Atomistry » Zinc » PDB 3avr-3b6n » 3n5r
Atomistry »
  Zinc »
    PDB 3avr-3b6n »
      3n5r »

Zinc in PDB 3n5r: Structure of Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4-(3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)Phenethyl)-6- Methylpyridin-2-Amine

Enzymatic activity of Structure of Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4-(3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)Phenethyl)-6- Methylpyridin-2-Amine

All present enzymatic activity of Structure of Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4-(3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)Phenethyl)-6- Methylpyridin-2-Amine:
1.14.13.39;

Protein crystallography data

The structure of Structure of Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4-(3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)Phenethyl)-6- Methylpyridin-2-Amine, PDB code: 3n5r was solved by S.L.Delker, H.Li, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.12 / 2.57
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 57.928, 106.708, 156.901, 90.00, 90.00, 90.00
R / Rfree (%) 18.2 / 24.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4-(3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)Phenethyl)-6- Methylpyridin-2-Amine (pdb code 3n5r). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4-(3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)Phenethyl)-6- Methylpyridin-2-Amine, PDB code: 3n5r:

Zinc binding site 1 out of 1 in 3n5r

Go back to Zinc Binding Sites List in 3n5r
Zinc binding site 1 out of 1 in the Structure of Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4-(3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)Phenethyl)-6- Methylpyridin-2-Amine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4-(3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)Phenethyl)-6- Methylpyridin-2-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn900

b:34.3
occ:1.00
SG B:CYS101 2.3 32.7 1.0
SG A:CYS101 2.3 33.0 1.0
SG B:CYS96 2.3 31.3 1.0
SG A:CYS96 2.4 37.5 1.0
CB A:CYS101 3.2 36.3 1.0
CB B:CYS101 3.2 36.2 1.0
CB B:CYS96 3.3 35.2 1.0
CB A:CYS96 3.4 40.0 1.0
CA A:CYS101 3.7 37.0 1.0
CA B:CYS101 3.7 37.5 1.0
N B:GLY103 4.1 36.5 1.0
N B:LEU102 4.1 38.3 1.0
N A:GLY103 4.1 33.8 1.0
N A:LEU102 4.1 35.8 1.0
C A:CYS101 4.3 36.2 1.0
CA A:GLY103 4.3 33.1 1.0
C B:CYS101 4.3 38.0 1.0
CA B:GLY103 4.5 35.5 1.0
CA B:CYS96 4.8 36.1 1.0
CA A:CYS96 4.8 41.5 1.0
N B:CYS101 4.9 38.5 1.0
N A:CYS101 4.9 39.2 1.0
C B:LEU102 5.0 36.9 1.0

Reference:

S.L.Delker, F.Xue, H.Li, J.Jamal, R.B.Silverman, T.L.Poulos. Role of Zinc in Isoform-Selective Inhibitor Binding to Neuronal Nitric Oxide Synthase . Biochemistry V. 49 10803 2010.
ISSN: ISSN 0006-2960
PubMed: 21138269
DOI: 10.1021/BI1013479
Page generated: Sat Sep 26 11:55:09 2020
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy