Atomistry » Zinc » PDB 2rgm-2rv2 » 2rhk
Atomistry »
  Zinc »
    PDB 2rgm-2rv2 »
      2rhk »

Zinc in PDB 2rhk: Crystal Structure of Influenza A NS1A Protein in Complex with F2F3 Fragment of Human Cellular Factor CPSF30, Northeast Structural Genomics Targets OR8C and HR6309A

Protein crystallography data

The structure of Crystal Structure of Influenza A NS1A Protein in Complex with F2F3 Fragment of Human Cellular Factor CPSF30, Northeast Structural Genomics Targets OR8C and HR6309A, PDB code: 2rhk was solved by K.Das, L.-C.Ma, R.Xiao, B.Radvansky, J.Aramini, L.Zhao, E.Arnold, R.M.Krug, G.T.Montelione, Northeast Structural Genomicsconsortium (Nesg), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 1.95
Space group P 41
Cell size a, b, c (Å), α, β, γ (°) 50.960, 50.960, 205.390, 90.00, 90.00, 90.00
R / Rfree (%) 21 / 23.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Influenza A NS1A Protein in Complex with F2F3 Fragment of Human Cellular Factor CPSF30, Northeast Structural Genomics Targets OR8C and HR6309A (pdb code 2rhk). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Influenza A NS1A Protein in Complex with F2F3 Fragment of Human Cellular Factor CPSF30, Northeast Structural Genomics Targets OR8C and HR6309A, PDB code: 2rhk:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 2rhk

Go back to Zinc Binding Sites List in 2rhk
Zinc binding site 1 out of 4 in the Crystal Structure of Influenza A NS1A Protein in Complex with F2F3 Fragment of Human Cellular Factor CPSF30, Northeast Structural Genomics Targets OR8C and HR6309A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Influenza A NS1A Protein in Complex with F2F3 Fragment of Human Cellular Factor CPSF30, Northeast Structural Genomics Targets OR8C and HR6309A within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn502

b:30.3
occ:1.00
NE2 C:HIS114 2.2 22.2 1.0
SG C:CYS110 2.3 30.5 1.0
SG C:CYS96 2.3 29.1 1.0
SG C:CYS105 2.4 25.6 1.0
CD2 C:HIS114 3.0 27.0 1.0
CB C:CYS110 3.1 26.5 1.0
CB C:CYS105 3.1 26.9 1.0
CE1 C:HIS114 3.2 30.6 1.0
CB C:CYS96 3.2 25.9 1.0
CG C:HIS114 4.2 31.2 1.0
ND1 C:HIS114 4.3 32.2 1.0
O C:HOH504 4.4 34.7 1.0
O C:PHE112 4.5 33.0 1.0
CA C:CYS110 4.6 28.6 1.0
CA C:CYS105 4.6 27.6 1.0
CA C:CYS96 4.6 29.3 1.0
CB C:TYR99 4.6 29.1 1.0
NE2 A:GLN121 4.8 30.1 1.0
CB C:PHE112 4.8 30.0 1.0
O C:HOH515 4.8 38.3 1.0
N C:TYR99 4.9 28.8 1.0
O A:HOH229 4.9 41.8 1.0

Zinc binding site 2 out of 4 in 2rhk

Go back to Zinc Binding Sites List in 2rhk
Zinc binding site 2 out of 4 in the Crystal Structure of Influenza A NS1A Protein in Complex with F2F3 Fragment of Human Cellular Factor CPSF30, Northeast Structural Genomics Targets OR8C and HR6309A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Influenza A NS1A Protein in Complex with F2F3 Fragment of Human Cellular Factor CPSF30, Northeast Structural Genomics Targets OR8C and HR6309A within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn501

b:42.8
occ:1.00
NE2 C:HIS86 2.2 33.5 1.0
SG C:CYS76 2.4 44.2 1.0
SG C:CYS82 2.4 41.1 1.0
SG C:CYS68 2.4 36.5 1.0
CE1 C:HIS86 3.1 34.8 1.0
CB C:CYS82 3.1 38.8 1.0
CD2 C:HIS86 3.2 35.1 1.0
CB C:CYS68 3.3 31.9 1.0
CB C:CYS76 3.3 50.4 1.0
CB C:TRP71 4.2 38.1 1.0
ND1 C:HIS86 4.2 39.2 1.0
CG C:HIS86 4.3 36.1 1.0
CA C:CYS82 4.6 40.8 1.0
O C:PHE84 4.7 33.8 1.0
CB C:LYS78 4.7 45.4 1.0
N C:TRP71 4.7 41.9 1.0
CA C:CYS68 4.7 33.5 1.0
CA C:CYS76 4.7 51.4 1.0
CD C:LYS78 4.9 53.6 1.0
CA C:TRP71 4.9 40.1 1.0
CB C:PHE84 4.9 38.0 1.0

Zinc binding site 3 out of 4 in 2rhk

Go back to Zinc Binding Sites List in 2rhk
Zinc binding site 3 out of 4 in the Crystal Structure of Influenza A NS1A Protein in Complex with F2F3 Fragment of Human Cellular Factor CPSF30, Northeast Structural Genomics Targets OR8C and HR6309A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Influenza A NS1A Protein in Complex with F2F3 Fragment of Human Cellular Factor CPSF30, Northeast Structural Genomics Targets OR8C and HR6309A within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn502

b:29.1
occ:1.00
NE2 D:HIS114 2.1 23.6 1.0
SG D:CYS96 2.3 29.2 1.0
SG D:CYS110 2.4 29.2 1.0
SG D:CYS105 2.4 29.6 1.0
CD2 D:HIS114 3.0 30.2 1.0
CB D:CYS96 3.1 28.4 1.0
CB D:CYS110 3.1 24.2 1.0
CB D:CYS105 3.2 30.2 1.0
CE1 D:HIS114 3.2 31.4 1.0
CG D:HIS114 4.2 28.1 1.0
ND1 D:HIS114 4.3 27.2 1.0
O D:HOH505 4.5 37.9 1.0
CA D:CYS96 4.5 30.6 1.0
CB D:TYR99 4.6 34.5 1.0
CA D:CYS110 4.6 24.9 1.0
O D:PHE112 4.6 32.5 1.0
CA D:CYS105 4.6 31.0 1.0
NE2 B:GLN121 4.8 29.7 1.0
CB D:PHE112 4.8 26.6 1.0
O D:HOH506 4.9 36.1 1.0
N D:TYR99 4.9 33.1 1.0

Zinc binding site 4 out of 4 in 2rhk

Go back to Zinc Binding Sites List in 2rhk
Zinc binding site 4 out of 4 in the Crystal Structure of Influenza A NS1A Protein in Complex with F2F3 Fragment of Human Cellular Factor CPSF30, Northeast Structural Genomics Targets OR8C and HR6309A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Influenza A NS1A Protein in Complex with F2F3 Fragment of Human Cellular Factor CPSF30, Northeast Structural Genomics Targets OR8C and HR6309A within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn501

b:44.4
occ:1.00
NE2 D:HIS86 2.2 29.4 1.0
SG D:CYS76 2.3 42.6 1.0
SG D:CYS82 2.4 43.9 1.0
SG D:CYS68 2.5 35.8 1.0
CD2 D:HIS86 3.1 29.8 1.0
CB D:CYS82 3.1 45.1 1.0
CE1 D:HIS86 3.2 31.5 1.0
CB D:CYS68 3.2 29.7 1.0
CB D:CYS76 3.3 52.6 1.0
CB D:TRP71 4.2 32.4 1.0
CG D:HIS86 4.3 32.6 1.0
ND1 D:HIS86 4.3 31.6 1.0
CA D:CYS82 4.6 47.4 1.0
O D:PHE84 4.6 30.8 1.0
CA D:CYS68 4.7 31.3 1.0
N D:TRP71 4.7 35.3 1.0
CA D:CYS76 4.8 52.1 1.0
CB D:PHE84 4.8 36.9 1.0
CA D:TRP71 4.9 32.9 1.0
CB D:LYS78 5.0 53.8 1.0

Reference:

K.Das, L.C.Ma, R.Xiao, B.Radvansky, J.Aramini, L.Zhao, J.Marklund, R.L.Kuo, K.Y.Twu, E.Arnold, R.M.Krug, G.T.Montelione. Structural Basis For Suppression of A Host Antiviral Response By Influenza A Virus. Proc.Natl.Acad.Sci.Usa V. 105 13093 2008.
ISSN: ISSN 0027-8424
PubMed: 18725644
DOI: 10.1073/PNAS.0805213105
Page generated: Wed Dec 16 03:52:12 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy