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Atomistry » Zinc » PDB 3g8q-3gj9 » 3ge7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 3g8q-3gj9 » 3ge7 » |
Zinc in PDB 3ge7: Trna-Guanine Transglycosylase in Complex with 6-Amino-4-{2- [(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-OneEnzymatic activity of Trna-Guanine Transglycosylase in Complex with 6-Amino-4-{2- [(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One
All present enzymatic activity of Trna-Guanine Transglycosylase in Complex with 6-Amino-4-{2- [(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One:
2.4.2.29; Protein crystallography data
The structure of Trna-Guanine Transglycosylase in Complex with 6-Amino-4-{2- [(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One, PDB code: 3ge7
was solved by
T.Ritschel,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Trna-Guanine Transglycosylase in Complex with 6-Amino-4-{2- [(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One
(pdb code 3ge7). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase in Complex with 6-Amino-4-{2- [(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One, PDB code: 3ge7: Zinc binding site 1 out of 1 in 3ge7Go back to Zinc Binding Sites List in 3ge7
Zinc binding site 1 out
of 1 in the Trna-Guanine Transglycosylase in Complex with 6-Amino-4-{2- [(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One
Mono view Stereo pair view
Reference:
T.Ritschel,
P.C.Kohler,
G.Neudert,
A.Heine,
F.Diederich,
G.Klebe.
How to Replace the Residual Solvation Shell of Polar Active Site Residues to Achieve Nanomolar Inhibition of Trna-Guanine Transglycosylase Chemmedchem V. 4 2012 2009.
Page generated: Thu Oct 24 13:41:49 2024
ISSN: ISSN 1860-7179 PubMed: 19894214 DOI: 10.1002/CMDC.200900343 |
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