Zinc in PDB 2rku: Structure of PLK1 in Complex with BI2536

All present enzymatic activity of Structure of PLK1 in Complex with BI2536:
2.7.11.21;

The structure of Structure of PLK1 in Complex with BI2536, PDB code: 2rku was solved by Y.-H.Ding, M.Kothe, D.Kohls, S.Low, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.41 / 1.95
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	66.593, 66.593, 154.110, 90.00, 90.00, 120.00
R / Rfree (%)	19 / 24.1

The binding sites of Zinc atom in the Structure of PLK1 in Complex with BI2536 (pdb code 2rku). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of PLK1 in Complex with BI2536, PDB code: 2rku:

Zinc binding site 1 out of 1 in the Structure of PLK1 in Complex with BI2536


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of PLK1 in Complex with BI2536 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:34.3 occ:1.00 O1 A:TLA502 2.0 35.6 1.0 NE2 A:HIS93 2.1 41.4 1.0 SG A:CYS212 2.3 44.7 1.0 C1 A:TLA502 2.9 38.0 1.0 CD2 A:HIS93 3.0 43.0 1.0 CE1 A:HIS93 3.1 44.0 1.0 O11 A:TLA502 3.1 40.5 1.0 CB A:CYS212 3.2 47.3 1.0 NZ A:LYS97 3.9 48.2 1.0 ND1 A:HIS93 4.2 44.6 1.0 CG A:HIS93 4.2 42.2 1.0 C2 A:TLA502 4.3 39.5 1.0 O A:HOH746 4.4 47.1 1.0 CA A:CYS212 4.5 47.4 1.0 CE A:LYS97 4.6 46.5 1.0 O A:HOH680 4.7 60.9 1.0 CD A:LYS97 4.8 45.6 1.0 O A:HOH637 4.8 43.0 1.0 C3 A:TLA502 4.8 40.1 1.0 O3 A:TLA502 5.0 38.6 1.0

M.Kothe, D.Kohls, S.Low, R.Coli, G.R.Rennie, F.Feru, C.Kuhn, Y.-H.Ding. Selectivity-Determining Residues in PLK1. Chem.Biol.Drug Des. V. 70 540 2007.
ISSN: ISSN 1747-0277
PubMed: 18005335
DOI: 10.1111/J.1747-0285.2007.00594.X