Zinc in PDB 2ql1: Structural Characterization of A Mutated, Adcc-Enhanced Human Fc Fragment

The structure of Structural Characterization of A Mutated, Adcc-Enhanced Human Fc Fragment, PDB code: 2ql1 was solved by V.Oganesyan, H.Wu, W.F.Dall'acqua, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.25 / 2.53
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	49.869, 147.492, 74.315, 90.00, 90.00, 90.00
R / Rfree (%)	23.2 / 29.3

The binding sites of Zinc atom in the Structural Characterization of A Mutated, Adcc-Enhanced Human Fc Fragment (pdb code 2ql1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structural Characterization of A Mutated, Adcc-Enhanced Human Fc Fragment, PDB code: 2ql1:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structural Characterization of A Mutated, Adcc-Enhanced Human Fc Fragment


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Characterization of A Mutated, Adcc-Enhanced Human Fc Fragment within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:52.5 occ:1.00 NE2 A:HIS310 1.9 22.8 1.0 NE2 A:HIS435 2.0 30.9 1.0 O A:HOH451 2.5 38.4 1.0 O A:HOH458 2.6 48.5 1.0 CE1 A:HIS310 2.8 23.2 1.0 CD2 A:HIS310 2.9 22.0 1.0 CD2 A:HIS435 3.0 29.6 1.0 CE1 A:HIS435 3.0 27.8 1.0 CD1 A:LEU314 3.7 35.0 1.0 ND1 A:HIS310 4.0 22.1 1.0 CG A:HIS310 4.0 25.8 1.0 ND1 A:HIS435 4.1 25.9 1.0 CG A:HIS435 4.1 26.7 1.0

Zinc binding site 2 out of 4 in the Structural Characterization of A Mutated, Adcc-Enhanced Human Fc Fragment


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structural Characterization of A Mutated, Adcc-Enhanced Human Fc Fragment within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2 b:83.1 occ:0.50 NE2 A:HIS433 2.3 25.6 1.0 CE1 A:HIS433 2.8 23.0 1.0 CD2 A:HIS433 3.5 24.9 1.0 ND1 A:HIS433 4.1 21.2 1.0 ND2 A:ASN434 4.2 23.3 1.0 CG A:HIS433 4.4 23.2 1.0 CG A:ASN434 4.9 23.4 1.0 OD1 A:ASN434 4.9 22.6 1.0

Zinc binding site 3 out of 4 in the Structural Characterization of A Mutated, Adcc-Enhanced Human Fc Fragment


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structural Characterization of A Mutated, Adcc-Enhanced Human Fc Fragment within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn3 b:61.2 occ:0.50 O A:HOH465 1.9 53.3 1.0 OE2 A:GLU318 2.3 42.6 1.0 OE1 A:GLU318 2.7 40.2 1.0 CD A:GLU318 2.8 39.0 1.0 CG A:GLU318 4.2 37.1 1.0 CG2 A:THR335 4.3 41.7 1.0 CB A:GLU318 4.9 36.1 1.0 CB A:THR335 4.9 41.5 1.0

Zinc binding site 4 out of 4 in the Structural Characterization of A Mutated, Adcc-Enhanced Human Fc Fragment


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structural Characterization of A Mutated, Adcc-Enhanced Human Fc Fragment within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn4 b:0.1 occ:1.00 OE1 A:GLU345 2.3 38.1 1.0 CD A:GLU345 2.8 35.9 1.0 OE2 A:GLU345 2.8 41.8 1.0 O A:HOH453 2.8 64.6 1.0 N A:HIS433 3.9 24.8 1.0 CG A:GLU345 4.1 33.9 1.0 CB A:HIS433 4.2 22.8 1.0 CA A:HIS433 4.6 23.9 1.0 O A:ALA431 4.6 27.6 1.0 CA A:LEU432 4.7 24.1 1.0 C A:LEU432 4.7 24.3 1.0 CD2 A:LEU432 5.0 17.4 1.0

V.Oganesyan, M.M.Damschroder, W.Leach, H.Wu, W.F.Dall'acqua. Structural Characterization of A Mutated, Adcc-Enhanced Human Fc Fragment Mol.Immunol. V. 45 1872 2008.
ISSN: ISSN 0161-5890
PubMed: 18078997
DOI: 10.1016/J.MOLIMM.2007.10.042