Zinc in PDB 2uz9: Human Guanine Deaminase (Guad) in Complex with Zinc and Its Product Xanthine.

All present enzymatic activity of Human Guanine Deaminase (Guad) in Complex with Zinc and Its Product Xanthine.:
3.5.4.3;

The structure of Human Guanine Deaminase (Guad) in Complex with Zinc and Its Product Xanthine., PDB code: 2uz9 was solved by M.Moche, M.Welin, C.Arrowsmith, H.Berglund, R.Busam, R.Collins, L.G.Dahlgren, A.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, B.M.Hallberg, L.Holmberg-Schiavone, I.Johansson, A.Kallas, T.Karlberg, T.Kotenyova, L.Lehtio, T.Nyman, D.Ogg, C.Persson, J.Sagemark, P.Stenmark, M.Sundstrom, A.G.Thorsell, S.Van Den Berg, J.Weigelt, P.Nordlund, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.3
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	91.735, 85.713, 78.960, 90.00, 116.49, 90.00
R / Rfree (%)	16.9 / 22.2

The binding sites of Zinc atom in the Human Guanine Deaminase (Guad) in Complex with Zinc and Its Product Xanthine. (pdb code 2uz9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Guanine Deaminase (Guad) in Complex with Zinc and Its Product Xanthine., PDB code: 2uz9:

Zinc binding site 1 out of 1 in the Human Guanine Deaminase (Guad) in Complex with Zinc and Its Product Xanthine.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Guanine Deaminase (Guad) in Complex with Zinc and Its Product Xanthine. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1452 b:52.5 occ:1.00 NE2 A:HIS82 2.3 19.8 1.0 OD1 A:ASP330 2.3 31.8 1.0 NE2 A:HIS84 2.3 27.1 1.0 NE2 A:HIS240 2.4 26.3 1.0 C2 A:XAN1453 2.9 56.4 1.0 O2 A:XAN1453 3.0 56.2 1.0 CD2 A:HIS84 3.0 26.8 1.0 CD2 A:HIS240 3.0 26.5 1.0 CD2 A:HIS82 3.1 19.9 1.0 N1 A:XAN1453 3.1 56.1 1.0 CG A:ASP330 3.2 24.5 1.0 CE1 A:HIS82 3.3 21.1 1.0 CE1 A:HIS84 3.4 27.5 1.0 OD2 A:ASP330 3.5 27.6 1.0 CE1 A:HIS240 3.6 29.6 1.0 N3 A:XAN1453 3.6 56.0 1.0 O A:HOH2031 3.8 15.0 1.0 C6 A:XAN1453 3.8 55.4 1.0 NE2 A:HIS279 3.8 24.2 1.0 C4 A:XAN1453 4.2 55.0 1.0 CG A:HIS84 4.3 26.3 1.0 CG A:HIS82 4.3 22.6 1.0 CG A:HIS240 4.3 26.5 1.0 C5 A:XAN1453 4.4 55.4 1.0 CB A:ASP330 4.4 25.2 1.0 ND1 A:HIS82 4.4 21.1 1.0 ND1 A:HIS84 4.4 27.3 1.0 ND1 A:HIS240 4.5 28.2 1.0 O6 A:XAN1453 4.5 55.4 1.0 CE1 A:HIS279 4.6 25.8 1.0 CB A:ALA278 4.7 21.6 1.0 CD2 A:HIS279 4.7 22.3 1.0 CA A:ASP330 4.9 25.0 1.0

M.Moche, M.Welin, C.Arrowsmith, H.Berglund, R.Busam, R.Collins, L.G.Dahlgren, A.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, B.M.Hallberg, L.Holmberg-Schiavone, I.Johansson, A.Kallas, T.Karlberg, T.Kotenyova, L.Lehtio, T.Nyman, D.Ogg, C.Persson, J.Sagemark, P.Stenmark, M.Sundstrom, A.G.Thorsell, S.Van Den Berg, J.Weigelt, P.Nordlund. Human Guanine Deaminase (Guad) in Complex with Zinc and Its Product Xhantine To Be Published.