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Zinc in PDB 2riq: Crystal Structure of the Third Zinc-Binding Domain of Human Parp-1

Enzymatic activity of Crystal Structure of the Third Zinc-Binding Domain of Human Parp-1

All present enzymatic activity of Crystal Structure of the Third Zinc-Binding Domain of Human Parp-1:
2.4.2.30;

Protein crystallography data

The structure of Crystal Structure of the Third Zinc-Binding Domain of Human Parp-1, PDB code: 2riq was solved by J.M.Pascal, M.F.Langelier, K.M.Servent, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.70
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 71.841, 85.652, 67.758, 90.00, 90.00, 90.00
R / Rfree (%) 17.8 / 23

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Third Zinc-Binding Domain of Human Parp-1 (pdb code 2riq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Third Zinc-Binding Domain of Human Parp-1, PDB code: 2riq:

Zinc binding site 1 out of 1 in 2riq

Go back to Zinc Binding Sites List in 2riq
Zinc binding site 1 out of 1 in the Crystal Structure of the Third Zinc-Binding Domain of Human Parp-1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Third Zinc-Binding Domain of Human Parp-1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1

b:35.6
occ:1.00
SG A:CYS321 2.3 35.5 1.0
SG A:CYS311 2.3 35.0 1.0
SG A:CYS295 2.3 37.1 1.0
SG A:CYS298 2.4 35.6 1.0
CB A:CYS321 3.0 36.0 1.0
CB A:CYS295 3.0 37.7 1.0
CB A:CYS311 3.2 34.7 1.0
CB A:CYS298 3.4 37.4 1.0
N A:CYS298 3.9 38.5 1.0
CA A:CYS298 4.1 37.6 1.0
CG2 A:VAL323 4.2 36.3 1.0
CB A:VAL323 4.2 35.0 1.0
N A:GLY300 4.5 37.2 1.0
CA A:CYS321 4.5 35.3 1.0
CA A:CYS295 4.5 37.8 1.0
C A:CYS298 4.6 37.9 1.0
CA A:CYS311 4.6 33.9 1.0
N A:SER299 4.7 37.5 1.0
N A:GLY313 4.7 35.4 1.0
C A:GLU297 4.8 39.3 1.0
CB A:GLU297 4.8 39.6 1.0
O A:HOH425 4.8 46.2 1.0
CA A:GLY313 4.8 35.6 1.0
CA A:GLY300 4.8 35.8 1.0
CG1 A:VAL323 5.0 37.3 1.0

Reference:

M.F.Langelier, K.M.Servent, E.E.Rogers, J.M.Pascal. A Third Zinc-Binding Domain of Human Poly(Adp-Ribose) Polymerase-1 Coordinates Dna-Dependent Enzyme Activation. J.Biol.Chem. V. 283 4105 2008.
ISSN: ISSN 0021-9258
PubMed: 18055453
DOI: 10.1074/JBC.M708558200
Page generated: Wed Dec 16 03:52:17 2020

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