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Atomistry » Zinc » PDB 3f7k-3fkg » 3fh8 » |
Zinc in PDB 3fh8: Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine.Enzymatic activity of Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine.
All present enzymatic activity of Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine.:
3.3.2.6; Protein crystallography data
The structure of Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine., PDB code: 3fh8
was solved by
B.Mamat,
D.R.Davies,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3fh8:
The structure of Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine. also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine.
(pdb code 3fh8). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine., PDB code: 3fh8: Zinc binding site 1 out of 1 in 3fh8Go back to Zinc Binding Sites List in 3fh8
Zinc binding site 1 out
of 1 in the Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine.
Mono view Stereo pair view
Reference:
V.Sandanayaka,
B.Mamat,
R.K.Mishra,
J.Winger,
M.Krohn,
L.M.Zhou,
M.Keyvan,
L.Enache,
D.Sullins,
E.Onua,
J.Zhang,
G.Halldorsdottir,
H.Sigthorsdottir,
A.Thorlaksdottir,
G.Sigthorsson,
M.Thorsteinnsdottir,
D.R.Davies,
L.J.Stewart,
D.E.Zembower,
T.Andresson,
A.S.Kiselyov,
J.Singh,
M.E.Gurney.
Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy) Phenoxy]Methyl}-1-Pyrrolidinyl]Butanoic Acid (Dg-051) As A Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis. J.Med.Chem. V. 53 573 2010.
Page generated: Thu Oct 24 13:12:58 2024
ISSN: ISSN 0022-2623 PubMed: 19950900 DOI: 10.1021/JM900838G |
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