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Zinc in PDB 2wm1: The Crystal Structure of Human Alpha-Amino-Beta- Carboxymuconate-Epsilon-Semialdehyde Decarboxylase in Complex with 1,3- Dihydroxyacetonephosphate Suggests A Regulatory Link Between Nad Synthesis and Glycolysis

Enzymatic activity of The Crystal Structure of Human Alpha-Amino-Beta- Carboxymuconate-Epsilon-Semialdehyde Decarboxylase in Complex with 1,3- Dihydroxyacetonephosphate Suggests A Regulatory Link Between Nad Synthesis and Glycolysis

All present enzymatic activity of The Crystal Structure of Human Alpha-Amino-Beta- Carboxymuconate-Epsilon-Semialdehyde Decarboxylase in Complex with 1,3- Dihydroxyacetonephosphate Suggests A Regulatory Link Between Nad Synthesis and Glycolysis:
4.1.1.45;

Protein crystallography data

The structure of The Crystal Structure of Human Alpha-Amino-Beta- Carboxymuconate-Epsilon-Semialdehyde Decarboxylase in Complex with 1,3- Dihydroxyacetonephosphate Suggests A Regulatory Link Between Nad Synthesis and Glycolysis, PDB code: 2wm1 was solved by S.Garavaglia, S.Perozzi, L.Galeazzi, N.Raffaelli, M.Rizzi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.11 / 2.01
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 86.227, 86.227, 92.168, 90.00, 90.00, 120.00
R / Rfree (%) 19.288 / 25.674

Zinc Binding Sites:

The binding sites of Zinc atom in the The Crystal Structure of Human Alpha-Amino-Beta- Carboxymuconate-Epsilon-Semialdehyde Decarboxylase in Complex with 1,3- Dihydroxyacetonephosphate Suggests A Regulatory Link Between Nad Synthesis and Glycolysis (pdb code 2wm1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the The Crystal Structure of Human Alpha-Amino-Beta- Carboxymuconate-Epsilon-Semialdehyde Decarboxylase in Complex with 1,3- Dihydroxyacetonephosphate Suggests A Regulatory Link Between Nad Synthesis and Glycolysis, PDB code: 2wm1:

Zinc binding site 1 out of 1 in 2wm1

Go back to Zinc Binding Sites List in 2wm1
Zinc binding site 1 out of 1 in the The Crystal Structure of Human Alpha-Amino-Beta- Carboxymuconate-Epsilon-Semialdehyde Decarboxylase in Complex with 1,3- Dihydroxyacetonephosphate Suggests A Regulatory Link Between Nad Synthesis and Glycolysis


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Crystal Structure of Human Alpha-Amino-Beta- Carboxymuconate-Epsilon-Semialdehyde Decarboxylase in Complex with 1,3- Dihydroxyacetonephosphate Suggests A Regulatory Link Between Nad Synthesis and Glycolysis within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1333

b:10.3
occ:1.00
NE2 A:HIS6 2.0 7.0 1.0
NE2 A:HIS8 2.1 11.0 1.0
O A:HOH2215 2.1 21.0 1.0
NE2 A:HIS174 2.2 5.5 1.0
OD1 A:ASP291 2.2 13.6 1.0
CE1 A:HIS6 2.8 6.2 1.0
CD2 A:HIS8 2.9 13.2 1.0
CD2 A:HIS174 3.1 4.4 1.0
CD2 A:HIS6 3.1 5.5 1.0
CE1 A:HIS8 3.2 13.4 1.0
CG A:ASP291 3.2 12.9 1.0
CE1 A:HIS174 3.3 4.8 1.0
OD2 A:ASP291 3.7 17.5 1.0
ND1 A:HIS6 4.0 7.5 1.0
O1P A:13P1334 4.1 36.0 1.0
CG A:HIS8 4.1 11.5 1.0
CG A:HIS6 4.2 4.8 1.0
ND1 A:HIS8 4.2 14.1 1.0
CB A:ASP291 4.3 9.4 1.0
O1 A:13P1334 4.3 37.4 1.0
CG A:HIS174 4.3 2.9 1.0
ND1 A:HIS174 4.4 5.9 1.0
O2 A:13P1334 4.4 43.0 1.0
NE2 A:HIS224 4.4 18.2 1.0
CE1 A:HIS224 4.6 13.8 1.0
CA A:ASP291 4.6 9.9 1.0
P A:13P1334 4.9 34.2 1.0

Reference:

S.Garavaglia, S.Perozzi, L.Galeazzi, N.Raffaelli, M.Rizzi. The Crystal Structure of Human Alpha-Amino-Beta- Carboxymuconate-Epsilon-Semialdehyde Decarboxylase in Complex with 1,3-Dihydroxyacetonephosphate Suggests A Regulatory Link Between Nad Synthesis and Glycolysis Febs J. V. 276 6615 2009.
ISSN: ISSN 1742-464X
PubMed: 19843166
DOI: 10.1111/J.1742-4658.2009.07372.X
Page generated: Wed Dec 16 03:58:09 2020

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