Zinc in PDB 2ouy: Crystal Structure of PDE10A2 Mutant D564A in Complex with Camp.

All present enzymatic activity of Crystal Structure of PDE10A2 Mutant D564A in Complex with Camp.:
3.1.4.17;

The structure of Crystal Structure of PDE10A2 Mutant D564A in Complex with Camp., PDB code: 2ouy was solved by H.C.Wang, Y.D.Liu, J.Hou, M.Y.Zheng, H.Robinson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 1.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	49.391, 82.266, 155.931, 90.00, 90.00, 90.00
R / Rfree (%)	21.7 / 25.3

The structure of Crystal Structure of PDE10A2 Mutant D564A in Complex with Camp. also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Crystal Structure of PDE10A2 Mutant D564A in Complex with Camp. (pdb code 2ouy). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of PDE10A2 Mutant D564A in Complex with Camp., PDB code: 2ouy:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of PDE10A2 Mutant D564A in Complex with Camp.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of PDE10A2 Mutant D564A in Complex with Camp. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn777 b:33.1 occ:1.00 OD1 A:ASP674 2.1 23.9 1.0 OD1 A:ASN564 2.1 27.4 1.0 NE2 A:HIS529 2.1 23.8 1.0 NE2 A:HIS563 2.1 26.3 1.0 O A:HOH2 2.4 29.0 1.0 O A:HOH1 2.4 24.2 1.0 CD2 A:HIS563 2.8 24.6 1.0 CD2 A:HIS529 2.9 21.3 1.0 CG A:ASP674 3.1 20.7 1.0 CE1 A:HIS529 3.2 21.6 1.0 CE1 A:HIS563 3.3 25.1 1.0 CG A:ASN564 3.3 25.2 1.0 OD2 A:ASP674 3.5 21.4 1.0 ND2 A:ASN564 4.0 25.7 1.0 CG A:HIS563 4.0 24.0 1.0 MG A:MG778 4.1 28.2 1.0 CG A:HIS529 4.2 20.5 1.0 ND1 A:HIS563 4.2 24.6 1.0 O A:HOH69 4.2 19.3 1.0 ND1 A:HIS529 4.2 20.9 1.0 CD2 A:HIS525 4.3 19.2 1.0 CB A:ASP674 4.4 19.0 1.0 CB A:ASN564 4.4 24.3 1.0 CG2 A:VAL533 4.5 13.7 1.0 O2P A:CMP779 4.6 43.0 1.0 CA A:ASP674 4.7 17.3 1.0 O A:HOH5 4.8 27.9 1.0 O A:ASP674 4.8 17.2 1.0 NE2 A:HIS525 4.9 19.8 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of PDE10A2 Mutant D564A in Complex with Camp.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of PDE10A2 Mutant D564A in Complex with Camp. within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn777 b:34.8 occ:1.00 OD1 B:ASP674 2.1 26.9 1.0 OD1 B:ASN564 2.1 32.7 1.0 NE2 B:HIS563 2.1 29.4 1.0 NE2 B:HIS529 2.1 26.9 1.0 O B:HOH11 2.3 30.0 1.0 O B:HOH12 2.7 45.5 1.0 CD2 B:HIS529 2.8 24.7 1.0 CD2 B:HIS563 2.9 28.2 1.0 CG B:ASN564 3.2 31.3 1.0 CE1 B:HIS563 3.2 28.5 1.0 CG B:ASP674 3.3 23.7 1.0 CE1 B:HIS529 3.3 24.9 1.0 ND2 B:ASN564 3.8 32.0 1.0 OD2 B:ASP674 3.9 25.1 1.0 O B:HOH13 4.0 43.9 1.0 CG B:HIS529 4.1 23.8 1.0 CG B:HIS563 4.1 27.9 1.0 ND1 B:HIS563 4.2 28.1 1.0 MG B:MG778 4.2 34.1 1.0 ND1 B:HIS529 4.3 24.4 1.0 CB B:ASP674 4.4 21.9 1.0 CB B:ASN564 4.5 30.5 1.0 CG2 B:VAL533 4.6 16.3 1.0 CA B:ASP674 5.0 19.7 1.0

H.Wang, Y.Liu, J.Hou, M.Zheng, H.Robinson, H.Ke. From the Cover: Structural Insight Into Substrate Specificity of Phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa V. 104 5782 2007.
ISSN: ISSN 0027-8424
PubMed: 17389385
DOI: 10.1073/PNAS.0700279104