Zinc in PDB 3fq9: Design of An Insulin Analog with Enhanced Receptor-Binding Selectivity. Rationale, Structure, and Therapeutic Implications

The structure of Design of An Insulin Analog with Enhanced Receptor-Binding Selectivity. Rationale, Structure, and Therapeutic Implications, PDB code: 3fq9 was solved by M.Zhao, Z.L.Wan, L.Whittaker, B.Xu, N.Phillips, P.Katsoyannis, J.Whittaker, M.A.Weiss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.92 / 1.35
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	81.841, 81.841, 33.518, 90.00, 90.00, 120.00
R / Rfree (%)	19.8 / 22.8

The binding sites of Zinc atom in the Design of An Insulin Analog with Enhanced Receptor-Binding Selectivity. Rationale, Structure, and Therapeutic Implications (pdb code 3fq9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Design of An Insulin Analog with Enhanced Receptor-Binding Selectivity. Rationale, Structure, and Therapeutic Implications, PDB code: 3fq9:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Design of An Insulin Analog with Enhanced Receptor-Binding Selectivity. Rationale, Structure, and Therapeutic Implications


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Design of An Insulin Analog with Enhanced Receptor-Binding Selectivity. Rationale, Structure, and Therapeutic Implications within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn101 b:1.0 occ:0.33 HE2 B:HIS10 1.3 18.1 1.0 NE2 B:HIS10 2.1 8.6 1.0 O B:HOH32 2.4 19.5 1.0 CE1 B:HIS10 2.9 10.1 1.0 HE1 B:HIS10 3.2 18.1 1.0 CD2 B:HIS10 3.2 8.9 1.0 HD2 B:HIS10 3.4 18.1 1.0 ND1 B:HIS10 4.1 10.6 1.0 CG B:HIS10 4.3 8.7 1.0 O B:HOH34 4.4 26.7 1.0

Zinc binding site 2 out of 2 in the Design of An Insulin Analog with Enhanced Receptor-Binding Selectivity. Rationale, Structure, and Therapeutic Implications


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Design of An Insulin Analog with Enhanced Receptor-Binding Selectivity. Rationale, Structure, and Therapeutic Implications within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn102 b:1.9 occ:0.33 HE2 D:HIS10 1.3 18.1 1.0 NE2 D:HIS10 2.1 10.6 1.0 O D:HOH33 2.6 19.7 1.0 CE1 D:HIS10 3.0 10.1 1.0 CD2 D:HIS10 3.1 9.8 1.0 HE1 D:HIS10 3.2 18.1 1.0 HD2 D:HIS10 3.4 18.1 1.0 ND1 D:HIS10 4.1 10.3 1.0 O D:HOH31 4.2 18.7 0.3 CG D:HIS10 4.2 10.0 1.0 HD1 D:HIS10 5.0 18.1 1.0

M.Zhao, Z.L.Wan, L.Whittaker, B.Xu, N.B.Phillips, P.G.Katsoyannis, F.Ismail-Beigi, J.Whittaker, M.A.Weiss. Design of An Insulin Analog with Enhanced Receptor Binding Selectivity: Rationale, Structure, and Therapeutic Implications. J.Biol.Chem. V. 284 32178 2009.
ISSN: ISSN 0021-9258
PubMed: 19773552
DOI: 10.1074/JBC.M109.028399