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Atomistry » Zinc » PDB 3avr-3b6n » 3b3m » |
Zinc in PDB 3b3m: Structure of Neuronal Nos Heme Domain in Complex with A Inhibitor (+-)-3-{Cis-4'-[(6"-Aminopyridin-2"-Yl) Methyl]Pyrrolidin-3'-Ylamino}Propan-1-OlEnzymatic activity of Structure of Neuronal Nos Heme Domain in Complex with A Inhibitor (+-)-3-{Cis-4'-[(6"-Aminopyridin-2"-Yl) Methyl]Pyrrolidin-3'-Ylamino}Propan-1-Ol
All present enzymatic activity of Structure of Neuronal Nos Heme Domain in Complex with A Inhibitor (+-)-3-{Cis-4'-[(6"-Aminopyridin-2"-Yl) Methyl]Pyrrolidin-3'-Ylamino}Propan-1-Ol:
1.14.13.39; Protein crystallography data
The structure of Structure of Neuronal Nos Heme Domain in Complex with A Inhibitor (+-)-3-{Cis-4'-[(6"-Aminopyridin-2"-Yl) Methyl]Pyrrolidin-3'-Ylamino}Propan-1-Ol, PDB code: 3b3m
was solved by
J.Igarashi,
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3b3m:
The structure of Structure of Neuronal Nos Heme Domain in Complex with A Inhibitor (+-)-3-{Cis-4'-[(6"-Aminopyridin-2"-Yl) Methyl]Pyrrolidin-3'-Ylamino}Propan-1-Ol also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Neuronal Nos Heme Domain in Complex with A Inhibitor (+-)-3-{Cis-4'-[(6"-Aminopyridin-2"-Yl) Methyl]Pyrrolidin-3'-Ylamino}Propan-1-Ol
(pdb code 3b3m). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Neuronal Nos Heme Domain in Complex with A Inhibitor (+-)-3-{Cis-4'-[(6"-Aminopyridin-2"-Yl) Methyl]Pyrrolidin-3'-Ylamino}Propan-1-Ol, PDB code: 3b3m: Zinc binding site 1 out of 1 in 3b3mGo back to Zinc Binding Sites List in 3b3m
Zinc binding site 1 out
of 1 in the Structure of Neuronal Nos Heme Domain in Complex with A Inhibitor (+-)-3-{Cis-4'-[(6"-Aminopyridin-2"-Yl) Methyl]Pyrrolidin-3'-Ylamino}Propan-1-Ol
Mono view Stereo pair view
Reference:
H.Ji,
B.Z.Stanton,
J.Igarashi,
H.Li,
P.Martasek,
L.J.Roman,
T.L.Poulos,
R.B.Silverman.
Minimal Pharmacophoric Elements and Fragment Hopping, An Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase Inhibitors. J.Am.Chem.Soc. V. 130 3900 2008.
Page generated: Thu Oct 24 11:24:29 2024
ISSN: ISSN 0002-7863 PubMed: 18321097 DOI: 10.1021/JA0772041 |
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