Zinc in PDB 3fqm: Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein

The structure of Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein, PDB code: 3fqm was solved by R.A.Love, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.77 / 1.90
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	57.165, 57.165, 195.385, 90.00, 90.00, 120.00
R / Rfree (%)	24.7 / 28.8

The binding sites of Zinc atom in the Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein (pdb code 3fqm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein, PDB code: 3fqm:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn901 b:26.1 occ:1.00 SG A:CYS59 2.2 28.1 1.0 SG A:CYS39 2.3 27.4 1.0 SG A:CYS57 2.4 23.9 1.0 SG A:CYS80 2.4 29.1 1.0 CB A:CYS57 3.1 24.0 1.0 CB A:CYS59 3.1 27.5 1.0 CB A:CYS80 3.3 29.6 1.0 CB A:CYS39 3.3 26.0 1.0 CA A:CYS80 3.6 29.9 1.0 CA A:CYS39 3.7 26.1 1.0 N A:SER81 4.1 29.3 1.0 N A:CYS59 4.2 27.6 1.0 ND2 A:ASN82 4.2 23.4 1.0 CA A:CYS59 4.2 27.7 1.0 C A:CYS80 4.3 29.4 1.0 CB A:ALA61 4.5 26.5 1.0 CA A:CYS57 4.5 24.2 1.0 N A:CYS39 4.5 27.1 1.0 C A:CYS57 4.8 24.6 1.0 N A:ASN82 4.8 28.2 1.0 O A:THR79 4.8 31.4 1.0 N A:CYS80 4.8 30.3 1.0 C A:CYS39 4.9 25.3 1.0 N A:GLN40 4.9 24.2 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of A Novel Dimeric Form of Hcv NS5A Domain I Protein within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn902 b:27.6 occ:1.00 SG B:CYS80 1.9 28.1 1.0 SG B:CYS59 2.2 29.4 1.0 SG B:CYS39 2.4 30.4 1.0 SG B:CYS57 2.4 27.4 1.0 CB B:CYS80 3.1 28.8 1.0 CB B:CYS59 3.2 27.4 1.0 CB B:CYS57 3.2 25.9 1.0 CB B:CYS39 3.3 34.3 1.0 CA B:CYS80 3.6 29.1 1.0 CA B:CYS39 3.8 34.0 1.0 N B:CYS59 4.0 27.4 1.0 N B:SER81 4.1 28.8 1.0 CA B:CYS59 4.2 28.2 1.0 ND2 B:ASN82 4.2 21.8 1.0 C B:CYS80 4.3 28.8 1.0 CB B:ALA61 4.4 27.9 1.0 CA B:CYS57 4.6 25.6 1.0 N B:CYS39 4.6 35.4 1.0 C B:CYS57 4.8 25.8 1.0 N B:CYS80 4.8 29.5 1.0 O B:THR79 4.9 30.5 1.0 N B:ASN82 4.9 27.4 1.0 C B:CYS39 4.9 34.0 1.0 N B:GLN40 5.0 32.8 1.0

R.A.Love, O.Brodsky, M.J.Hickey, P.A.Wells, C.N.Cronin. Crystal Structure of A Novel Dimeric Form of NS5A Domain I Protein From Hepatitis C Virus J.Virol. V. 83 4395 2009.
ISSN: ISSN 0022-538X
PubMed: 19244328
DOI: 10.1128/JVI.02352-08