Zinc in PDB 2qym: Crystal Structure of Unliganded PDE4C2

The structure of Crystal Structure of Unliganded PDE4C2, PDB code: 2qym was solved by H.Ke, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 1.90
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	74.738, 74.738, 275.910, 90.00, 90.00, 120.00
R / Rfree (%)	20.8 / 22.9

The structure of Crystal Structure of Unliganded PDE4C2 also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Zinc atom in the Crystal Structure of Unliganded PDE4C2 (pdb code 2qym). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Unliganded PDE4C2, PDB code: 2qym:

Zinc binding site 1 out of 1 in the Crystal Structure of Unliganded PDE4C2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Unliganded PDE4C2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:25.2 occ:1.00 OD2 A:ASP323 2.1 20.9 1.0 OD1 A:ASP440 2.1 21.2 1.0 O A:HOH558 2.1 20.9 1.0 NE2 A:HIS322 2.1 20.2 1.0 NE2 A:HIS286 2.1 20.5 1.0 O A:HOH559 2.3 21.9 1.0 CD2 A:HIS322 3.0 19.8 1.0 CG A:ASP440 3.0 22.3 1.0 CD2 A:HIS286 3.1 20.9 1.0 CG A:ASP323 3.1 20.8 1.0 CE1 A:HIS286 3.1 20.1 1.0 CE1 A:HIS322 3.2 20.0 1.0 OD2 A:ASP440 3.4 23.8 1.0 OD1 A:ASP323 3.6 21.5 1.0 MG A:MG2 3.7 24.3 1.0 O A:HOH560 4.1 17.7 1.0 CD2 A:HIS282 4.1 20.9 1.0 CG A:HIS322 4.2 20.2 1.0 O A:HOH573 4.2 23.1 1.0 ND1 A:HIS322 4.2 19.0 1.0 ND1 A:HIS286 4.2 19.8 1.0 CG A:HIS286 4.2 21.1 1.0 NE2 A:HIS282 4.3 20.8 1.0 CB A:ASP323 4.3 20.3 1.0 CB A:ASP440 4.3 21.5 1.0 CG2 A:VAL290 4.7 19.8 1.0 O A:HOH563 4.7 18.9 1.0 CA A:ASP440 5.0 21.1 1.0

H.Wang, M.S.Peng, Y.Chen, J.Geng, H.Robinson, M.D.Houslay, J.Cai, H.Ke. Structures of the Four Subfamilies of Phosphodiesterase-4 Provide Insight Into the Selectivity of Their Inhibitors. Biochem.J. V. 408 193 2007.
ISSN: ISSN 0264-6021
PubMed: 17727341
DOI: 10.1042/BJ20070970