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Zinc in PDB 3io2: Crystal Structure of the TAZ2 Domain of P300

Enzymatic activity of Crystal Structure of the TAZ2 Domain of P300

All present enzymatic activity of Crystal Structure of the TAZ2 Domain of P300:
2.3.1.48;

Protein crystallography data

The structure of Crystal Structure of the TAZ2 Domain of P300, PDB code: 3io2 was solved by M.Miller, Z.Dauter, A.Wlodawer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.35 / 2.50
Space group I 41 3 2
Cell size a, b, c (Å), α, β, γ (°) 155.270, 155.270, 155.270, 90.00, 90.00, 90.00
R / Rfree (%) 20.6 / 23.6

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the TAZ2 Domain of P300 (pdb code 3io2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of the TAZ2 Domain of P300, PDB code: 3io2:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in 3io2

Go back to Zinc Binding Sites List in 3io2
Zinc binding site 1 out of 3 in the Crystal Structure of the TAZ2 Domain of P300


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the TAZ2 Domain of P300 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn201

b:47.9
occ:1.00
NE2 A:HIS1744 2.2 34.6 1.0
SG A:CYS1753 2.3 35.2 1.0
SG A:CYS1748 2.3 25.6 1.0
SG A:CYS1758 2.4 26.4 1.0
CB A:CYS1753 2.9 45.6 1.0
CD2 A:HIS1744 3.0 31.7 1.0
CB A:CYS1748 3.1 21.0 1.0
CE1 A:HIS1744 3.2 28.2 1.0
CB A:CYS1758 3.5 24.8 1.0
CG A:HIS1744 4.2 32.4 1.0
ND1 A:HIS1744 4.3 36.4 1.0
CA A:CYS1753 4.4 45.5 1.0
CA A:CYS1748 4.5 26.4 1.0
CD1 A:LEU1755 4.6 17.4 1.0
O A:ASN1750 4.8 45.5 1.0
CA A:CYS1758 4.8 29.6 1.0

Zinc binding site 2 out of 3 in 3io2

Go back to Zinc Binding Sites List in 3io2
Zinc binding site 2 out of 3 in the Crystal Structure of the TAZ2 Domain of P300


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the TAZ2 Domain of P300 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn202

b:43.7
occ:1.00
NE2 A:HIS1767 2.0 29.7 1.0
SG A:CYS1779 2.3 26.6 1.0
SG A:CYS1782 2.3 26.2 1.0
SG A:CYS1771 2.4 26.3 1.0
CE1 A:HIS1767 3.0 19.5 1.0
CD2 A:HIS1767 3.1 22.0 1.0
CB A:CYS1771 3.2 25.0 1.0
CB A:CYS1779 3.2 21.8 1.0
CB A:CYS1782 3.6 25.1 1.0
N A:CYS1782 3.9 26.8 1.0
ND1 A:HIS1767 4.1 25.6 1.0
CG A:HIS1767 4.2 28.1 1.0
CA A:CYS1782 4.3 26.0 1.0
CA A:LYS1774 4.4 27.7 1.0
CB A:ILE1781 4.6 18.7 1.0
CA A:CYS1779 4.6 21.3 1.0
CA A:CYS1771 4.6 29.8 1.0
N A:LYS1774 4.7 29.2 1.0
C A:ILE1781 4.9 24.1 1.0
C A:CYS1779 5.0 21.2 1.0
O A:HIS1767 5.0 30.1 1.0

Zinc binding site 3 out of 3 in 3io2

Go back to Zinc Binding Sites List in 3io2
Zinc binding site 3 out of 3 in the Crystal Structure of the TAZ2 Domain of P300


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the TAZ2 Domain of P300 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn203

b:41.9
occ:1.00
NE2 A:HIS1792 2.2 24.6 1.0
SG A:CYS1801 2.3 23.1 1.0
SG A:CYS1806 2.4 22.7 1.0
SG A:CYS1796 2.5 26.9 1.0
CD2 A:HIS1792 3.1 24.8 1.0
CB A:CYS1801 3.1 23.9 1.0
CB A:CYS1796 3.2 32.3 1.0
CE1 A:HIS1792 3.3 18.6 1.0
CB A:CYS1806 3.3 16.5 1.0
NZ A:LYS1810 4.2 34.9 1.0
CG A:HIS1792 4.3 23.6 1.0
O A:HOH24 4.3 22.6 1.0
ND1 A:HIS1792 4.3 21.7 1.0
CB A:VAL1803 4.4 23.0 1.0
CA A:CYS1801 4.5 26.0 1.0
CG2 A:VAL1803 4.6 10.4 1.0
CA A:CYS1796 4.7 36.0 1.0
CA A:CYS1806 4.7 18.4 1.0
CB A:GLU1798 4.9 33.9 1.0
CE A:LYS1810 5.0 32.9 1.0
O A:GLU1798 5.0 36.5 1.0

Reference:

M.Miller, Z.Dauter, S.Cherry, J.E.Tropea, A.Wlodawer. Structure of the TAZ2 Domain of P300: Insights Into Ligand Binding. Acta Crystallogr.,Sect.D V. 65 1301 2009.
ISSN: ISSN 0907-4449
PubMed: 19966416
DOI: 10.1107/S0907444909040153
Page generated: Wed Dec 16 04:26:36 2020

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