Zinc »
PDB 3mpv-3n2v »
3n2v »
Zinc in PDB 3n2v: Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide
Enzymatic activity of Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide
All present enzymatic activity of Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide:
3.4.24.65;
3.4.24.65;
Protein crystallography data
The structure of Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide, PDB code: 3n2v
was solved by
V.Calderone,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 14.44 / 1.55 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 51.614, 60.277, 54.186, 90.00, 115.20, 90.00 |
| R / Rfree (%) | 13.2 / 18 |
Other elements in 3n2v:
The structure of Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide also contains other interesting chemical elements:
| Calcium | (Ca) | 3 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide
(pdb code 3n2v). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide, PDB code: 3n2v:
Jump to Zinc binding site number: 1; 2;
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide, PDB code: 3n2v:
Jump to Zinc binding site number: 1; 2;
Zinc binding site 1 out of 2 in 3n2v
Go back to
Zinc Binding Sites List in 3n2v
Zinc binding site 1 out
of 2 in the Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide within 5.0Å range:
|
Zinc binding site 2 out of 2 in 3n2v
Go back to
Zinc Binding Sites List in 3n2v
Zinc binding site 2 out
of 2 in the Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide within 5.0Å range:
|
Reference:
E.Attolino,
V.Calderone,
E.Dragoni,
M.Fragai,
B.Richichi,
C.Luchinat,
C.Nativi.
Structure-Based Approach to Nanomolar, Water Soluble Matrix Metalloproteinases Inhibitors (Mmpis). Eur.J.Med.Chem. V. 45 5919 2010.
ISSN: ISSN 0223-5234
PubMed: 20965620
DOI: 10.1016/J.EJMECH.2010.09.057
Page generated: Sat Oct 26 09:56:22 2024
ISSN: ISSN 0223-5234
PubMed: 20965620
DOI: 10.1016/J.EJMECH.2010.09.057
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
