Zinc in PDB 3io2: Crystal Structure of the TAZ2 Domain of P300

All present enzymatic activity of Crystal Structure of the TAZ2 Domain of P300:
2.3.1.48;

The structure of Crystal Structure of the TAZ2 Domain of P300, PDB code: 3io2 was solved by M.Miller, Z.Dauter, A.Wlodawer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.35 / 2.50
Space group	I 41 3 2
Cell size a, b, c (Å), α, β, γ (°)	155.270, 155.270, 155.270, 90.00, 90.00, 90.00
R / Rfree (%)	20.6 / 23.6

The binding sites of Zinc atom in the Crystal Structure of the TAZ2 Domain of P300 (pdb code 3io2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of the TAZ2 Domain of P300, PDB code: 3io2:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Crystal Structure of the TAZ2 Domain of P300


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the TAZ2 Domain of P300 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:47.9 occ:1.00 NE2 A:HIS1744 2.2 34.6 1.0 SG A:CYS1753 2.3 35.2 1.0 SG A:CYS1748 2.3 25.6 1.0 SG A:CYS1758 2.4 26.4 1.0 CB A:CYS1753 2.9 45.6 1.0 CD2 A:HIS1744 3.0 31.7 1.0 CB A:CYS1748 3.1 21.0 1.0 CE1 A:HIS1744 3.2 28.2 1.0 CB A:CYS1758 3.5 24.8 1.0 CG A:HIS1744 4.2 32.4 1.0 ND1 A:HIS1744 4.3 36.4 1.0 CA A:CYS1753 4.4 45.5 1.0 CA A:CYS1748 4.5 26.4 1.0 CD1 A:LEU1755 4.6 17.4 1.0 O A:ASN1750 4.8 45.5 1.0 CA A:CYS1758 4.8 29.6 1.0

Zinc binding site 2 out of 3 in the Crystal Structure of the TAZ2 Domain of P300


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the TAZ2 Domain of P300 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn202 b:43.7 occ:1.00 NE2 A:HIS1767 2.0 29.7 1.0 SG A:CYS1779 2.3 26.6 1.0 SG A:CYS1782 2.3 26.2 1.0 SG A:CYS1771 2.4 26.3 1.0 CE1 A:HIS1767 3.0 19.5 1.0 CD2 A:HIS1767 3.1 22.0 1.0 CB A:CYS1771 3.2 25.0 1.0 CB A:CYS1779 3.2 21.8 1.0 CB A:CYS1782 3.6 25.1 1.0 N A:CYS1782 3.9 26.8 1.0 ND1 A:HIS1767 4.1 25.6 1.0 CG A:HIS1767 4.2 28.1 1.0 CA A:CYS1782 4.3 26.0 1.0 CA A:LYS1774 4.4 27.7 1.0 CB A:ILE1781 4.6 18.7 1.0 CA A:CYS1779 4.6 21.3 1.0 CA A:CYS1771 4.6 29.8 1.0 N A:LYS1774 4.7 29.2 1.0 C A:ILE1781 4.9 24.1 1.0 C A:CYS1779 5.0 21.2 1.0 O A:HIS1767 5.0 30.1 1.0

Zinc binding site 3 out of 3 in the Crystal Structure of the TAZ2 Domain of P300


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the TAZ2 Domain of P300 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn203 b:41.9 occ:1.00 NE2 A:HIS1792 2.2 24.6 1.0 SG A:CYS1801 2.3 23.1 1.0 SG A:CYS1806 2.4 22.7 1.0 SG A:CYS1796 2.5 26.9 1.0 CD2 A:HIS1792 3.1 24.8 1.0 CB A:CYS1801 3.1 23.9 1.0 CB A:CYS1796 3.2 32.3 1.0 CE1 A:HIS1792 3.3 18.6 1.0 CB A:CYS1806 3.3 16.5 1.0 NZ A:LYS1810 4.2 34.9 1.0 CG A:HIS1792 4.3 23.6 1.0 O A:HOH24 4.3 22.6 1.0 ND1 A:HIS1792 4.3 21.7 1.0 CB A:VAL1803 4.4 23.0 1.0 CA A:CYS1801 4.5 26.0 1.0 CG2 A:VAL1803 4.6 10.4 1.0 CA A:CYS1796 4.7 36.0 1.0 CA A:CYS1806 4.7 18.4 1.0 CB A:GLU1798 4.9 33.9 1.0 CE A:LYS1810 5.0 32.9 1.0 O A:GLU1798 5.0 36.5 1.0

M.Miller, Z.Dauter, S.Cherry, J.E.Tropea, A.Wlodawer. Structure of the TAZ2 Domain of P300: Insights Into Ligand Binding. Acta Crystallogr.,Sect.D V. 65 1301 2009.
ISSN: ISSN 0907-4449
PubMed: 19966416
DOI: 10.1107/S0907444909040153