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Zinc in PDB 3ll8: Crystal Structure of Calcineurin in Complex with AKAP79 Peptide

Enzymatic activity of Crystal Structure of Calcineurin in Complex with AKAP79 Peptide

All present enzymatic activity of Crystal Structure of Calcineurin in Complex with AKAP79 Peptide:
3.1.3.16;

Protein crystallography data

The structure of Crystal Structure of Calcineurin in Complex with AKAP79 Peptide, PDB code: 3ll8 was solved by H.Li, P.G.Hogan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.15 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 86.275, 89.699, 158.914, 90.00, 90.00, 90.00
R / Rfree (%) 17.8 / 22.8

Other elements in 3ll8:

The structure of Crystal Structure of Calcineurin in Complex with AKAP79 Peptide also contains other interesting chemical elements:

Iron (Fe) 2 atoms
Calcium (Ca) 8 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Calcineurin in Complex with AKAP79 Peptide (pdb code 3ll8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Calcineurin in Complex with AKAP79 Peptide, PDB code: 3ll8:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 3ll8

Go back to Zinc Binding Sites List in 3ll8
Zinc binding site 1 out of 2 in the Crystal Structure of Calcineurin in Complex with AKAP79 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Calcineurin in Complex with AKAP79 Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn505

b:27.1
occ:1.00
OD1 A:ASN150 2.1 22.2 1.0
NE2 A:HIS199 2.1 24.1 1.0
ND1 A:HIS281 2.2 18.1 1.0
OD2 A:ASP118 2.3 19.7 1.0
O2 A:PO4500 2.3 28.8 1.0
CE1 A:HIS281 3.0 22.5 1.0
CD2 A:HIS199 3.1 27.5 1.0
CE1 A:HIS199 3.1 25.1 1.0
CG A:ASN150 3.2 25.1 1.0
CG A:ASP118 3.2 27.1 1.0
FE A:FE506 3.3 44.1 1.0
P A:PO4500 3.3 27.0 1.0
CG A:HIS281 3.4 21.2 1.0
OD1 A:ASP118 3.6 21.6 1.0
ND2 A:ASN150 3.6 21.2 1.0
O1 A:PO4500 3.6 26.6 1.0
CA A:HIS281 3.8 22.0 1.0
CB A:HIS281 3.9 23.0 1.0
O4 A:PO4500 4.0 30.2 1.0
O A:HIS281 4.1 24.1 1.0
OD2 A:ASP90 4.2 25.8 1.0
NE2 A:HIS281 4.2 20.5 1.0
ND1 A:HIS199 4.2 22.4 1.0
CG A:HIS199 4.3 22.4 1.0
CD2 A:HIS281 4.4 20.4 1.0
C A:HIS281 4.5 23.1 1.0
CD2 A:HIS151 4.5 21.1 1.0
CB A:ASN150 4.5 23.2 1.0
CB A:ASP118 4.5 24.7 1.0
N A:ASN150 4.5 24.2 1.0
O3 A:PO4500 4.6 29.2 1.0
N A:HIS281 4.8 21.9 1.0
O A:LEU231 4.8 24.5 1.0
NH1 A:ARG254 4.9 31.3 1.0

Zinc binding site 2 out of 2 in 3ll8

Go back to Zinc Binding Sites List in 3ll8
Zinc binding site 2 out of 2 in the Crystal Structure of Calcineurin in Complex with AKAP79 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Calcineurin in Complex with AKAP79 Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn512

b:27.7
occ:1.00
OD1 C:ASN150 2.1 25.6 1.0
NE2 C:HIS199 2.2 23.9 1.0
OD2 C:ASP118 2.2 18.7 1.0
ND1 C:HIS281 2.2 17.4 1.0
O2 C:PO4507 2.3 26.3 1.0
CE1 C:HIS281 3.1 21.0 1.0
CD2 C:HIS199 3.1 20.9 1.0
CG C:ASN150 3.2 25.1 1.0
CG C:ASP118 3.2 22.9 1.0
CE1 C:HIS199 3.2 23.1 1.0
FE C:FE513 3.2 43.8 1.0
CG C:HIS281 3.3 18.8 1.0
P C:PO4507 3.4 28.1 1.0
OD1 C:ASP118 3.5 20.5 1.0
ND2 C:ASN150 3.7 22.7 1.0
O1 C:PO4507 3.7 25.9 1.0
CA C:HIS281 3.8 21.9 1.0
CB C:HIS281 3.8 22.5 1.0
O C:HIS281 4.0 25.0 1.0
O4 C:PO4507 4.0 29.3 1.0
OD2 C:ASP90 4.1 23.7 1.0
NE2 C:HIS281 4.3 19.0 1.0
CG C:HIS199 4.3 21.8 1.0
ND1 C:HIS199 4.3 20.7 1.0
CD2 C:HIS281 4.4 17.9 1.0
C C:HIS281 4.4 24.1 1.0
CB C:ASP118 4.4 23.0 1.0
CB C:ASN150 4.5 22.2 1.0
CD2 C:HIS151 4.5 23.7 1.0
N C:ASN150 4.5 23.9 1.0
O3 C:PO4507 4.6 27.6 1.0
N C:HIS281 4.8 21.4 1.0
NH1 C:ARG254 4.9 24.6 1.0
O C:LEU231 4.9 23.1 1.0
CG C:ASP90 5.0 27.5 1.0
O C:HOH601 5.0 22.9 1.0
CA C:ASN150 5.0 23.7 1.0

Reference:

H.Li, M.D.Pink, J.G.Murphy, A.Stein, M.L.Dell'acqua, P.G.Hogan. Balanced Interactions of Calcineurin with AKAP79 Regulate Ca(2+)-Calcineurin-Nfat Signaling. Nat.Struct.Mol.Biol. V. 19 337 2012.
ISSN: ISSN 1545-9993
PubMed: 22343722
DOI: 10.1038/NSMB.2238
Page generated: Wed Dec 16 04:32:32 2020

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