Zinc in PDB 3fqq: Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein

The structure of Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein, PDB code: 3fqq was solved by R.A.Love, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.20
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	57.106, 57.106, 197.365, 90.00, 90.00, 120.00
R / Rfree (%)	22.2 / 25.5

The binding sites of Zinc atom in the Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein (pdb code 3fqq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein, PDB code: 3fqq:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn901 b:22.1 occ:1.00 SG A:CYS39 2.2 22.9 1.0 SG A:CYS57 2.4 21.7 1.0 SG A:CYS80 2.4 23.5 1.0 SG A:CYS59 2.4 24.9 1.0 CB A:CYS59 3.2 24.7 1.0 CB A:CYS57 3.3 21.0 1.0 CB A:CYS39 3.3 23.7 1.0 CB A:CYS80 3.4 24.2 1.0 CA A:CYS80 3.7 24.5 1.0 CA A:CYS39 3.7 23.9 1.0 N A:SER81 4.0 24.1 1.0 ND2 A:ASN82 4.1 16.6 1.0 N A:CYS59 4.3 24.4 1.0 C A:CYS80 4.3 24.1 1.0 CA A:CYS59 4.3 24.6 1.0 CB A:ALA61 4.5 24.5 1.0 N A:CYS39 4.5 24.8 1.0 CA A:CYS57 4.6 21.4 1.0 N A:ASN82 4.7 23.1 1.0 C A:CYS39 4.9 23.4 1.0 N A:CYS80 4.9 25.3 1.0 C A:CYS57 4.9 22.0 1.0 N A:GLN40 4.9 22.5 1.0 O A:THR79 5.0 27.8 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn902 b:24.5 occ:1.00 SG B:CYS80 2.2 24.8 1.0 SG B:CYS59 2.3 27.8 1.0 SG B:CYS39 2.4 29.8 1.0 SG B:CYS57 2.5 23.9 1.0 CB B:CYS80 3.1 25.9 1.0 CB B:CYS57 3.2 23.6 1.0 CB B:CYS39 3.4 32.5 1.0 CB B:CYS59 3.4 27.6 1.0 CA B:CYS80 3.6 26.4 1.0 CA B:CYS39 3.9 32.6 1.0 N B:SER81 4.1 26.2 1.0 ND2 B:ASN82 4.2 16.1 1.0 C B:CYS80 4.2 26.2 1.0 N B:CYS59 4.3 26.5 1.0 CA B:CYS59 4.5 27.6 1.0 CB B:ALA61 4.5 26.2 1.0 CA B:CYS57 4.6 23.8 1.0 N B:CYS39 4.7 34.6 1.0 N B:CYS80 4.8 26.4 1.0 N B:ASN82 4.8 25.0 1.0 C B:CYS57 4.9 24.2 1.0 O B:THR79 5.0 27.2 1.0

R.A.Love, O.Brodsky, M.J.Hickey, P.A.Wells, C.N.Cronin. Crystal Structure of A Novel Dimeric Form of NS5A Domain I Protein From Hepatitis C Virus J.Virol. V. 83 4395 2009.
ISSN: ISSN 0022-538X
PubMed: 19244328
DOI: 10.1128/JVI.02352-08