Zinc in PDB 3edg: Crystal Structure of Bone Morphogenetic Protein 1 Protease Domain

All present enzymatic activity of Crystal Structure of Bone Morphogenetic Protein 1 Protease Domain:
3.4.24.19;

The structure of Crystal Structure of Bone Morphogenetic Protein 1 Protease Domain, PDB code: 3edg was solved by A.Mac Sweeney, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.02 / 1.27
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	55.432, 57.260, 68.800, 90.00, 90.00, 90.00
R / Rfree (%)	14.4 / 17.7

The binding sites of Zinc atom in the Crystal Structure of Bone Morphogenetic Protein 1 Protease Domain (pdb code 3edg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Bone Morphogenetic Protein 1 Protease Domain, PDB code: 3edg:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Bone Morphogenetic Protein 1 Protease Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Bone Morphogenetic Protein 1 Protease Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn210 b:6.9 occ:1.00 NE2 A:HIS92 2.1 6.7 1.0 NE2 A:HIS102 2.1 5.8 1.0 NE2 A:HIS96 2.1 5.7 1.0 CE1 A:HIS102 3.0 7.0 1.0 CD2 A:HIS102 3.0 6.8 1.0 CD2 A:HIS92 3.1 7.2 1.0 CE1 A:HIS92 3.1 6.4 1.0 CE1 A:HIS96 3.1 6.3 1.0 CD2 A:HIS96 3.1 5.9 1.0 O A:HOH480 4.1 26.9 1.0 OE2 A:GLU93 4.1 16.7 1.0 ND1 A:HIS102 4.1 7.1 1.0 CG A:HIS102 4.2 6.2 1.0 ND1 A:HIS92 4.2 6.8 1.0 ND1 A:HIS96 4.2 6.2 1.0 CG A:HIS92 4.2 5.7 1.0 O A:HOH331 4.2 20.4 1.0 CG A:HIS96 4.3 6.3 1.0 O A:HOH510 4.6 37.0 1.0 O A:HOH342 4.6 19.7 1.0 CE A:MET147 4.7 7.4 1.0 O A:HOH418 4.8 24.6 1.0 CD A:GLU93 4.8 12.8 1.0 OE1 A:GLU93 4.9 15.7 1.0 O A:HOH384 4.9 21.6 1.0 O A:HOH555 4.9 39.1 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Bone Morphogenetic Protein 1 Protease Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Bone Morphogenetic Protein 1 Protease Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn211 b:5.0 occ:0.50 O A:ACE201 2.3 6.0 1.0 O A:HOH221 2.4 9.2 1.0 O A:HOH214 2.4 8.1 1.0 O A:HOH218 2.4 8.2 1.0 NE2 A:GLN189 2.4 5.1 1.0 OE1 A:GLU103 2.5 7.0 1.0 OE2 A:GLU103 2.5 6.5 1.0 CD A:GLU103 2.8 6.2 1.0 C A:ACE201 3.3 6.7 1.0 CD A:GLN189 3.5 8.1 1.0 OE1 A:GLN189 3.8 10.3 1.0 N A:ALA1 3.9 5.7 1.0 O A:HOH216 4.0 7.5 1.0 CB A:ASP142 4.2 7.0 1.0 NH1 A:ARG106 4.2 7.2 1.0 CG A:GLU103 4.4 6.5 1.0 CH3 A:ACE201 4.5 2.8 1.0 O A:HOH231 4.5 12.0 1.0 OG A:SER145 4.7 6.8 1.0 OD1 A:ASP186 4.7 9.8 1.0 CG A:GLN189 4.8 11.6 1.0 OD2 A:ASP142 4.8 7.7 1.0 N A:ASP142 4.8 6.3 1.0 CB A:SER145 4.8 6.4 1.0 O A:THR140 4.9 7.8 1.0 CB A:GLN189 4.9 11.0 1.0 CD A:ARG106 4.9 5.8 1.0 CE2 A:PHE100 5.0 11.0 1.0

A.Mac Sweeney, S.G.Parrado, D.Vinzenz, A.Bernardi, A.Hein, U.Bodendorf, P.Erbel, C.Logel, B.Gerhartz. Structural Basis For the Substrate Specificity of Bone Morphogenetic Protein 1/Tolloid-Like Metalloproteases To Be Published.