5 1.0 N C:CYS870 4.1 18.5 1.0 CA C:CYS844 4.1 32.4 1.0 CA C:CYS867 4.3 21.4 1.0 CA C:CYS870 4.4 22.4 1.0 C C:LYS843 4.6 33.3 1.0 CA C:CYS841 4.7 32.3 1.0 CB C:PHE869 4.7 20.6 1.0 O C:CYS867 4.7 17.8 1.0 C C:CYS844 4.7 31.2 1.0 C C:CYS867 4.7 18.3 1.0 CB C:LYS843 4.9 37.7 1.0 O C:CYS844 4.9 31.4 1.0 N C:LYS843 4.9 32.7 1.0 CA C:LYS843 5.0 32.9 1.0

Zinc binding site 6 out of 8 in the Crystal Structure of TRIM24 Phd-Bromo in the Free State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Crystal Structure of TRIM24 Phd-Bromo in the Free State within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn2 b:25.3 occ:1.00 ND1 C:HIS849 2.1 37.0 1.0 SG C:CYS829 2.2 21.6 1.0 SG C:CYS852 2.3 24.8 1.0 SG C:CYS832 2.3 26.1 1.0 CB C:CYS829 3.0 20.9 1.0 CE1 C:HIS849 3.0 26.9 1.0 CG C:HIS849 3.1 28.3 1.0 CB C:CYS852 3.2 22.0 1.0 CB C:CYS832 3.4 25.1 1.0 CB C:HIS849 3.4 25.1 1.0 N C:CYS832 3.8 23.7 1.0 N C:HIS849 4.0 27.2 1.0 NE2 C:HIS849 4.1 33.8 1.0 CA C:CYS832 4.2 23.7 1.0 CD2 C:HIS849 4.2 36.3 1.0 CA C:HIS849 4.4 27.4 1.0 CA C:CYS829 4.4 23.6 1.0 CB C:VAL831 4.6 23.9 1.0 CA C:CYS852 4.6 22.1 1.0 C C:VAL831 4.9 24.0 1.0 O C:ASN834 4.9 28.0 1.0 C C:CYS832 4.9 23.6 1.0

Zinc binding site 7 out of 8 in the Crystal Structure of TRIM24 Phd-Bromo in the Free State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Crystal Structure of TRIM24 Phd-Bromo in the Free State within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1 b:32.0 occ:1.00 ND1 D:HIS849 2.0 36.9 1.0 SG D:CYS832 2.2 31.5 1.0 SG D:CYS852 2.3 32.7 1.0 SG D:CYS829 2.4 26.4 1.0 CE1 D:HIS849 2.9 32.3 1.0 CB D:CYS829 3.1 26.8 1.0 CG D:HIS849 3.1 33.5 1.0 CB D:CYS852 3.2 29.6 1.0 CB D:CYS832 3.4 34.0 1.0 CB D:HIS849 3.5 32.8 1.0 N D:CYS832 3.7 29.6 1.0 NE2 D:HIS849 4.1 35.5 1.0 CA D:CYS832 4.1 29.6 1.0 CD2 D:HIS849 4.2 35.4 1.0 N D:HIS849 4.2 33.0 1.0 CA D:HIS849 4.5 31.6 1.0 CA D:CYS829 4.6 34.0 1.0 CA D:CYS852 4.7 26.1 1.0 CB D:VAL831 4.7 31.9 1.0 C D:CYS832 4.8 31.4 1.0 C D:VAL831 4.8 32.8 1.0 N D:GLN833 4.9 36.9 1.0

Zinc binding site 8 out of 8 in the Crystal Structure of TRIM24 Phd-Bromo in the Free State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Crystal Structure of TRIM24 Phd-Bromo in the Free State within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn2 b:40.1 occ:1.00 SG D:CYS870 2.1 40.0 1.0 SG D:CYS841 2.1 39.3 1.0 SG D:CYS844 2.4 40.8 1.0 SG D:CYS867 2.5 34.2 1.0 CB D:CYS841 3.2 39.3 1.0 CB D:CYS844 3.2 39.5 1.0 CB D:CYS870 3.2 35.3 1.0 CB D:CYS867 3.5 34.7 1.0 N D:CYS844 3.7 48.9 1.0 CA D:CYS844 4.0 47.8 1.0 N D:CYS870 4.0 34.9 1.0 N D:CYS867 4.1 35.0 1.0 CA D:CYS870 4.3 38.5 1.0 CA D:CYS867 4.3 31.7 1.0 C D:LYS843 4.5 45.5 1.0 CB D:LYS843 4.6 62.8 1.0 CA D:CYS841 4.6 47.4 1.0 CB D:PHE869 4.7 30.8 1.0 C D:CYS844 4.7 47.7 1.0 C D:CYS867 4.8 29.7 1.0 O D:CYS867 4.8 29.9 1.0 N D:LYS843 4.8 45.5 1.0 O D:CYS844 4.8 47.6 1.0 CA D:LYS843 4.9 45.5 1.0 C D:PHE869 5.0 31.9 1.0

W.W.Tsai, Z.Wang, T.T.Yiu, K.C.Akdemir, W.Xia, S.Winter, C.Y.Tsai, X.Shi, D.Schwarzer, W.Plunkett, B.Aronow, O.Gozani, W.Fischle, M.C.Hung, D.J.Patel, M.C.Barton. TRIM24 Links A Non-Canonical Histone Signature to Breast Cancer. Nature V. 468 927 2010.
ISSN: ISSN 0028-0836
PubMed: 21164480
DOI: 10.1038/NATURE09542