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Zinc in PDB 2xcm: Complex of HSP90 N-Terminal, SGT1 Cs and RAR1 CHORD2 Domain

Protein crystallography data

The structure of Complex of HSP90 N-Terminal, SGT1 Cs and RAR1 CHORD2 Domain, PDB code: 2xcm was solved by M.Zhang, L.H.Pearl, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.78 / 2.20
Space group P 32
Cell size a, b, c (Å), α, β, γ (°) 88.890, 88.890, 117.820, 90.00, 90.00, 120.00
R / Rfree (%) 19.8 / 24.2

Other elements in 2xcm:

The structure of Complex of HSP90 N-Terminal, SGT1 Cs and RAR1 CHORD2 Domain also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Complex of HSP90 N-Terminal, SGT1 Cs and RAR1 CHORD2 Domain (pdb code 2xcm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Complex of HSP90 N-Terminal, SGT1 Cs and RAR1 CHORD2 Domain, PDB code: 2xcm:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 2xcm

Go back to Zinc Binding Sites List in 2xcm
Zinc binding site 1 out of 4 in the Complex of HSP90 N-Terminal, SGT1 Cs and RAR1 CHORD2 Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Complex of HSP90 N-Terminal, SGT1 Cs and RAR1 CHORD2 Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn1222

b:20.8
occ:1.00
 SG E:CYS178 2.3 21.5 1.0
SG E:CYS159 2.3 20.2 1.0
ND1 E:HIS218 2.3 21.9 1.0
SG E:CYS164 2.4 21.6 1.0
CB E:CYS159 3.1 23.4 1.0
CB E:CYS178 3.1 21.1 1.0
CB E:CYS164 3.2 25.4 1.0
CE1 E:HIS218 3.2 21.4 1.0
CG E:HIS218 3.4 22.1 1.0
CA E:HIS218 3.7 19.2 1.0
CB E:HIS218 3.7 20.6 1.0
CA E:CYS178 4.0 21.0 1.0
ND2 E:ASN161 4.1 22.1 1.0
O E:HOH2016 4.3 25.7 1.0
NE2 E:HIS218 4.4 22.9 1.0
CD2 E:HIS218 4.5 16.0 1.0
CB E:ASN161 4.5 22.3 1.0
N E:HIS218 4.6 24.7 1.0
CA E:CYS159 4.6 24.5 1.0
CA E:CYS164 4.7 28.5 1.0
N E:SER219 4.7 24.6 1.0
CG E:ASN161 4.8 24.9 1.0
C E:HIS218 4.8 24.1 1.0
C E:CYS178 4.8 22.6 1.0

Zinc binding site 2 out of 4 in 2xcm

Go back to Zinc Binding Sites List in 2xcm
Zinc binding site 2 out of 4 in the Complex of HSP90 N-Terminal, SGT1 Cs and RAR1 CHORD2 Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Complex of HSP90 N-Terminal, SGT1 Cs and RAR1 CHORD2 Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn1223

b:22.7
occ:1.00
 ND1 E:HIS181 2.2 19.9 1.0
SG E:CYS196 2.3 21.9 1.0
SG E:CYS197 2.4 22.9 1.0
SG E:CYS213 2.4 24.2 1.0
CE1 E:HIS181 3.0 22.6 1.0
CB E:CYS213 3.2 22.4 1.0
CG E:HIS181 3.3 23.8 1.0
N E:CYS197 3.3 25.3 1.0
CB E:CYS197 3.4 24.4 1.0
CB E:CYS196 3.4 23.0 1.0
CB E:HIS181 3.7 22.6 1.0
CA E:HIS181 3.9 24.2 1.0
CB E:TRP194 3.9 20.4 1.0
CA E:CYS197 4.0 23.8 1.0
C E:CYS196 4.0 27.1 1.0
CA E:CYS196 4.2 24.9 1.0
NE2 E:HIS181 4.2 24.2 1.0
N E:CYS213 4.2 24.2 1.0
CD2 E:HIS181 4.3 22.9 1.0
CA E:CYS213 4.4 23.1 1.0
CD E:PRO182 4.4 19.4 1.0
CG E:TRP194 4.4 22.2 1.0
N E:CYS196 4.5 23.9 1.0
C E:HIS181 4.8 22.0 1.0
N E:PRO182 4.8 20.9 1.0
CD2 E:TRP194 4.9 22.1 1.0

Zinc binding site 3 out of 4 in 2xcm

Go back to Zinc Binding Sites List in 2xcm
Zinc binding site 3 out of 4 in the Complex of HSP90 N-Terminal, SGT1 Cs and RAR1 CHORD2 Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Complex of HSP90 N-Terminal, SGT1 Cs and RAR1 CHORD2 Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Zn1222

b:21.2
occ:1.00
 SG F:CYS178 2.3 22.1 1.0
ND1 F:HIS218 2.3 23.9 1.0
SG F:CYS159 2.3 21.6 1.0
SG F:CYS164 2.4 23.5 1.0
CB F:CYS178 3.1 19.8 1.0
CB F:CYS159 3.1 22.4 1.0
CE1 F:HIS218 3.2 23.0 1.0
CB F:CYS164 3.2 25.6 1.0
CG F:HIS218 3.4 22.8 1.0
CA F:HIS218 3.7 20.4 1.0
CB F:HIS218 3.7 22.4 1.0
CA F:CYS178 4.0 20.3 1.0
ND2 F:ASN161 4.2 18.9 1.0
NE2 F:HIS218 4.3 22.3 1.0
CB F:ASN161 4.4 22.8 1.0
CD2 F:HIS218 4.5 18.1 1.0
O F:HOH2015 4.5 27.3 1.0
N F:HIS218 4.6 24.9 1.0
CA F:CYS159 4.6 25.1 1.0
CA F:CYS164 4.7 29.5 1.0
CG F:ASN161 4.7 25.6 1.0
N F:SER219 4.8 25.8 1.0
C F:HIS218 4.8 25.1 1.0
C F:CYS178 4.9 20.9 1.0

Zinc binding site 4 out of 4 in 2xcm

Go back to Zinc Binding Sites List in 2xcm
Zinc binding site 4 out of 4 in the Complex of HSP90 N-Terminal, SGT1 Cs and RAR1 CHORD2 Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Complex of HSP90 N-Terminal, SGT1 Cs and RAR1 CHORD2 Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Zn1223

b:22.5
occ:1.00
 ND1 F:HIS181 2.2 20.8 1.0
SG F:CYS196 2.4 21.8 1.0
SG F:CYS197 2.4 22.2 1.0
SG F:CYS213 2.4 25.3 1.0
CE1 F:HIS181 3.0 23.6 1.0
CB F:CYS213 3.3 25.9 1.0
N F:CYS197 3.3 24.8 1.0
CG F:HIS181 3.3 24.2 1.0
CB F:CYS197 3.3 23.2 1.0
CB F:CYS196 3.5 23.0 1.0
CB F:HIS181 3.8 23.6 1.0
CB F:TRP194 3.9 18.1 1.0
CA F:HIS181 3.9 24.9 1.0
CA F:CYS197 3.9 24.2 1.0
C F:CYS196 4.0 24.8 1.0
NE2 F:HIS181 4.2 25.1 1.0
CA F:CYS196 4.2 22.1 1.0
N F:CYS213 4.2 27.2 1.0
CD2 F:HIS181 4.4 23.8 1.0
CA F:CYS213 4.4 25.8 1.0
CG F:TRP194 4.4 21.0 1.0
CD F:PRO182 4.5 20.2 1.0
N F:CYS196 4.6 22.4 1.0
C F:HIS181 4.8 23.0 1.0
N F:PRO182 4.9 20.4 1.0
O F:HOH2030 4.9 28.9 1.0
CD2 F:TRP194 4.9 20.3 1.0
O F:CYS196 4.9 25.6 1.0

Reference:

M.Zhang, Y.Kadota, C.Prodromou, K.Shirasu, L.H.Pearl. Structural Basis For Assembly of HSP90-SGT1-Chord Protein Complexes: Implications For Chaperoning of Nlr Innate Immunity Receptors Mol.Cell V. 39 269 2010.
ISSN: ISSN 1097-2765
PubMed: 20670895
DOI: 10.1016/J.MOLCEL.2010.05.010
Page generated: Thu Oct 17 05:16:34 2024

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