Zinc in PDB 3g6t: Gr Gamma Dna-Binding Domain:FKBP5 16BP Complex-34

The structure of Gr Gamma Dna-Binding Domain:FKBP5 16BP Complex-34, PDB code: 3g6t was solved by M.A.Pufall, K.R.Yamamoto, S.H.Meijsing, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.09 / 1.90
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	115.693, 39.716, 95.228, 90.00, 122.79, 90.00
R / Rfree (%)	17.9 / 21.4

The binding sites of Zinc atom in the Gr Gamma Dna-Binding Domain:FKBP5 16BP Complex-34 (pdb code 3g6t). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Gr Gamma Dna-Binding Domain:FKBP5 16BP Complex-34, PDB code: 3g6t:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Gr Gamma Dna-Binding Domain:FKBP5 16BP Complex-34


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Gr Gamma Dna-Binding Domain:FKBP5 16BP Complex-34 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn527 b:39.0 occ:1.00 SG A:CYS443 2.3 37.9 1.0 SG A:CYS460 2.3 34.6 1.0 SG A:CYS457 2.4 39.5 1.0 SG A:CYS440 2.4 38.7 1.0 CB A:CYS440 3.2 35.9 1.0 CB A:CYS443 3.2 40.6 1.0 CB A:CYS460 3.4 30.8 1.0 CB A:CYS457 3.7 42.7 1.0 N A:CYS443 3.7 36.5 1.0 N A:CYS457 3.9 41.5 1.0 CA A:CYS443 4.0 42.2 1.0 N A:CYS460 4.2 31.6 1.0 CA A:CYS457 4.3 36.5 1.0 CA A:CYS460 4.4 34.0 1.0 OG A:SER459 4.4 42.1 1.0 NH1 A:ARG490 4.4 40.8 1.0 CB A:VAL442 4.5 40.8 1.0 CB A:ASP445 4.5 48.3 1.0 C A:CYS443 4.6 48.9 1.0 CA A:CYS440 4.7 44.2 1.0 C A:VAL442 4.8 48.6 1.0 N A:SER444 4.8 43.4 1.0 O A:CYS457 4.8 38.0 1.0 N A:ASP445 4.8 47.8 1.0 NH2 A:ARG497 4.8 36.6 1.0 C A:CYS457 4.9 39.7 1.0 C A:THR456 5.0 45.4 1.0

Zinc binding site 2 out of 4 in the Gr Gamma Dna-Binding Domain:FKBP5 16BP Complex-34


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Gr Gamma Dna-Binding Domain:FKBP5 16BP Complex-34 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn528 b:35.2 occ:1.00 SG A:CYS483 2.2 34.1 1.0 SG A:CYS493 2.3 34.7 1.0 SG A:CYS496 2.3 34.5 1.0 SG A:CYS477 2.4 33.4 1.0 CB A:CYS483 3.2 33.6 1.0 CB A:CYS493 3.3 31.1 1.0 CB A:CYS477 3.4 31.6 1.0 CB A:CYS496 3.4 28.0 1.0 O B:HOH2 3.9 36.4 1.0 N A:CYS483 3.9 33.1 1.0 CA A:CYS477 4.0 34.1 1.0 N A:CYS496 4.2 30.5 1.0 CA A:CYS483 4.2 35.5 1.0 CA A:CYS496 4.3 27.2 1.0 CA A:ASN481 4.4 39.5 1.0 O B:HOH18 4.5 37.5 1.0 N A:ASN481 4.6 38.5 1.0 N A:ASP482 4.6 32.6 1.0 O A:HOH5 4.6 39.6 1.0 N A:GLY479 4.7 36.7 1.0 N A:ALA478 4.8 35.2 1.0 CA A:CYS493 4.8 31.8 1.0 C A:CYS477 4.8 39.2 1.0 C A:ASN481 4.8 41.5 1.0 O A:HOH9 4.8 35.0 1.0

Zinc binding site 3 out of 4 in the Gr Gamma Dna-Binding Domain:FKBP5 16BP Complex-34


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Gr Gamma Dna-Binding Domain:FKBP5 16BP Complex-34 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn527 b:68.4 occ:1.00 SG B:CYS457 2.3 68.5 1.0 SG B:CYS443 2.4 68.9 1.0 SG B:CYS440 2.4 69.9 1.0 SG B:CYS460 2.4 71.7 1.0 CB B:CYS460 3.1 59.1 1.0 CB B:CYS440 3.2 83.2 1.0 CB B:CYS443 3.3 62.9 1.0 N B:CYS443 3.5 69.6 1.0 CB B:CYS457 3.5 70.2 1.0 N B:CYS457 3.9 80.7 1.0 CA B:CYS443 3.9 69.4 1.0 NH1 B:ARG490 4.2 71.3 1.0 CA B:CYS460 4.2 63.1 1.0 N B:CYS460 4.2 68.0 1.0 CA B:CYS457 4.3 79.7 1.0 OG B:SER459 4.4 62.8 1.0 CB B:ASP445 4.4 67.2 1.0 CB B:VAL442 4.4 60.0 1.0 C B:CYS443 4.6 80.2 1.0 C B:VAL442 4.6 69.6 1.0 N B:ASP445 4.7 78.0 1.0 CA B:CYS440 4.7 78.7 1.0 N B:SER444 4.7 87.9 1.0 NH2 B:ARG497 4.8 53.1 1.0 CA B:VAL442 4.9 69.6 1.0 CG1 B:VAL442 4.9 59.6 1.0 N B:VAL442 4.9 77.0 1.0 C B:CYS457 5.0 72.9 1.0 CD B:ARG490 5.0 63.9 1.0

Zinc binding site 4 out of 4 in the Gr Gamma Dna-Binding Domain:FKBP5 16BP Complex-34


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Gr Gamma Dna-Binding Domain:FKBP5 16BP Complex-34 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn528 b:38.2 occ:1.00 SG B:CYS477 2.3 33.9 1.0 SG B:CYS483 2.3 37.4 1.0 SG B:CYS493 2.4 37.9 1.0 SG B:CYS496 2.4 37.8 1.0 CB B:CYS477 3.2 38.4 1.0 CB B:CYS483 3.3 35.3 1.0 CB B:CYS493 3.4 45.8 1.0 CB B:CYS496 3.4 39.0 1.0 N B:CYS483 3.9 38.6 1.0 O B:HOH12 3.9 40.2 1.0 CA B:CYS477 4.0 34.3 1.0 O B:HOH7 4.1 41.1 1.0 N B:CYS496 4.2 46.5 1.0 CA B:CYS483 4.2 31.4 1.0 CA B:CYS496 4.4 42.8 1.0 CA B:ASN481 4.5 42.4 1.0 N B:ASN481 4.6 32.1 1.0 N B:ASP482 4.6 34.6 1.0 O B:HOH18 4.6 37.5 1.0 N B:ALA478 4.7 32.7 1.0 C B:CYS477 4.8 32.0 1.0 CA B:CYS493 4.8 39.2 1.0 C B:ASN481 4.8 42.5 1.0 N B:GLY479 4.8 41.5 1.0 O B:HOH49 4.8 60.0 1.0

S.H.Meijsing, M.A.Pufall, A.Y.So, D.L.Bates, L.Chen, K.R.Yamamoto. Dna Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity. Science V. 324 407 2009.
ISSN: ISSN 0036-8075
PubMed: 19372434
DOI: 10.1126/SCIENCE.1164265