Zinc in PDB 3ebg: Structure of the M1 Alanylaminopeptidase From Malaria

The structure of Structure of the M1 Alanylaminopeptidase From Malaria, PDB code: 3ebg was solved by S.Mcgowan, C.J.Porter, A.M.Buckle, J.C.Whisstock, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.60 / 2.10
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	75.656, 108.684, 118.399, 90.00, 90.00, 90.00
R / Rfree (%)	17 / 22

The structure of Structure of the M1 Alanylaminopeptidase From Malaria also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Structure of the M1 Alanylaminopeptidase From Malaria (pdb code 3ebg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of the M1 Alanylaminopeptidase From Malaria, PDB code: 3ebg:

Zinc binding site 1 out of 1 in the Structure of the M1 Alanylaminopeptidase From Malaria


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the M1 Alanylaminopeptidase From Malaria within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:20.7 occ:1.00 O A:HOH1655 1.9 25.2 1.0 NE2 A:HIS500 2.0 15.0 1.0 NE2 A:HIS496 2.1 17.8 1.0 OE1 A:GLU519 2.1 13.8 1.0 O A:HOH86 2.6 19.0 1.0 CD A:GLU519 2.9 15.1 1.0 CD2 A:HIS500 2.9 16.1 1.0 OE2 A:GLU519 3.0 17.3 1.0 CE1 A:HIS500 3.0 16.3 1.0 CD2 A:HIS496 3.0 15.8 1.0 CE1 A:HIS496 3.0 16.9 1.0 MG A:MG1085 3.5 29.5 1.0 O A:HOH1456 3.7 19.1 1.0 OH A:TYR580 4.0 14.2 1.0 CG A:HIS500 4.1 17.4 1.0 ND1 A:HIS500 4.1 15.1 1.0 ND1 A:HIS496 4.1 15.1 1.0 CG A:HIS496 4.2 15.6 1.0 O A:HOH1149 4.2 21.8 1.0 O A:HOH1206 4.3 23.6 1.0 CE1 A:TYR580 4.3 14.9 1.0 CG A:GLU519 4.3 14.9 1.0 OE1 A:GLU497 4.4 19.7 1.0 OE1 A:GLU463 4.5 22.1 1.0 CZ A:TYR580 4.5 13.4 1.0 CG2 A:THR522 4.8 12.4 1.0 OE2 A:GLU497 4.9 21.4 1.0 CA A:GLU519 4.9 15.5 1.0 CB A:THR522 4.9 13.1 1.0 CB A:GLU519 4.9 15.1 1.0 CD A:GLU463 4.9 21.8 1.0 OE2 A:GLU463 5.0 21.7 1.0

S.Mcgowan, C.J.Porter, J.Lowther, C.M.Stack, S.J.Golding, T.S.Skinner-Adams, K.R.Trenholme, F.Teuscher, S.M.Donnelly, J.Grembecka, A.Mucha, P.Kafarski, R.Degori, A.M.Buckle, D.L.Gardiner, J.C.Whisstock, J.P.Dalton. Structural Basis For the Inhibition of the Essential Plasmodium Falciparum M1 Neutral Aminopeptidase Proc.Natl.Acad.Sci.Usa V. 106 2537 2009.
ISSN: ISSN 0027-8424
PubMed: 19196988
DOI: 10.1073/PNAS.0807398106