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Atomistry » Zinc » PDB 3hjt-3hqh » 3hkt » |
Zinc in PDB 3hkt: Human Carbonic Anhydrase II in Complex with Alpha-D-Glucopyranosyl-(1- >4)-1-Thio-Beta-D-GlucopyranosylsulfonamideEnzymatic activity of Human Carbonic Anhydrase II in Complex with Alpha-D-Glucopyranosyl-(1- >4)-1-Thio-Beta-D-Glucopyranosylsulfonamide
All present enzymatic activity of Human Carbonic Anhydrase II in Complex with Alpha-D-Glucopyranosyl-(1- >4)-1-Thio-Beta-D-Glucopyranosylsulfonamide:
4.2.1.1; Protein crystallography data
The structure of Human Carbonic Anhydrase II in Complex with Alpha-D-Glucopyranosyl-(1- >4)-1-Thio-Beta-D-Glucopyranosylsulfonamide, PDB code: 3hkt
was solved by
B.Paul,
S.-A.Poulsen,
A.Hofmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Human Carbonic Anhydrase II in Complex with Alpha-D-Glucopyranosyl-(1- >4)-1-Thio-Beta-D-Glucopyranosylsulfonamide
(pdb code 3hkt). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Carbonic Anhydrase II in Complex with Alpha-D-Glucopyranosyl-(1- >4)-1-Thio-Beta-D-Glucopyranosylsulfonamide, PDB code: 3hkt: Zinc binding site 1 out of 1 in 3hktGo back to Zinc Binding Sites List in 3hkt
Zinc binding site 1 out
of 1 in the Human Carbonic Anhydrase II in Complex with Alpha-D-Glucopyranosyl-(1- >4)-1-Thio-Beta-D-Glucopyranosylsulfonamide
Mono view Stereo pair view
Reference:
M.Lopez,
B.Paul,
A.Hofmann,
J.Morizzi,
Q.K.Wu,
S.A.Charman,
A.Innocenti,
D.Vullo,
C.T.Supuran,
S.A.Poulsen.
S-Glycosyl Primary Sulfonamides--A New Structural Class For Selective Inhibition of Cancer-Associated Carbonic Anhydrases. J.Med.Chem. V. 52 6421 2009.
Page generated: Wed Dec 16 04:24:03 2020
ISSN: ISSN 0022-2623 PubMed: 19827837 DOI: 10.1021/JM900914E |
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