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Zinc in PDB 3dx2: Golgi Mannosidase II Complex with Mannostatin B

Enzymatic activity of Golgi Mannosidase II Complex with Mannostatin B

All present enzymatic activity of Golgi Mannosidase II Complex with Mannostatin B:
3.2.1.114;

Protein crystallography data

The structure of Golgi Mannosidase II Complex with Mannostatin B, PDB code: 3dx2 was solved by D.A.Kuntz, W.Zhong, J.Guo, D.R.Rose, G.-J.Boons, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.90 / 1.40
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 68.630, 109.281, 137.770, 90.00, 90.00, 90.00
R / Rfree (%) 14.2 / 16.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Golgi Mannosidase II Complex with Mannostatin B (pdb code 3dx2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Mannosidase II Complex with Mannostatin B, PDB code: 3dx2:

Zinc binding site 1 out of 1 in 3dx2

Go back to Zinc Binding Sites List in 3dx2
Zinc binding site 1 out of 1 in the Golgi Mannosidase II Complex with Mannostatin B


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Mannosidase II Complex with Mannostatin B within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1046

b:9.7
occ:1.00
NE2 A:HIS90 2.1 9.2 1.0
OD2 A:ASP204 2.1 10.2 1.0
O4 A:MZB1048 2.1 10.1 1.0
NE2 A:HIS471 2.1 8.8 1.0
O3 A:MZB1048 2.2 9.1 1.0
OD1 A:ASP92 2.2 10.2 1.0
CD2 A:HIS90 3.0 9.3 1.0
CD2 A:HIS471 3.1 10.0 1.0
C4 A:MZB1048 3.1 10.0 1.0
CE1 A:HIS90 3.1 9.2 1.0
C3 A:MZB1048 3.1 10.1 1.0
CG A:ASP204 3.1 9.4 1.0
CG A:ASP92 3.2 9.3 1.0
CE1 A:HIS471 3.2 9.2 1.0
OD2 A:ASP92 3.5 10.4 1.0
CB A:ASP204 3.5 9.3 1.0
N5 A:MZB1048 3.9 10.3 1.0
C5 A:MZB1048 3.9 11.1 1.0
OD2 A:ASP472 4.1 9.7 1.0
CG A:HIS90 4.2 8.4 1.0
ND1 A:HIS90 4.2 8.9 1.0
C1 A:MZB1048 4.2 9.9 1.0
CG A:HIS471 4.3 8.3 1.0
C2 A:MZB1048 4.3 10.0 1.0
ND1 A:HIS471 4.3 8.4 1.0
OD1 A:ASP204 4.3 10.4 1.0
CE1 A:HIS470 4.5 7.8 1.0
CB A:ASP92 4.5 9.8 1.0
O A:HOH1671 4.6 12.2 1.0
OH A:TYR269 4.7 13.8 1.0
O2 A:MZB1048 4.8 10.3 1.0

Reference:

D.A.Kuntz, W.Zhong, J.Guo, D.R.Rose, G.J.Boons. The Molecular Basis of Inhibition of Golgi Alpha-Mannosidase II By Mannostatin A. Chembiochem V. 10 268 2009.
ISSN: ISSN 1439-4227
PubMed: 19101978
DOI: 10.1002/CBIC.200800538
Page generated: Thu Oct 24 12:21:41 2024

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