Zinc in PDB 3jsd: Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus

The structure of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus, PDB code: 3jsd was solved by M.A.Weiss, Z.L.Wan, E.J.Dodson, M.Liu, B.Xu, Q.X.Hua, M.Turkenburg, J.Whittingham, S.H.Nakagawa, K.Huang, S.Q.Hu, W.H.Jia, S.H.Wang, J.Brange, J.Whittaker, P.Arvan, P.G.Katsoyannis, G.G.Dodson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	17.37 / 2.50
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	80.843, 80.843, 38.842, 90.00, 90.00, 120.00
R / Rfree (%)	20.6 / 27.4

The structure of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Zinc atom in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus (pdb code 3jsd). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus, PDB code: 3jsd:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn31 b:2.4 occ:0.33 NE2 B:HIS10 2.1 25.8 1.0 CL B:CL32 2.2 5.3 0.3 CE1 B:HIS10 2.9 24.6 1.0 CD2 B:HIS10 3.2 25.8 1.0 ND1 B:HIS10 4.1 27.2 1.0 CG B:HIS10 4.2 28.2 1.0

Zinc binding site 2 out of 2 in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn31 b:1.5 occ:0.33 NE2 D:HIS10 2.1 29.7 1.0 CL D:CL32 2.3 1.0 0.3 CE1 D:HIS10 2.9 28.9 1.0 CD2 D:HIS10 3.1 31.6 1.0 ND1 D:HIS10 4.1 29.4 1.0 CG D:HIS10 4.2 28.8 1.0 O D:LEU6 4.6 38.3 1.0

M.A.Weiss, Z.L.Wan, E.J.Dodson, M.Liu, B.Xu, Q.X.Hua, M.Turkenburg, J.Whittingham, S.H.Nakagawa, K.Huang, S.Q.Hu, W.H.Jia, S.H.Wang, J.Brange, J.Whittaker, P.Arvan, P.G.Katsoyannis, G.G.Dodson. Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus To Be Published.